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DR. ATUL GOEL |
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Principal
Scientist
Medicinal and Process Chemistry Division
Central Drug Research Institute
Lucknow 226001, India
Tel.: 2612411-18 Extn. 4326, 4381 |
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| Educational qualifications |
M.Sc
(Organic Chemistry, University of Lucknow, Lucknow,
India, 1992)
Ph.D. (Chemistry, CSIR-Central Drug
Research Institute, Lucknow, 1998) |
| Date of Birth |
13th March, 1970 |
| E Mail |
goela13@gmail.com;
atul_goel@cdri.res.in
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| POSTDOCTORAL
RESEARCH ( ABROAD) |
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National Cancer Institute,
National Institutes of Health, Bethesda, Maryland, USA
with Dr. Ettore Appella during May 1999 - Oct. 2001 |
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Alexander von Humboldt
Fellow (Experienced Researcher) with Prof. Dr. Dr. h.
c. Gerhard Bringmann, Institute of Organic Chemistry,
University of Wuerzburg, Germany (July 2008-March 2009) |
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Alexander von Humboldt
Visiting Scientist, Institute of Organic Chemistry, University
of Wuerzburg, Germany (Oct. 2010-Dec. 2010) |
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Alexander von Humboldt
Visiting Scientist, Institute of Organic Chemistry, University
of Wuerzburg, Germany (May 2011-July 2011) |
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| CURRENT
AREAS OF INTEREST |
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Development of innovative
routes for biologically important natural and synthetic
products |
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New Fluorescent dyes/probes
for biological and electroluminescent material applications
such as fluorescent sensors, markers, Organic Light Emitting
Diodes (OLEDs) |
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| HONOURS
& AWARD |
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Alexander von
Humboldt Fellowship (Experienced Researcher category)
in 2008 by AvH Stiftung, Bonn, Federal Republic of Germany |
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Dr. Ghanshyam
Srivastava Memorial Award 2007-08 by Indian Chemical
Society of India |
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CDRI Incentive
Award in the years 2006, 2007, 2008, 2009, 2010
and 2011 |
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Ramanna Fellowship
in 2007-2010 by Department of Science and Technology,
New Delhi, India |
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Young Scientist
Award 2005 of Council of Science and Technology
by Chief Minister, Government of Uttar Pradesh, India
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DST Fast Track
Young Scientist Award-2004 |
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National Institutes
of Health Fellowship, USA in 1999 |
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| RESEARCH
APPRECIATION |
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Certificate of Appreciation
for Thesis Advisor of 2009 Eli Lilly and Company Asia
Outstanding Thesis Awardee (Dr. Sumit Chaurasia) |
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Certificate of Appreciation
for Thesis Advisor of 2010 Eli Lilly and Company Asia
Outstanding Thesis Awardee (Dr. Amit Kumar) |
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Our paper on ‘novel
concept’ for inhibiting Green Emission Defect (GED)
(Organic Letters, 2009, 6, 1289) was highlighted by American
Chemical Society (ACS) as significant paper during May
2009. |
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Our article on Yellow
Fluoranthenes (J. Org Chem., 2010, 75, 3656) was highlighted
by American Chemical Society (ACS) as significant paper
during June 2010. |
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The article on Nonaggregating
Blue Pyrenylarenes (J. Org. Chem., 2011, 76, 7474) was
highlighted by American Chemical Society (ACS) as significant
paper during September 2011. |
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RESEARCH
GROUP |
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Former
Ph.D. Students |
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Dr. Fateh Veer Singh (PDF,
FAPESP Fellowship in Brazil, Prestigious Marie Curie Fellowship
with Prof. Thomas Wirth at Cardiff Univeristy,UK) |
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Dr. Manish Dixit (PDF,
Dr. S. Bhattacharya at National Institutes of Health,
NCI, USA) |
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Dr. Deepti Verma (PDF
with Prof. I. N. N. Namboothiri at IIT, Mumbai) |
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Dr. Sumit Chaurasia (PDF
with Prof. J. T. Lin at Academia Sinica, Taipei ) |
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Dr. Amit Kumar (Sr. RA,
GVK Biosciences Pvt. Ltd., Hyderabad) |
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Current
Ph.D. Students |
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Mr. Vijay Kumar (SRF) |
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Mr. Salil Pratap Singh
(SRF) |
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Ms. Amrita Parihar (SRF) |
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Mr. Gaurav Taneja (SRF) |
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Mr. Pankaj Nag (SRF) |
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Mr. Ashutosh Raghuvanshi
(JRF) |
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Mr. Ashutosh Sharma (JRF) |
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Ms. Shahida Umar (JRF) |
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Research
Trainee |
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Mr. Madan Lal Soni (NIPER,
Raibareli) |
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Mr. Govind Tiwari (NIPER,
Raibareli) |
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| RESEARCH
ACTIVITIES |
My research group is mainly focused on two
major topics of organic and medicinal chemistry as mentioned
below: |
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Development
of Innovative Routes for Biologically Important Natural
and Synthetic Products
During drug development program on Reproductive health
including management of osteoporosis and bone related
disorders, CSIR-CDRI research group observed that crude
extract of Butea monosperma exhibited in vitro
and in vivo bone forming (osteoblast mineralization)
activity (Pandey et al. Menopause,
2010, 17, 602-610). Fractionation-guided activity
showed a mixture of five isoflavonoids having good osteogenic
activity. In order to identify the activity of individual
isoflavonoids, high quantities of medicarpin and cajanin
were required. We developed efficient protocol for the
synthesis of these natural isoflavonoids (medicarpin
and cajanin) and their new derivatives, and demonstrated
their differential actions in osteoblasts and parameters
of acquisition of PBM in growing female rats (Tyagi
et al. Molecular and Cellular Endocrinology 2010, 325,
101-109; J. Nutritional Biochemistry, 2011,
in press; Osteoporosis International, 2011, in press).
We further prepared a series of new pterocarpans and
showed that they hold therapeutic promise in postmenopausal
osteoporosis (Goel et al.: Substituted benzofurochromenes
and related compounds for the prevention and treatment
of bone related disorders: PCT filing Appl. No. PCT/IN2009/000285
dated 14-05-09).
New leads such as CDRI S-006-1709, S-007-1500, S-008-398/399
were identified as potent osteogenic agents and one
of the pterocarpans S-007-1500 significantly stimulated
callus formation and increased fracture healing at only
1.0 mg/kg/day dose in adult rats. New bone formation
at the fracture site is increased by ~40% in rats treated
with S-007-1500 compared to vehicle treated rats. These
compounds are currently under development stage and
open for further development and licensing (For further
information, please contact Director, CDRI). |
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Figure.
New bone formation at the fracture site is increased
by ~40% in rats treated with CDRI S007-1500 |
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New
Organic Fluorescent Molecules and their Applications
The use of small molecule organic fluorescent probes
to investigate biological and material phenomena has
become a prominent research approach in chemical biology
and material sciences. The importance of new efficient
fluorescent organic probes is realized due to their
wide application ranging from labeling of amino acids,
peptides, proteins, and chemosensors, biomarkers to
nano-material semiconductors and electroluminescent
materials like organic light emitting devices (OLEDs).
As the demand for fluorescent molecules continues to
grow, the need to develop new methodology for the rapid
generation and evaluation of small molecules has also
become an area of high importance
Our group is engaged in the development of New Organic
Fluorescent Dyes with absorption and emission at variety
of wavelength for biological (as drug candidates or
biomarkers) and material (smart electroluminescent devices)
applications. Very recently we have demonstrated
a novel ‘concept’
of inhibiting “Green Emission Defect” in
fluorene-based OLEDs by transforming “green-yellow”
fluorenone molecules to “blue” fluorenone
compounds by appropriate positioning of donor-acceptor
and chromophoric groups onto widely used fluorene/fluorenone
p-conjugated system (Goel et al. PCT patent WO/2009/122445
dated 08.10.2009; PCT/IN2009/000215 dated 31.03.09).
The performance of a blue fluorene was investigated
by fabricating a multilayer OLED with a configuration
of ITO/PEDOT:PSS/TPD (30nm)/D/A-fluorene (60nm)/BCP
(8nm)/ LiF(0.5nm)/Al (160 nm), which revealed stable
bright blue emission with a low turn on voltage of 3.5V
and a brightness of 573 Cd/m2 with good chemical, thermal
and electrochemical stability (Goel
et al. Organic Letters, 2009, 6, 1289). |
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A novel
approach to inhibit "Green Emission Defect" in fluorene-based
OLEDs |
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Recently we uncovered
the photophysical, optical and electrochemical properties
of interesting non-aggregating and thermally stable blue pyrenylarenes
and demonstrated their potential use in preparing high demanding
blue OLEDs. |
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| Furthermore we showed
donor-acceptor quateraryls with high glass transition temperature
are potential candidates for preparing blue fluorescent stable
light emitting dispalys (Goel et
al. Organic Letters, 2008, 10, 2553; Synfacts, 2008, 9, 935) |
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| We
have recently reported (Goel et al. J.
Org. Chem. 2010, 75, 3656-3662) highly efficient nondoped
fluoranthene-based Yellow OLEDs, which exhibited bright yellow
fluorescence, high quantum efficiency and good thermal stability.
One of the Y-OLEDs showed bright yellow emission with low turn-on
voltage of 2.6V and maximum brightness of 470 Cd/m2 with luminance
efficiency of 2.0 Cd/A (at 5V) without using any dopant. The
series of donor-acceptor fluoranthenes demonstrating emission
in yellow region may solve the problem of dopant aggregation
to large extent. Owing to interesting photophysical, electrochemical
and thermal properties, these compounds may also find application
for developing new yellow fluorescent molecular probes. The
work is currently under progress |
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| SELECTED
PUBLICATIONS |
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Atul
Goel*, Vijay Kumar, Pankaj Nag, Vikas Bajpai,
Brijesh Kumar, Charan Singh, Sattey Prakash, and R. S.
Anand: Thermally Stable Nonaggregating Pyrenylarenes for
Blue Organic Light-Emitting Devices, J.
Org. Chem.,
2011, 76, 7474-7481 |
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Abdul Malik
Tyagi, Kamini Srivastava, Jyoti Kureel, Anuj Kumar Singh,
Kunal Sharan, Amit Kumar, Atul Goel,
Divya Singh: Premature T Cell Senescense in Ovx Mice is
inhibited by repletion of Estrogen and Medicarpin: A Possible
Mechanism for Alleviating Bone Loss, Osteoporosis
International,
2011, in press. |
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Biju Bhargavan,
Divya Singh, Abnish Kumar Gautam, Jay Sharan Mishra, Amit
Kumar, Atul Goel, Manish Dixit, Rashmi
Pandey, Lakshmi Manickavasagam, Shailendra Dhar Dwivedi,
Bandana Chakravarti, Girish Kumar Jain, Ravishankar Ramachandran,
Naibedya Chattopadhyay, Sabyasachi Sanyal: Medicarpin,
a Legume Phytoalexin, Stimulates Osteoblast Differentiation
and Promotes Peak Bone Mass Achievement in Rats: Evidence
for Estrogen Receptor ?-mediated Osteogenic Action of
Medicarpin, J.
Nutritional Biochemistry,
2011, in press. |
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Atul
Goel,* Vijay Kumar, Sumit Chaurasia, Madhu Rawat,
Ramesh Prasad, R. S. Anand: Synthesis, Electrochemical
and Optical Properties of Novel and Stable Yellow Fluorescent
Fluoranthenes, J. Org.
Chem., 2010, 75, 3656-3662. |
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Abdul M Tyagi,;
Abnish K Gautam,; Amit Kumar; Biju Bhargavan; Kamini Srivastava;
Ritu Trivedi; Dinesh K Yadav, S Saravanan, Caroline Pollet,
Michel Brazier, Romuald Mentaverri, Rakesh Maurya, Naibedya
Chattopadhyay, Atul Goel*, Divya Singh*:
Medicarpin inhibits osteoclastogenesis and has nonestrogenic
bone conserving effect in ovariectomized mice, Molecular
and Cellular Endocrinology 2010,
325, 101-109. |
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Goel,
A., Singh, S. P., Kumar, A., Kant, R., Maulik,
P. R.: Unprecedented ‘Bridged Annulation’
Approach to the Construction of 5,6-Dihydro-4H-benzo[kl]acridines.
Organic Letters
2009, 11, 5122-5125. |
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Goel,
A.*, Chaurasia, S., Dixit, M., Kumar, V., Prakash,
S., Jena, B., Verma, J. K., Jain, M., Anand, R. S., Manoharan,
S. S.: Donor-Acceptor 9-Uncapped Fluorenes and Fluorenones
as Stable Blue Light Emitters. Organic
Letters 2009,11, 1289-1292 |
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Goel,
A.; Dixit, M.; Chaurasia, S.; Kumar, A.; Raghunandan,
R.; Maulik, P. R.; Anand, R. S.: Vapor-Phase Processable
Novel Nonplanar Donor-Acceptor Quateraryls for Blue-OLEDs.
Organic
Letters
2008,10, 2553-2556 |
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Goel
Atul, Singh Fateh Veer, Dixit Manish, Verma Deepti,
Raghunandan Resmi and Maulik Prakas R. - Highly efficient
non-palladium-catalyzed controlled synthesis and X-ray
analysis of functionalized 1,2-diaryl-, 1,2,3-triaryl-,
and 1,2,3,4-tetraarylbenzenes.
Chemistry-An Asian Journal 2007,
2, 239-247 |
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Goel
Atul, Singh FV, Kumar V, Reichert M, Gulder TA
and Bringmann G. - Synthesis, optical resolution and configurational
assignment of novel axiallychiral quateraryls. 2007, J.
Org. Chem., 72, 7765-7768 |
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Atul
Goel,* Deepti Verma, Manish Dixit, Resmi Raghunandan,
P. R. Maulik: Acetyltrimethylsilane: A Novel Reagent for
the Transformation of 2H-Pyran-2-ones to Unsymmetrical
Biaryls J. Org. Chem.,
2006, 71, 804-807. |
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Farhanullah,
Agarwal, N., Goel, A., Ram, V.J.: A concerted
synthesis of aminonicotinonitriles and diaminopyridines
through base catalyzed ring transformation of 2H-Pyran-2-ones.
J. Org. Chem.
2003, 68, 2983-2985 |
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