Dr. ANIL KUMAR SAXENA
 


Scientist - G
Scientist-in-Charge
Medicinal Chemistry Division,
Central Drug Research Institute
Lucknow 226 001 (India)
 
Phone No. +91-522-2212411-18; Extn. 4268 , +91-522-351638
Fax No. +91-522-223405
E- mail ak_saxena@cdri.res.in anilsak@]hotmai.com
Educational Qualifications M.Sc. Ph.D.
Date of Birth

17- 12- 1951

 
POST DOCTORAL EXPERIENCE
 
As Alex. V. Humboldt Fellow
Borstel Research Institute, Germany
 
RESEARCH EXPERIENCE
 
39 Year's research experience in Medicinal Chemistry & 25 years in CADD & CAMM.
 
CURRENT AREAS OF INTEREST
Medicinal Chemistry & Computer Aided Drug Design (CADD).
EDITOR BOOKS/ JOURNALS
 
Guest Editor Medicinal Chemistry Research, Vol. 5, No. 8, 1995
Guest Editor Medicinal Chemistry Research, Vol. 10, number 7/8, 2001, Birkhauser Publication, USA.
Guest Editor SAR and QSAR in Environmental Research, Vol. 12, number 6, 2001.
Patent Evaluator Current Drugs, U.K.
 
 
SELECTED RESEARCH PAPERS
 
Substituted 1, 2, 3, 4-Tetrahydroquinolin-6-yloxypropanes as ß3-adrenergic receptor agonists: Design, synthesis, biological evaluation and pharmacophore modeling Neeraj Shakya, Kuldeep K. Roy and A.K. Saxena Bioorg. & Med. Chem. 17, 830-847, 2009.
2D-QSAR of purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells Supriya Singh and A.K. Saxena Med. Chem. Res., 17, 290-296, 2008.
2D-QSAR studies on new stilbene derivatives of resveratrol as a new selective aryl hydrocarbon receptor Tanvee Tripathi, A.K. Saxena Med. Chem. Res., 17, 212-218, 2008.
2-Thiazolylimino/Heteroarylimino-5-arylidene-4-thiazolidinones as New Agents with SHP-2 Inhibitory Action A. Geronikaki, P. Eleftheriou, P. Vicini, I. Alam, A. Dixit and A.K. Saxena J. Med. Chem., 51, 5221–5228, 2008.
An investigation of structurally diverse carbamates for acetylcholinesterase (AChE) inhibition using 3D-QSAR analysis Kuldeep K. Roy, Anshuman Dixit, Anil K. Saxena J. Mol. Graph. and Model., 27, 197-208, 2008.
Synthesis and QSAR studies of thiosemicarbazides, 1,2,4-triazoles, 1,3,4-thiadiazoles and 1,3,4-oxadiazoles derivatives as potential antibacterial agents. N.C. Desai, A.M. Bhavsar, M.D. Shah & A.K. Saxena Ind. J. Chem. 47B, 579-585, 2008.
Computer-Aided Discovery of Anti-Inflammatory Thiazolidinones with Dual Cyclooxygenase/ Lipoxygenase Inhibition A.A. Geronikaki, A.A. Lagunin, D.I. Hadjipavlou-Litina, P.T. Eleftheriou, D.A. Filimonov, V.V. Poroikov, I. Alam, and A.K. Saxena J. Med. Chem. 51, 1601–1609, 2008.
Internet resources in GPCR modeling A.K. Saxena, I. Alam, A. Dixit and M. Saxena SAR and QSAR in Environmental Research 25, 11-25, 2008.
QSAR analysis of PPAR-? agonists as anti-diabetic agents A. Dixit and A.K. Saxena Eur. J. Med. Chem. 43, 73-80, 2008.
Rational design, synthesis and evaluation of (6aR*,11bS*)-1-(4- fluorophenyl)-4-{7-[4-(4-fluoro-phenyl)-4-oxobutyl]1,2,3,4,6,6a,7, 11b,12,12a(RS)-decahydropyrazino-[2',1':6,1]pyrido[3,4-b]indol-
2-yl}-butan-1-one as a potential neuroleptic agent R. Chakrabarty, J. Rao, A. Anand, A. Deb Roy, R.Roy, G. Shankar, P.R. Dua and Anil K. Saxena Bioorg. & Med. Chem. 15, 7361-7367, 2007.
Investigation of the barrier to the rotation of carbamate and amide C–N bonds in antidepressant (6aR*,11bS*)-7-[carbobenzyloxy-l-alanyl]-2-[(4-methylphenyl)sulfonyl]-1,2,3,4,6,6a,7,11b,2,12a(S)-decahydropyrazino[2',1':6,1]pyrido[3,4-b]indole by dynamic NMR and molecular mechanics A. Anand, A.D. Roy, R. Chakrabarty, A.K. Saxena and R. Roy Tetrahedron, 63, 5236–5243, 2007.
Synthesis and QSAR studies on hypotensive 1-[3-(4-substituted phenylthio) propyl]-4-(substituted phenyl) piperazines A.K. Saxena, J. Rao, R. Chakrabarty, M. Saxena and R.C. Srimal Bio. and Med. Chem. Letter, 17, 1708-1712, 2007.
Computer-aided drug design: Integration of structure-based and ligand-based approaches in drug design P. Prathipati, A. Dixit and A.K. Saxena Curr. Comp.Aided Drug Design 3, 341-352, 2007.
a-Amino acid derivatives as proton pump inhibitors and potent anti-ulcer agents P. Sharma, S. Singh, T.I. Siddiqui, V.S. Singh, B. Kundu, P. Prathipati, A.K. Saxena, D.K. Dikshit,, L. Rastogi, C. Dixit, M.B. Gupta, G.K. Patnaik & M. Dikshit Eur. J. Med. Chem. 42, 386-393, 2007.
BIOSUITE: A Comprehensive bioinformatics software suite A. Dixit, P. Prathipati, S. Kashaw, A.K. Saxena, M. Vidyasagar, P.V. Bharatam, … et al. Current Science, 92, 29-38, 2007.
Synthesis of some substituted pyrazinopyridoindoles and 3D QSAR studies along with related compounds: Piperazines, piperidines, pyrazinoisoquinolines, and diphenhydramine, and its semi-rigid analogs as antihistamines (H1) M. Saxena, S. Gaur, P. Prathipati and A.K. Saxena, Bioorg. and Med. Chem. 14, 8249-8258, 2006.
3D-QSAR Studies on Protein Tyrosine Phosphatase 1B Inhibitors: Comparison of the Quality and Predictivity among 3D QSAR Models Obtained From Different Conformer Based Alignment. Gyanendra Pandey & A.K. Saxena, J. Chem. Inf. Model. 46, 2579-2590, 2006.
Collection and preparation of molecular databases for virtual screening A.K. Saxena, P. Prathipati SAR and QSAR in Environmental Research 17, 371-392, 2006
QSAR analysis of the time- and dose-dependent anti-inflammatory in vivo activity of substituted-imidazo[1,2-a]pyridines using artificial neural networks A.K. Saxena and K.-J. Schaper QSAR Comb. Sci. 25, 590-597, 2006
QSAR studies on cis-hexa and tetrahydrophthalazinones: A new class of PDE-4 inhibitors. M. Lakshmi, A. Dixit and A.K. Saxena, Ind. J. Chem., 45A, 34-45, 2006.
Evaluation of binary QSAR models derived from LUDI and MOE scoring functions for structure based virtual screening. P. Prathipati and A.K. Saxena, J. Chem. Inf. Model., 46, 39-51, 2006.
Characterization of beta3 Adrenergic Receptor: Determination of Pharmacophore and 3D QSAR models for ?3 Adrenergic Receptor Agonism P. Prathipati and A.K. Saxena, J. Comp. Aided Mol. Design, 19, 93-110, 2005.
Design and synthesis of new antihistamines as malarial choloroquin resistance reversal agents M. Saxena, R. Chakravarty, S. Gaur, R. Raghubir, S.K. Puri and A.K. Saxena Infection, 33, 198, 2005.
Computer aided molecular modelling studies in anti-tubercular agent: Pharmacophore and CoMFA models of pyrazinamides (PZA analogues) A.K. Saxena Infection, 33, 194, 2005.
CoMFA and docking studies on Glycogen Phosphorylase a inhibitors as antidiabetic agents P. Prathipati G. Pandey and A.K. Saxena J. Chem. Inf. Model., 45, 136 -145, 2005
 
RESEARCH OUTPUT
 
Research papers 131
Review/articles in Books/Monographs 18
Patents (Granted/ filed) 67
Papers presented 120
Invited lectures 108