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| CENTBUCRIDINE |
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Surgeons all over the country had been
experiencing the need of a more effective
and safer low dose local anesthetics.
The currently available local anesthetic
agents were not very quick in action
and the duration of anesthetic effect
was also not very long.
CDRI drug research programme has addressed
to this need of the country and has
come up Centbucridine. This compound
is not only safer and more effective
than the currently available local anesthetic,
lignocaine but also has features that
give it better acceptability. This drug
is a totally new chemical moiety and
has no relation whatsoever with lignocaine
Centbucridine is superior to lignocaine
in many aspects. Centbucridine has been
found to possess several desirable properties.
As compared to lignocaine, it is 4 to
5 times more potent, its onset of action
is much quicker, and the duration of
action is longer. Due to its vasoconstrictor
activity, it does not require simultaneous
administration of adrenaline. It does
not effect the cardiovascular parameters
due to its moderate antihistaminic activity
and is not likely to show skin sensitivity.
Moreover, it can be used in patients
showing hypersensitivity to lignocaine.
It had earlier been licensed to Themis
Chemicals Ltd., Mumbai which
marketed it under the brand name Centoblok.
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