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Dr. Dipak Datta |
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Scientist E-I
Drug Target Discovery & Development
Central Drug Research Institute - CSIR
Chattar Manzil Palace, Post Box No. 173
Lucknow - 226001, India
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| Educational qualifications |
M.Sc. (1997) University of Burdwan, West Bengal.
Ph.D. (2004) CNCI/Jadavpur University, Kolkata, West Bengal |
| Date of Birth |
03.12.1973 |
| E mail |
dipak.datta@cdri.res.in |
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| POSITIONS / EMPLOYMENT |
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2004 -2010 |
Postdoctoral Fellow, Division of Nephrology, Children’s Hospital Boston, Harvard Medical School, Boston, MA |
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2010- 2011 |
Instructor in Pathology, Harvard Medical School, Department of Pathology, BIDMC, Boston, MA. |
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HONORS/AWARDS |
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1sT Class 1st Award in B.Sc - University of Burdwan |
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Young Investigator Award 2007 – American Transplant Society |
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Young Investigator Award 2010 – American Transplant Society |
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| CURRENT AREAS OF INTEREST |
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.Chemokine Receptor Signaling |
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MicroRNA and Cancer |
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PI3K-mTOR network in Cancer |
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| SELECTED
PUBLICATIONS
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Hoerning A, Koss K, Datta D, Boneschanker L, Jones CN, Wong IY, Irimia D, Calzadilla K, Benitez F, Hoyer PF, Harmon WE, and Briscoe DM. Subsets of human CD4(+) regulatory T cells express peripheral homing receptor CXCR3. 2011 Eur J Immunol (in-press; PMID: 21538345) |
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Datta D, Banerjee P, Gasser M, Waaga-Gasser AM, and Pal S. CXCR3-B can mediate growth-inhibitory signals in human renal cancer cells by downregulating the expression of heme oxygenase-1. 2010 J Biol Chem (285;47: 36842-8) |
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Basu A, Datta D, Zurakowski D, and Pal S. Altered vascular endothelial growth factor mRNA stability following treatments with immunosuppressive agents: implications for cancer development.
2010 J Biol Chem (285;33: 25196-202) |
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Edelbauer M, Datta D, Vos I, Basu A, Stack P, Reinders M, Sho M, Calzadilla K, Ganz P, and Briscoe D. M. Effect of vascular endothelial growth factor and its receptor KDR on the trans-endothelial migration and local trafficking of human T cells in vitro and in vivo. 2010 Blood. (116;11: 1980-9) |
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Basu A*, Hoerning A*, Datta D, Edelbauer M, Stack MP, Calzadilla K, Pal S, and Briscoe D. M. Vascular endothelial growth factor mediated signaling in human memory T cells promotes AKT and ERK activation and co-stimulates IFNg production. 2010 J Immunol. (Cutting Edge). (184;2: 545-9) (* Equal Contribution) |
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Datta D, Contrearas AG, Basu A, Dormond O, Flynn E, Briscoe DM, and Pal S. Calcineurin inhibitors activate the proto-oncogene Ras and promote protumorigenic signals in renal cancer cells. 2009. Cancer Res. (69; 23: 8902-9). |
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Dormond O, Contreras AG, Meijer E, Datta D, Flynn E, Pal S, and Briscoe DM. Ligation of CD40 on human endothelial cells results in mTOR dependent activation of Akt in-vitro and angiogenesis in-vivo. 2008, J Immunol. (181;11: 8088-95) |
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Datta D, Contreras AG, Grimm M, Waaga Gasser AM, Briscoe DM, and Pal S. Calcineurin inhibitors modulate CXCR3 splice variant expression and mediate renal cancer progression. 2008, J Am Soc Nephrol. (19; 12: 2437-46; Impact Factor - 7.79). |
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Basu A*, Contreras AG*, Datta D, Flynn E, Zeng L, Cohen H, Briscoe DM, and Pal S. Overexpression of vascular endothelial growth factor and the development of post-transplantation cancer. 2008. Cancer Res. (68; 14: 5689-98). (* Equal Contribution). |
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Datta D., Dormond O., Basu A., Briscoe DM., and Pal S. Heme Oxygenase-1 (HO-1) modulates the expression of the anti-angiogenic chemokine CXCL10 in renal tubular epithelial cells. 2007 Am J Physiol. Renal Physiol. (293; 4:F1222-30) |
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Datta D., Flaxenburg J. A., Laxmanan S., Geehan C., Grimm M., Waaga-Gasser AM., Briscoe D. M. and Pal S. Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: Relevance for the development of human breast cancer. 2006 Cancer Res. (66; 19: 9509-18) |
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Laxmanan S., Datta D., Geehan C., Briscoe D. M. and Pal S. CD40: A mediator of pro- and anti-inflammatory signals in renal tubular epithelial cells. 2005. J Am Soc Nephrol. (16; 9: 2714-23) |
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