| (M/E Ratio) |
Assays |
Bone Marrow toxicity |
Quantity |
Scientist |
Clonogenic Assays
1.CFU-GM
2.CFU-E
3.CFU-Mk
4.CFU-GEMM |
|
Haematopoietic Assays |
1 g
0.5 g
0.5 g
0.5 g |
Dr. R.K. Singh |
Genotoxicity assays
1. Reverse mutation assays using Salmonella typhimurium tester strains(7)
2. Reverse mutation assays using E coli tester strains (3)
3. In vitro chromosomal aberration assay
4. In vitro micronucleus assay
5. In vitro sister chromatid exchange assay
6. In vivo sister chromatid exchange assay
7. In vivo chromosomal aberration assay
8. In vivo micronucleus assay.
9. Microarray and real time based toxicity assays |
Assays |
Genotoxicity |
7 mg
3 mg
depends on ED & LD 5 mg
5 mg
5 mg
5 g
5 g
5 g
depends on requirement |
Dr. S. K. Rath |
Neurotoxicity assays
1. In vitro neurotoxicity assays
2. In vivo neurotoxicity assays
3. Rodent Models for Parkinson disease for drug screening |
Assays |
Neurotoxicity |
5 mg
Depends on ED
Depends on ED |
Dr. Sarika |
Hepatotoxicity assays
1. In vitro hepatotoxicity assays
2. In vivo hepatotoxicity assays |
Assays |
Hepatotoxicity |
1 gm |
Dr. Smrati Bhadauria |
| Models Nephrotoxicity |
Models |
Nephrotoxicity |
Depends on ED |
Dr. N. Sinha |
| Models Cardiotoxicity |
|
Cardiotoxicity |
Depends on ED |
Dr. N. Sinha |
Models for Reproduction, fertility and Teratology
1. In vivo fertility assays for both sexes
2. In vitro teratological evaluations by whole embryo culture assays
3. In vivo teratological evaluations
4. In vivo Rodent and Rabbit Models for Peri and postnatal evaluation of NCEs |
Models |
Reproduction, fertility and Teratology |
Depends on ED
10 mg
Depends on ED |
|
Models for cancer screening
1. Invadosomes biogenesis assay
2. Cell Migration assay
3. Assays to establish oxidative stress
4. Screening models for Lung, breast and hepato and prostate carcinogenesis
5. In vitro Models for establishment of pathways of anticancers |
Models |
Cancer |
1 mg
1 mg
1 mg
5 mg
5 mg |
Dr. Smrati Bhadauria
Dr. S. K. Rath
Dr. S. K. Rath |
Models for immunotoxicity
1. In vitro HIV1 RT assay
2. In vitro human cytokine profiling assays
3. In vitro model for screening immunomodulators.
4. In vivo immune toxicity |
Models |
Immunotoxicity |
5 mg
5 mg
5 mg
Depends on ED |
Dr. R. K. Tripathi |
Assays using an alternative model
1. Assay for studying effect on amyloid beta aggregation in transgenic C. elegans model of Alzheimer's disease
2. Assay for studying effect on alpha synuclein aggregation in transgenic C. elegans model of Parkinson's disease.
3. Assay for studying effect on acetylcholine content in C. elegans |
|
Toxicology |
5 mg
5 mg
5 mg |
Dr. Aamir |
| Toxicity studies for all types of Regulatory
Toxicity (single dose, sub acute and chronic exposure)
for IND purpose as per schedule Y (GOI). |
|
Toxicology |
Depends on ED 50 |
Dr. S. Sharma, Dr.
Sarika, Dr. Smrati Bhadauria,
Dr. R. K. Singh, Dr.
Poonam |
