Dr. ARUN KUMAR SHAW
 


Scientist E II
Medicinal and Process Chemistry Division
Central Drug Research Institute
Lucknow-226001, India
 
Educational qualifications M.Sc. Ph.D.
Date of Birth July 07, 1955.
Phone Nos. +91-0522-2612411-18-Ext 4334, Mobile + 9415403775
Fax No. +91-0522-2623405
E- mail akshaw55[at]yahoo dot com
 
RESEARCH EXPERIENCE
 
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 Natural Products Chemistry (25 years), Synthetic Organic Chemistry (18 years), Medicinal Chemistry (14 years).
 
POST DOCTORAL RESEARCH
 
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 CSIR-DAAD Visiting Scientist, University of Rostock, Germany, April-June 2000
 
CURRENT AREAS OF RESEARCH
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 Design, Synthesis & Development of Target- based Anti-tubercular agents
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 Synthetic Carbohydrate & Natural Products Chemistry
 
GROUP MEMBERS
 
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 Currently supervising eight research students for their Ph D degree
SELECTED PUBLICATIONS
 
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 “Studies on Tetrahydrofuran based highly O-Functionalized Alkynes: Applications to Synthesis of Tetrahydrofuran Symmetrical, Unsymmetrical Polyynes and C nucleoside analogues” P. Venkat Reddy, V. Bajpai, B. Kumar, A. K. Shaw. Accepted Article. Eur. J. Org. Chem. 2011
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 “A Convergent Total Synthesis of a New Antiepileptic Ceramide and its Triacetyl Derivative Using Olefin Cross Metathesis” Partha Ghosal, Vikas Kumar and Arun K. Shaw Tetrahedron 2010, 66, 7504-7509.
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 “An efficient total synthesis of the anticancer agent (+)-spisulosine (ES-285) from Garner’s aldehyde” Partha Ghosal, Arun K. Shaw* Tetrahedron Letters 2010, 51, 4140-4142.
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 “Synthesis and biological evaluation of glycal-derived novel tetrahydrofuran 1,2,3-triazoles by ‘click’ chemistry” L. Vijaya Raghava Reddy, P. Venkat Reddy, Nripendra N. Mishra, Praveen K. Shukla, Garima Yadav, Ranjana Srivastava, Arun K. Shaw, Carbohydrate Research 2010, 345 ,1515-1521
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 “A chiron approach to the total synthesis of cytotoxic (+)-muricatacin and (+)-5-epi- muricatacin from D-ribose” P. Ghosal, V. Kumar, A. K. Shaw Carbohydrate Research 2010, 345, 41-44.
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 “Facile Synthesis of Enantiomerically Pure 2- and 2,3-Disubstituted Furans Catalysed by Mixed Lewis Acids: An Easy Route to 3-Iodofurans and 3-(Hydroxymethyl)furans” M. Saquib, I. Husain, B. Kumar, A. K. Shaw Chem. Eur. J. 2009, 15, 6041-6049.
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 “Synthesis of enantiomerically pure highly functionalized furanoid glycals and 2,5-dihydrofurans building blocks” P. Pal, B. Kumar, A. K. Shaw Eur. J. Org. Chem. 2009, 2179-2184.
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 Kumar Vikas and Shaw Arun K - First total synthesis of (+)-Varitriol (2008) - J. Org. Chemistry 73, 7526-7531
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 Reddy L Vijaya Raghava, Swamy G Narayana and Shaw Arun K - A versatile route for the stereoselective synthesis of oxybiotin. (2008) - Tetrahedron Asymmetry 19, 1372-1375
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 Reddy P Venkat, Reddy L Vijaya, Raghava, Kumar Brijesh, Kumar Rishi, Maulik Prakas R and Shaw Arun K. - A general and efficient stereoselective synthesis of ?-azido-tetrahydrofuran carboxylic acids from glycals (2008) - Tetrahedron 64, 2153-2159
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 Kumar Vikas, Gauniyal Harsh Mohan and Shaw Arun K. - An iodocyclization approach toward diastereoselective synthesis of highly functionalized tetrasubstituted tetrahydrofurans with 2,5-trans and 2,5-cis relationships from pyranoside derived acyclic oximes. (2007) - Tetrahedron Asymmetry 18, 2069-2078
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 Reddy L Vijaya Raghava, Reddy Venkat P and Shaw Arun K - An expedient route for the practical synthesis of pachastrissamine (jaspine B) starting from 3,4,6-tri-O-benzyl-d-galactal. (2007) - Tetrahedron Asymmetry 18, 542-546
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 Saquib M, Gupta MK, Sagar R, Prabhakar YS, Shaw AK, Kumar R, Maulik PR, Gaikwad AN, Sinha S, Srivastava AK, Chaturvedi V, Srivastava R and Srivastava BS - C-3 alkyl/arylalkyl-2,3-dideoxy hex-2-enopyranosides as antitubercular agents: Synthesis, biological evaluation, and QSAR study. (2007) - Journal of Medicinal Chemistry 50, 2942-2950
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 Stereoselective synthesis of highly O-functionalized enantiopure 2,3,4- trisubstituted tetrahydrofurans by tandem debenzylative cyclization of glycal derived 2,3-epoxy alcohols. L. Vijaya Raghava Reddy, Abhijeet Deb Roy, Raja Roy and Arun K. Shaw. Chem. Commun. 2006, 3444-3446.
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 Studies on epoxidation of enantiomerically pure 2,3-dideoxy hex-2-enitols: a convenient access to highly functionalized enantiomerically pure tetrahydrofuran derivatives. Ram Sagar, L. Vijaya Raghava Reddy and Arun K. Shaw. Tetrahedron: Asymmetry 2006, 17, 1189-1198.
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 An efficient synthesis of 2,3-dideoxy-?,ß-unsaturated carbohydrate enals by mixed Lewis acid (HfCl4 and ZnI2) catalyzed hydration of glycals. Mohammad Saquib, Ram Sagar, Arun K. Shaw. Carbohydr. Res. 2006, 341, 1052-1056.
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 Reductive opening of glycal derived highly functionalized 2,3-epoxy-1-iodides with zinc dust: an efficient method for the synthesis of acyclic long chain polyhydroxylated terminal alkenic alcohols. L.Vijaya Raghava Reddy, Ram Sagar, Arun. K. Shaw. Tetrahedron Lett. 2006, 47, 1753-1756.
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 Neridienone A, a pregnane from the roots of Nerium oleander. Rishi Kumar, Ram Sagar, Arun. K. Shaw, Prakas. R. Maulik. Acta Cryst. 2005, E61, o3905-o3907.
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 CP-MLR directed QSAR studies on the antimycobacterial activity of functionalized alkenols-topological descriptors in modeling the activity. Manish K. Gupta, Ram Sagar, Arun K. Shaw and Yenamandra S. Prabhakar* Bioorganic & Medicinal Chemistry (2005), 13, 343-351
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 Diastereoselective annulation of 4-hydroxypyran-2H-ones with enantiopure 2,3-dideoxy- -unsaturated sugar aldehydes derived from respective glycals. Ram Sagar, Pushpa Singh, Rishi Kumar, Prakas R. Maulik and Arun K. Shaw* Carbohydrate Research (2005), 340, 1287-1300
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 A convenient approach towards separation and identification of triterpenes of delta12 lupane series. Ram Sagar, Namrata Dilip Dhoke and Arun K Shaw. Indian Journal Chem Sec. B, (2004), 43B, 2446-2451.
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 Substrate Controlled A Very High Diastereoselective Mortia-Baylis-Hillman Reaction: A Remote Activation on the Diastereoface Selectivity in Synthesis of C-3-Branched Deoxysugars. Ram Sagar, C.S. Pant and R. Pathak and A.K. Shaw. Tetrahedron (2004), 60, 11399-11406.
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 Reinvestigation of the mercuration-demercuration reaction on alkylated glycals: an improved method for the preparation of 2,3-dideoxy-alpha, beta-unsaturated carbohydrate enals. Ram Sagar, Rashmi Pathak and Arun K. Shaw. Carbohydrate Research (2004), 339, 2031-2035.
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 A Common Sugar as Model for Many - sided Natural Product Modification. From D - Fructose via D - Tagatose to 2 - Difluoro - chloromethylated D - Arabinohexopyranos - 5 - ulose Derivatives, R. Miethchen, S. Tews, A. K. Shaw, S. Röttger, H. Reinke. J. Carbohydr. Chem.(2004), 23, 147- 161.
 
PATENT FILED
 
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 Novel series of unsaturated C-3 aryl and alkyl substituted 2,3- dideoxy glucopyranosides as potential anti-tubercular agents. Ram Sagar, Mohd Saquib, Arun K Shaw, Anil N Gaikwad, Sudhir K Sinha, Anil Srivastava, Vinita Chaturvedi, Manju Y K, Ranjana Srivastava and B S Srivastava.