Dr. SYED MUSTHAPA M.
 
Scientist E1
Endocrinology Division
Central Drug Research Institute
Lucknow 226 001.
 
Educational Qualifications M.Sc, Ph.D (Biochemistry)
Date of Birth

04.03.1976

Phone No. +91-522-2612411-18 Ext. 4404
Fax +91-522-2623405
E- mail s.musthapa@cdri.res.in
 
POST DOCTORAL EXPERIENCE
 

Postdoctoral Fellow : University of Alabama at Birmingham, Birmingham, USA, 2005-2006

Research Associate : University of Alabama at Birmingham, Birmingham, USA, 2006-2010.
Assistant Professor : University of Alabama at Birmingham, Birmingham, USA, 2010-03/2011
 
CURRENT AREAS OF INTEREST
 
Studying the novel genetic and epigenetic drug targets in cancer biology
Developing in vitro and in vivo models for cancer prevention and therapy
Studying the mechanistic role of bioactive dietary supplements on cancer prevention and therapy
 
SELECTED PUBLICATIONS (Total no. of publications in peer-reviewed scientific journals: 36)
 
Meeran SM, Patel SN, Chan TH and Tollefsbol T (2011) A Novel Prodrug of Epigallocatechin-3-gallate: Differential Epigenetic hTERT Repression in Human Breast Cancer Cells. Cancer Prev Res. In Press.
Meeran SM, Ahmed A and Tollefsbol T (2010) Epigenetic targets of bioactive dietary components for the cancer prevention and therapy. Clinical Epigenet. 1: 101-116.
Li Y, Yuan YY, Meeran SM and Tollefsbol TO (2010) Synergistic epigenetic reactivation of estrogen receptor-a by combined green tea polyphenols and histone deacetylase inhibitor in ERa-negative breast cancer cells. Molecular Cancer, 9: 274
Meeran SM, Patel SN and Tollefsbol T (2010) Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cells. PLoS ONE. 5(7): e11457.
Sharma SD, Meeran SM and Katiyar SK (2010) Proanthocyanidins Inhibit In vitro and In vivo Growth of Human Non-Small Cell Lung Cancer Cells by Inhibiting the Prostaglandin E2 and Prostaglandin E2 Receptors. Mol Cancer Ther. 9(3): 569-80.
Katiyar SK, Vaid M, van Steeg H and Meeran SM (2010) Green Tea Polyphenols Prevent UV-Induced Immunosuppression by Rapid Repair of DNA Damage and Enhancement of Nucleotide Excision Repair Genes. Cancer Prev Res. 3(2): 179-89.
Meeran SM, Singh T, Nagy TR and Katiyar SK (2009) High-Fat Diet Exacerbates Inflammation and Cell Survival Signals in the Skin of Ultraviolet B-Irradiated C57BL/6 Mice. Toxicol Appl Pharmacol. 241(3): 303-10.
Sharma SD, Meeran SM, Katiyar N, Tisdale B, Yusuf N, Xu H, Elmets CA and Katiyar SK (2009). IL-12-deficiency suppresses 12-O-tetradecanoylphorbol-13-acetate-induced skin tumor development in 7, 12-dimethylbenz (a)anthracene-initiated mouse skin through inhibition of inflammation. Carcinogenesis. 30(11): 1970-7.
Meeran SM, Katiyar N, Singh T and Katiyar SK (2009) Loss of endogenous interleukin-12 activates survival signals in UV-exposed mouse skin and skin tumors. Neoplasia 11(9): 846-55.
Meeran SM, Vaid M, Punathil T and Katiyar SK (2009) Dietary grape seed proanthocyanidins inhibit 12-O-tetradecanoyl phorbol-13-acetate-caused skin tumor promotion in 7, 12-dimethylbenz(a)anthracene-initiated mouse skin, which is associated with the inhibition of inflammatory responses. Carcinogenesis. 30(3): 520-8.
Akhtar S, Meeran SM, Katiyar N and Katiyar SK (2009) Grape seed proanthocyanidins inhibit the growth of human Non-small cell lung cancer xenografts by targeting Insulin-like growth factor binding protein-3, tumor cell proliferation, and angiogenic factors. Clin Cancer Res. 15(3): 821-31
Meeran SM, Akhtar S and Katiyar SK (2009) Inhibition of UVB-Induced Skin Tumor Development by Drinking Green Tea Polyphenols Is Mediated Through DNA Repair and Subsequent Inhibition of Inflammation. J Invest Dermatol. 129(5):1258-70.
Meeran SM, Punathil T and Katiyar SK (2008) IL-12 deficiency exacerbates inflammatory responses in UV-irradiated skin and skin tumors. J Invest Dermatol. 128: 2716-27.
Katiyar SK, Meeran SM, Katiyar N and Akhtar S (2009) p53 cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. Mol. Carcinog. 48(1): 24-37.
Meeran SM, Katiyar S and Katiyar SK (2008) Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation. Toxicol Appl Pharmacol. 229: 33-43.
Meeran SM and Katiyar SK (2008) Cell cycle control as a basis for cancer chemoprevention through dietary agents. Front Biosci. 13: 2191-2202 (Review).
Meeran SM and Katiyar SK (2008) Proanthocyanidin inhibit mitogenic and survival-signalling invitro and tumor growth in vivo. Front Biosci. 13: 887-897.
Meeran SM, Katiyar S, Elmets CA, Katiyar SK. (2007) Interleukin-12 deficiency is permissive for angiogenesis in UV radiation-induced skin tumors. Cancer Res. 15; 67(8):3785-93.
Meeran SM and Katiyar SK (2007) Grape seed proanthocyanidins promote apoptosis in human epidermoid carcinoma A431 cells through alterations in Cdki-Cdk-cyclin cascade, and caspase-3 activation via loss of mitochondrial membrane potential. Exp Dermatol. 16(5):405-15.
Sharma SD, Meeran SM and Katiyar SK (2007). Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-kappaB signaling in in vivo SKH-1 hairless mice. Mol Cancer Ther. ;6(3):995-1005
Katiyar SK and Meeran SM (2007). Obesity increases the risk of UV radiation-induced oxidative stress and activation of MAPK and NF-kappaB signaling. Free Radic Biol Med 42 (2): 299-310.
Meeran SM, Katiyar S, Elmets CA and Katiyar SK (2006). Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice. Mol Cancer Ther 5(7): 1660-1668.
Meeran SM, Mantena SK, Elmets CA and Katiyar SK (2006). (-)-Epigallocatechin-3-gallate prevents photocarcinogenesis in mice through interleukin-12-dependent DNA repair. Cancer Res 66(10): 5512-5520.
Meeran SM, Mantena SK, Meleth S, Elmets CA and Katiyar SK (2006). Interleukin-12-deficient mice are at greater risk of UV radiation-induced skin tumors and malignant transformation of papillomas to carcinomas. Mol Cancer Ther 5(4): 825-832.
Meeran SM, Mantena SK and Katiyar SK (2006). Prevention of ultraviolet radiation-induced immunosuppression by (-)-epigallocatechin-3-gallate in mice is mediated through interleukin 12-dependent DNA repair. Clin Cancer Res 12 (7): 2272-2280.
Mantena SK, Meeran SM, Elmets CA and Katiyar SK (2005). Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors. J Nutr 135(12): 2871-2877.