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ASHISH ARORA |
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| E- Mail |
ashishcdri[at]yahoo dot com |
| Educational Qualifications |
PhD in Biotechnology from
Panjab University (1996), MSc in Organic Chemistry from
Rajasthan University (1990) |
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| CURRENT AREAS
OF INTEREST |
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Cloning, Expression
and Purification of M. tuberculosis proteins. |
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NMR Spectroscopy
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Fluorescence
and CD spectroscopy |
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Structural
Genomics of Mycobacterium tuberculosis Proteins by NMR
Spectroscopy |
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| Structural
Genomics of Mycobacterium tuberculosis Proteins by NMR Spectroscopy |
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Our aim is to clone, express and isotopically
label important protein drug targets of Mycobacterium
tuberculosis, for determination of their structures
by NMR spectroscopy, and use the structural information
in subsequent high-throughput screening for drug development.
Currently, I am directly supervising three graduate
(Ph.D.) students. I am also involved in planning the
NMR facility for protein structure determination at
CDRI, Lucknow. We are also interested in studying the
thermodynamic stability of protein and protein-ligand
complexes using a variety of biophysical methods.
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| RECENT PUBLICATIONS |
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ASHISH ARORA,
I. M. Williamson, A. G. Lee, and D. Marsh
Lipid-protein interactions with cardiac phospholamban
studied by spin-label electron spin resonance.Biochemistry
(2003), 42, 5151-8. |
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ASHISH ARORA
and L. K. Tamm, Biophysical approaches for membrane protein
structure determination. Curr. Opin. Struct. Biol. (2001)
11, 540-547. |
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L.K. Tamm,
ASHISH ARORA and J.H. Kleinschmidt , Structure and assembly
of -barrel membrane proteins. J. Biol. Chem. (2001), 276(35),
32399-402.
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ASHISH ARORA,
F. Abildgaard, J.H. Bushweller and L.K. Tamm, Structure
of the outer membrane protein A transmembrane domain by
NMR spectroscopy. Nature Struct. Biol. (2001), 8(4), 334-338. |
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ASHISH ARORA,
D. Rinehart, G. Szabo and Lukas K. Tamm, Refolded Outer
membrane protein A of Escherichia coli forms ion channels
with two conductance states in planar lipid bilayers.
J. Biol. Chem. (2000) 275(3), 1594-1600. |
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