Biodata of Dr Mrigank Srivastava :::: Central Drug Research Institute

Dr. MRIGANK SRIVASTAVA

Scientist C
Parasitology Division
Central Drug Research Institute
Lucknow 226 001.

E- mail	mrigank_srivastava@cdri.res.in
Tel	0522-2612411-18 (Ext. 4405)
Educational Qualifications	M.Sc. (HP University, Shimla) Ph.D. (Justus-Liebig University, Giessen, Germany)
Date of Birth	2nd December, 1977

POST DOCTORAL EXPERIENCE

•	Hannover Medical School, Hannover, Germany(Jan 2005-Feb 2008)
•	Dana Farber Cancer Institute, Harvard Medical School, Boston, USA(March 2008-Nov 2010)

AREAS OF INTEREST

•	Immunology (Acute and Chronic inflammatory reactions in the lungs)
•	Infection Biology (Lung Infections - Mycobacterial, Pneumococcal and Pulmonary Fibrosis)
•	Transplantation Immunology (GVHD)
•	Filariasis

SELECTED PUBLICATIONS

•	Herbold W, Maus R, Srivastava M, Mack M, Winter C, Briles DE, Paton JC, Welte T, Maus UA. Important role of CXC chemokine receptor 2 (CXCR2) in neutrophil and exudate macrophage dependent lung protective immunity against S. pneumoniae. Infect Immun. 78(6):2620-30, 2010.
•	Schreiber O, Steinwede K, Ding N, Srivastava M, Maus R, Länger F, Prokein J, Ehlers S, Welte T, Gunn MD, Maus UA. Mice that overexpress CC chemokine ligand 2 in their lungs show increased protective immunity to infection with Mycobacterium bovis bacille Calmette-Guérin. J Infect Dis. 198:1044–1054, 2008.
•	Srivastava M, Steinwede K, Kiviranta R, Morko J, Hoymann HG, Langer F, Buhling F, Welte T, Maus UA. Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis. Respir Res. 9:54, 2008.
•	Winter C, Taut K, Länger F, Mack M, Briles DE, Paton JC, Maus R, Srivastava M, Welte T, Maus UA. FMS-like tyrosine kinase 3 ligand aggravates the lung inflammatory response to S. Pneumoniae infection in mice: Role of dendritic cells. J Immunol.179:3099-4108, 2007.
•	Winter C, Taut K, Srivastava M, Länger F, Mack M, Briles DE, Paton JC, Maus R, Welte T, Gunn MD, Maus UA. Lung specific overexpression of CC chemokine ligand (CCL) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: Role of CCL2-CCR2 axis. J Immunol. 178: 5828-5838, 2007.
•	Maus UA, Backi M, Winter C, Srivastava M, Schwarz MK, Ruckle T, Paton JC, Briles D, Mack M, Welte T, Maus R, Bohle RM, Seeger W, Rommel C, Hirsch E, Lohmeyer J, Preissner KT. Importance of Phosphoinositide 3-Kinase ? in the host defense against Pneumococcal infection. Am J Respir Crit Care Med. 175:958-66, 2007.
•	Srivastava M, Meinders A, Steinwede K, Maus R, Lucke N, Bühling F, Ehlers S, Welte T, Maus UA. Mediator responses of alveolar macrophages and kinetics of mononuclear phagocyte subset recruitment during acute primary and secondary mycobacterial infections in the lungs of mice. Cell Microbiol. 9: 738-52, 2007.
•	Herold S, Wulffen W v, Steinmueller M, Pleschka S, Kuziel WA, Mack M, Srivastava M, Seeger W, Maus.UA, Lohmeyer J. Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: Impact of chemokines and adhesion molecules. J Immunol. 177: 1817-1824, 2006.
•	Maus.UA, Janzen S, Wall G, Srivastava M, Blackwell TS, Christman JW, Seeger W, Welte T, Lohmeyer J. Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation. Am J Respir Cell Mol Biol. 35: 227-235, 2006.
•	Steinmueller M, Srivastava M, Kuziel WA, Christman JW, Seeger W, Welte T, Lohmeyer J, Maus UA. Endotoxin induced peritonitis elicits monocyte immigration into the lung: Implications on alveolar space inflammatory responsiveness. Respir Res. 7:30, 2006.
•	Srivastava M, Jung S, Wilhelm J, Fink L, Buhling F, Welte T, Bohle RM, Seeger W, Lohmeyer J, Maus UA. The inflammatory versus constitutive trafficking of mononuclear phagocytes into the alveolar space of mice is associated with drastic changes in their gene expression profiles. J. Immunol. 175: 1884-1893, 2005.
•	Maus UA, Wellmann S, Hampl C, Kuziel WA, Srivastava M, Mack M, Everhart MB, Blackwell TS, Christman JW, Schlondorff D, Bohle RM, Seeger W, Lohmeyer J. CCR2 positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels. Am J Physiol Lung Cell Mol Physiol. 288: L350-358, 2005.
•	Maus UA, Srivastava M, Paton JC, Mack M, Everhart MB, Blackwell TS, Christman JW, Schlöndorff D, Seeger W, Lohmeyer J. Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space. J Immunol. 173: 1307-1312, 2004.