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DR. ARUN TRIVEDI |
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Scientist C
DTDD Division
Central Drug Research Institute
LUCKNOW
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| AREA OF RESEARCH SPECIALIZATION |
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Molecular biology of Acute Myeloid Leukemia (AML) and
role of C/EBPalpha in leukemogenesis. |
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| CURRENT AREA OF RESEARCH
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Molecular
biology and pathogenesis of breast cancer; Mechanism of
action of anti cancer drugs/compounds using mass spectrometry
based proteomics approach. |
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Screening of clinically validated compounds for their ability to induce differentiation and or apoptosis in myeloid leukemia cells. |
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Identification of interacting proteins of C/EBPalpha and their role in myeloid differentiation and leukemogenesis: A mass spectrometry based proteomics approach. |
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| POST DOCTORAL EXPERIENCE |
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State Center for Cell and Gene Therapy, Martin Luther Univiersity (MLU), Halle, Germany |
Identification
of C/EBP alpha multiprotein complex from CD34+ cells |
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| LAB MEMBERS |
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Pooja Pal, ICMR-SRF
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Jitendra Kanaujiya, CSIR-SRF |
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Savita Lochab, CSIR-SRF |
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Shahsi Tripathi, CSIR-JRF |
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Isha Kapoor, ICMR-JRF |
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| SELECTED
PUBLICATIONS |
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Bile Acid Receptor Agonist GW4064 Regulates PPAR{gamma} Coactivator-1{alpha} Expression Through Estrogen Receptor-Related Receptor {alpha}.
Dwivedi SK, Singh N, Kumari R, Mishra JS, Tripathi S, Banerjee P, Shah P, Kukshal V, Tyagi AM, Gaikwad AN, Chaturvedi RK, Mishra DP, Trivedi AK, Sanyal S, Chattopadhyay N, Ramachandran R, Siddiqi MI, Bandyopadhyay A, Arora A, Lundåsen T, Anakk SP, Moore DD, Sanyal S. Mol Endocrinol. 2011 Apr 14. [Epub ahead of print] |
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Medicarpin, a legume phytoalexin, stimulates osteoblast differentiation and promotes peak bone mass achievement in rats: evidence for estrogen receptor β-mediated osteogenic action of medicarpin.
Bhargavan B, Singh D, Gautam AK, Mishra JS, Kumar A, Goel A, Dixit M, Pandey R, Manickavasagam L, Dwivedi SD, Chakravarti B, Jain GK, Ramachandran R, Maurya R, Trivedi A, Chattopadhyay N, Sanyal S. J Nutr Biochem. 2011 Feb 16. [Epub ahead of print] |
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2-D gel electrophoresis-based proteomic analysis reveals that ormeloxifen induces G0-G1 growth arrest and ERK-mediated apoptosis in chronic myeloid leukemia cells K562.
Pal P, Kanaujiya JK, Lochab S, Tripathi SB, Bhatt ML, Singh PK, Sanyal S, Trivedi AK. Proteomics. 2011 Apr;11(8):1517-29. doi: 10.1002/pmic.201000720. Epub 2011 Feb 25. |
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Proteomic approaches in myeloid leukemia.Kanaujiya JK, Lochab S, Pal P, Christopeit M, Singh SM, Sanyal S, Behre G, Trivedi AK. Electrophoresis. 2011 Feb;32(3-4):357-67. doi: 10.1002/elps.201000428. Epub 2011 Jan 20.
PMID: 21254132 [PubMed - in process] |
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Synthesis and cytotoxicity evaluation of (tetrahydro-beta-carboline)-1,3,5-triazine hybrids as anticancer agents.
Kumar R, Gupta L, Pal P, Khan S, Singh N, Katiyar SB, Meena S, Sarkar J, Sinha S, Kanaujiya JK, Lochab S, Trivedi AK, Chauhan PM. Eur J Med Chem. 2010 Jun;45(6):2265-76. Epub 2010 Feb 10. |
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Ectopic expression of hC/EBPs in breast tumor cells induces apoptosis.
Pal P, Lochab S, Kanaujiya J, Sanyal S, Trivedi AK. Mol Cell Biochem. 2010 Apr;337(1-2):111-8. Epub 2009 Oct 23. |
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Proteomics of AML1/ETO Target Proteins: AML1–ETO Targets a C/EBP–NM23 Pathway.Arun Kumar Trivedi, Sheo Mohan Singh,Savita Lochab,Maximilian Christopeit,Wolfgang Hiddemann and Gerhard Behre.
Clin Proteom 2010 Volume 6, Number 3, 83-91. |
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Proteomic Identification
Of Histone Acetyltransferase TIP60 As a Coactivator Of
Myeloid Transcription Factor C/EBPalpha” Bararia
D, Trivedi AK, Zada AA, Greif PA, Mulaw
MA, Christopeit M, Hiddemann W, Bohlander SK, Behre G.
Leukemia. 2008 Apr;22(4):800-7 |
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Multiple Ways of C/EBPalpha
inhibition in Acute Myeloid Leukemia”
Trivedi
AK, Pal P, Behre G, Singh SM. Eur J Cancer.
2008 Jul;44(11):1516-23. |
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C/EBPalpha S248A mutation
reduces granulocytic differentiation in human leukemic
K562 cells”.
Singh SM, Trivedi AK, Behre G. Biochem
Biophys Res Commun. 2008 May 2;369(2):692-4. |
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Target proteins of C/EBP{alpha}-p30
in AML: C/EBP{alpha}-p30 enhances Sumoylation of C/EBP{alpha}-p42
via up regulation of Ubc9”. Geletu M, Balkhi MY,
Peer Zada AA, Christopeit M, Anto Pulikkan J, Trivedi
AK, Tenen DG, Behre G; Blood. 2007
Nov 1;110(9):3301-9 |
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Proteomic
Identification of C/EBP-DBD Multiprotein Complex: JNK1
Activates Stem Cell Regulator C/EBPalpha by Inhibiting
its Ubiquitination": Trivedi AK,
Deepak Bararia, Christopeit M, Abdul A. PeerZada, Sheo
M Singh, Arnd Kieser, Hiddemann W, Hermann M Behre, Gerhard
Behre; Oncogene. 2007 Mar 15; 26(12):1789-801 |
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"Proteomics of Acute
Myeloid Leukemia: Cytogenetic Risk Groups Differ Specifically
in their Proteome, Interactome and Posttranslational Protein
Modifications: Mumtaz Yaseen, Trivedi AK,
Mulu Geletu, Abdul A Peer Zada, Maximilian Christopeit,
Herman Behre, Gerhard Behre; Oncogene. 2006
Nov 9; 25(53):7041-58. |
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“Proteomic discovery
of Max as a novel interacting partner of C/EBPalpha: a
Myc/Max/Mad link”
Zada AA, Pulikkan JA, Bararia D, Geletu M, Trivedi
AK, Balkhi MY, Hiddemann WD, Tenen DG, Behre
HM, Behre G. Leukemia. 2006 Dec; 20(12):2137-46. |
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