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| Dr.
ANIL KUMAR SAXENA |
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Scientist - G
Scientist-in-Charge
Medicinal Chemistry Division,
Central Drug Research Institute
Lucknow 226 001 (India) |
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| POST
DOCTORAL EXPERIENCE |
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As Alex.
V. Humboldt Fellow |
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Borstel Research
Institute, Germany |
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| RESEARCH
EXPERIENCE |
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39 Year's
research experience in Medicinal Chemistry & 25 years
in CADD & CAMM. |
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| CURRENT
AREAS OF INTEREST |
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Medicinal
Chemistry & Computer Aided Drug Design (CADD). |
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| EDITOR
BOOKS/ JOURNALS |
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Guest Editor |
Medicinal
Chemistry Research, Vol. 5, No. 8, 1995 |
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Guest Editor |
Medicinal
Chemistry Research, Vol. 10, number 7/8, 2001, Birkhauser
Publication, USA. |
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Guest Editor |
SAR and QSAR
in Environmental Research, Vol. 12, number 6, 2001. |
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Patent Evaluator |
Current Drugs,
U.K. |
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| SELECTED
RESEARCH PAPERS |
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Substituted
1, 2, 3, 4-Tetrahydroquinolin-6-yloxypropanes as ß3-adrenergic
receptor agonists: Design, synthesis, biological evaluation
and pharmacophore modeling Neeraj Shakya, Kuldeep K. Roy
and A.K. Saxena Bioorg. & Med. Chem.
17, 830-847, 2009. |
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2D-QSAR of purine-scaffold
novel class of Hsp90 binders that inhibit the proliferation
of cancer cells Supriya Singh and A.K. Saxena
Med. Chem. Res., 17, 290-296, 2008. |
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2D-QSAR studies on new
stilbene derivatives of resveratrol as a new selective
aryl hydrocarbon receptor Tanvee Tripathi, A.K.
Saxena Med. Chem. Res., 17, 212-218,
2008. |
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2-Thiazolylimino/Heteroarylimino-5-arylidene-4-thiazolidinones
as New Agents with SHP-2 Inhibitory Action A. Geronikaki,
P. Eleftheriou, P. Vicini, I. Alam, A. Dixit and A.K.
Saxena J. Med. Chem., 51, 5221–5228,
2008. |
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An investigation of structurally
diverse carbamates for acetylcholinesterase (AChE) inhibition
using 3D-QSAR analysis Kuldeep K. Roy, Anshuman Dixit,
Anil K. Saxena J. Mol. Graph.
and Model., 27, 197-208, 2008. |
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Synthesis and QSAR studies
of thiosemicarbazides, 1,2,4-triazoles, 1,3,4-thiadiazoles
and 1,3,4-oxadiazoles derivatives as potential antibacterial
agents. N.C. Desai, A.M. Bhavsar, M.D. Shah &
A.K. Saxena Ind. J. Chem. 47B, 579-585, 2008. |
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Computer-Aided Discovery
of Anti-Inflammatory Thiazolidinones with Dual Cyclooxygenase/
Lipoxygenase Inhibition A.A. Geronikaki, A.A. Lagunin,
D.I. Hadjipavlou-Litina, P.T. Eleftheriou, D.A. Filimonov,
V.V. Poroikov, I. Alam, and A.K. Saxena J. Med. Chem.
51, 1601–1609, 2008. |
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Internet resources in
GPCR modeling A.K. Saxena, I. Alam, A.
Dixit and M. Saxena SAR and QSAR in Environmental
Research 25, 11-25, 2008. |
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QSAR analysis of PPAR-?
agonists as anti-diabetic agents A. Dixit and
A.K. Saxena Eur. J. Med. Chem. 43, 73-80, 2008. |
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Rational design, synthesis
and evaluation of (6aR*,11bS*)-1-(4- fluorophenyl)-4-{7-[4-(4-fluoro-phenyl)-4-oxobutyl]1,2,3,4,6,6a,7,
11b,12,12a(RS)-decahydropyrazino-[2',1':6,1]pyrido[3,4-b]indol-
2-yl}-butan-1-one as a potential neuroleptic agent R.
Chakrabarty, J. Rao, A. Anand, A. Deb Roy, R.Roy, G. Shankar,
P.R. Dua and Anil K. Saxena Bioorg. & Med.
Chem. 15, 7361-7367, 2007. |
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Investigation of the barrier
to the rotation of carbamate and amide C–N bonds
in antidepressant (6aR*,11bS*)-7-[carbobenzyloxy-l-alanyl]-2-[(4-methylphenyl)sulfonyl]-1,2,3,4,6,6a,7,11b,2,12a(S)-decahydropyrazino[2',1':6,1]pyrido[3,4-b]indole
by dynamic NMR and molecular mechanics A. Anand, A.D.
Roy, R. Chakrabarty, A.K. Saxena and
R. Roy Tetrahedron, 63, 5236–5243,
2007. |
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Synthesis and QSAR studies
on hypotensive 1-[3-(4-substituted phenylthio) propyl]-4-(substituted
phenyl) piperazines A.K. Saxena, J. Rao,
R. Chakrabarty, M. Saxena and R.C. Srimal Bio.
and Med. Chem. Letter, 17, 1708-1712, 2007. |
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Computer-aided drug design:
Integration of structure-based and ligand-based approaches
in drug design P. Prathipati, A. Dixit and A.K.
Saxena Curr. Comp.Aided Drug Design
3, 341-352, 2007. |
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a-Amino acid derivatives
as proton pump inhibitors and potent anti-ulcer agents
P. Sharma, S. Singh, T.I. Siddiqui, V.S. Singh, B. Kundu,
P. Prathipati, A.K. Saxena, D.K. Dikshit,,
L. Rastogi, C. Dixit, M.B. Gupta, G.K. Patnaik & M.
Dikshit Eur. J. Med. Chem. 42, 386-393,
2007. |
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BIOSUITE: A Comprehensive
bioinformatics software suite A. Dixit, P. Prathipati,
S. Kashaw, A.K. Saxena, M. Vidyasagar,
P.V. Bharatam, … et al. Current Science,
92, 29-38, 2007. |
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Synthesis of some substituted
pyrazinopyridoindoles and 3D QSAR studies along with related
compounds: Piperazines, piperidines, pyrazinoisoquinolines,
and diphenhydramine, and its semi-rigid analogs as antihistamines
(H1) M. Saxena, S. Gaur, P. Prathipati and A.K.
Saxena, Bioorg. and Med. Chem. 14, 8249-8258,
2006. |
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3D-QSAR Studies on Protein
Tyrosine Phosphatase 1B Inhibitors: Comparison of the
Quality and Predictivity among 3D QSAR Models Obtained
From Different Conformer Based Alignment. Gyanendra Pandey
& A.K. Saxena, J. Chem. Inf. Model.
46, 2579-2590, 2006. |
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Collection and preparation
of molecular databases for virtual screening A.K.
Saxena, P. Prathipati SAR and QSAR in
Environmental Research 17, 371-392, 2006 |
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QSAR analysis of the time-
and dose-dependent anti-inflammatory in vivo activity
of substituted-imidazo[1,2-a]pyridines using artificial
neural networks A.K. Saxena and K.-J.
Schaper QSAR Comb. Sci. 25, 590-597,
2006 |
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QSAR studies on cis-hexa
and tetrahydrophthalazinones: A new class of PDE-4 inhibitors.
M. Lakshmi, A. Dixit and A.K. Saxena,
Ind. J. Chem., 45A, 34-45, 2006. |
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Evaluation of binary QSAR
models derived from LUDI and MOE scoring functions for
structure based virtual screening. P. Prathipati and A.K.
Saxena, J. Chem. Inf. Model.,
46, 39-51, 2006. |
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Characterization of beta3
Adrenergic Receptor: Determination of Pharmacophore and
3D QSAR models for ?3 Adrenergic Receptor Agonism P. Prathipati
and A.K. Saxena, J. Comp. Aided Mol. Design,
19, 93-110, 2005. |
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Design and synthesis of
new antihistamines as malarial choloroquin resistance
reversal agents M. Saxena, R. Chakravarty, S. Gaur, R.
Raghubir, S.K. Puri and A.K. Saxena Infection,
33, 198, 2005. |
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Computer aided molecular
modelling studies in anti-tubercular agent: Pharmacophore
and CoMFA models of pyrazinamides (PZA analogues) A.K.
Saxena Infection, 33, 194, 2005. |
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CoMFA and docking studies
on Glycogen Phosphorylase a inhibitors as antidiabetic
agents P. Prathipati G. Pandey and A.K. Saxena
J. Chem. Inf. Model., 45, 136 -145, 2005 |
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| RESEARCH
OUTPUT |
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Research papers
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131 |
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Review/articles
in Books/Monographs |
18 |
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Patents (Granted/
filed) |
67 |
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Papers presented
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120 |
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Invited lectures |
108 |
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