|
| |
|
Dr. CHANDISHWAR NATH |
|
| |
|
... |
Chief Scientist & Head, Division of
Toxicology
CSIR-Central Drug Research Institute [C.D.R.I.]
Post Box 173
Lucknow - 226001 (INDIA)
|
| |
| Phone No. |
91- 0522-2612411-18 Ext
4259 |
| Fax No. |
91-0522-2623405 |
| Educational qualifications |
M.B.B.S., M.D. (Pharmacology) |
| E-mail |
c_nath@cdri.res.in |
| Date of Birth |
January 10, 1953 |
|
| |
| INTERNATIONAL
ASSIGNEMENTS/ VISITS |
|
•
|
U.S.A.:(i) Post-Doctoral
Associate: J.H.Miller Health Center,University of Florida,Gainesville,
(1984-1986). & (ii) Visiting Scientist: Dept.of Pharmacology,
Medical Center, University of Arizona, Tucson (1991-1992). |
• |
U.K.:To attend 9th International
Congress of Pharmacology (IUPHAR), London, 1984 |
• |
France & Switzerland:
To attend 6th European Winter Conference on Brain Research,
Avoriaz, (1986). |
• |
Thailand: (i) To attend
3rd South - East Asian and Western Pacific Regional Meeting
of Pharmacologists, Bangkok, 1982. &
(ii) To participate in 1st IBRO - Pan Asian Neuroscience's
Workshop on Neurosciences, University of Chulalongkorn,
Bangkok, 1988. |
• |
The Netherlands: INSA
Visiting Scientist, Rudolf Magnus Institute of Neurosciences,
Utrecht (2003) |
• |
Germany: Visiting Scientist,
Institute of Clinical Pharmacology & Toxicology, Charite
Medical University, Berlin (2010) |
| |
| HONOURS
/ AWARDS |
| |
• |
UVNAS PRIZE (1982) |
• |
Vice-President, Indian
Pharmacological Society (IPS), 2001 |
| • |
Prof G. Achari Oration
Award of IPS (2005) |
| • |
Dr DN Prasad Oration Award
of ICMR (2007) |
• |
Fellow: National Academy
of Medical Sciences (FAMS), Indian Pharmacological Society
(FIPS), Indian Academy of Neurosciences (FIAN) |
| |
|
| MEMBER |
| |
|
| • |
International Brain Research
Organization (I.B.R.O.) |
| • |
Advisory Committee for
IND permission, Drug Controller General of India, Ministry
of Health, Govt. of India (2009 - ) |
| • |
Research Council, Indian
Institute of Toxicological Research (IITR) (2010 -) |
• |
Member Academic Council,
JNU (2011) |
| |
| MAJOR
AREA OF RESEARCH NEUROPHARMACOLOGY for the last 33 years.
|
| |
• |
Central neurotransmitter
systems in Neruobehavioral disorders Dementia, Parkinsonism,
Drug Dependence, Depression and Aggressive behavior &
Development of Drugs for CNS disorders |
• |
Molecular mechanism in
neurotoxicity |
• |
Regulatory Toxicology
of drug development |
| |
| RESEARCH
TEAM |
| |
• |
Mr. Pradeep Kr. Kamat,
CSIR-SRF |
• |
Mr. Santosh Kr. Totawar,
CSIR-SRF |
• |
Ms. Supriya Swarnkar,
CSIR-SRF |
| |
| POST
DOCTORAL RESEARCH |
| |
| • |
J.H. Miller
Health Center, University of Florida, Gainesville, USA
(April, 1984- March, 1986) |
|
| |
| RESEARCH
EXPERIENCE |
| |
| • |
Neuropharmacology
(26 years) |
|
| |
| CURRENT
AREAS OF INTEREST |
| • |
Regulatory
Toxicology
Regulatory Pharmacology
Neuropharmacology |
|
|
| SELECTED
PUBLICATIONS |
| |
| • |
Kamat PK, Tota S, Shukla
R, Ali S, Najmi AK, Nath C, Mitochondrial dysfunction:
A crucial event in Okadaic acid (ICV) induced memory impairment
and apoptotic cell death in rat brain. Pharmacol Biochem
Behav 2011 (In press) |
• |
Saxena G, Patro IK, Nath
C, ICV STZ induced impairment in memory and neuronal mitochondrial
function: A protective role of nicotinic receptor Behavioural
Brain Research 2011; 224: 50-57. |
• |
Swarnkar S, Singh S, Sharma
s, Mathur R, Patro IK, Nath C. Rotenone induced neurotxicity
in rat brain areas: A histopathological study. Neuroscience
Letters 2011, 469: 178 -182. |
• |
Tota SK, Kamat PK, Shukla
R, Nath C Improvement of brain energy metabolism and cholinergic
functions contributes to the beneficial effects of silibinin
against streptozotocin induced memory impairment, Behavioural
Brain Research. 2011, 221; 207-215 |
• |
Agrawal R, Tyagi E, Shukla
R, Nath C. Insulin receptor signaling in rat hippocampus:
A study in STZ (ICV) induced memory deficit model
European Neuropsychopharmacology, 2011, 23, 261-273 |
• |
Swarnkar S, Singh S, Mathur
R, Patro IK, Nath C, A study to correlate rotenone induced
biochemical changes and cerebral damage in brain areas
with neuromuscular coordination in rats. Toxicology 2010;
272: 17-22. |
• |
Kamat PK.; Tota SK, Saxena
G, Shukla R, Nath C. Okadaic acid (ICV) induced memory
impairment in rats: A suitable experimental model to test
anti-dementia activity, Brain Res, 2010, 1309: 66 -74. |
• |
Saxena G, Bharti S,. Kamat
PK, Sharma S, Nath C. Melatonin alleviates memory deficits
and neuronal degeneration induced by intracerebroventricular
administration of streptozotocin in rats. Pharmacol Biochem
Behav, 2010, 94: 397-403. |
• |
Agrawal R, Tyagi E., Shukla
R., Nath C. A Study of brain insulin receptors, AChE activity
and oxidative stress in rat model of ICV STZ induced dementia
Neuropharmacology , 2009, 56: 779-787. |
• |
Swarnkar S, Tyagi E, Agrawal
R, Singh MP, Nath C. Differential anti-oxidant capacity
of rat brain areas: A study in brain homogenates, Environmental
Toxicological & Pharmacology, 2009, 27: 219-224. |
| • |
Saxena G, Singh SP, Agrawal
R, Nath C, Effect of donepezil and tacrine on oxidative
stress in intracerebral streptozotocin induced model of
dementia in mice. Eur J Pharmacol, 2008, 581: 283-289. |
• |
Saxena G, Singh SP, Pal
R, Singh S, Pratap R, Nath C, Gugulipid, an extract of
Commiphora whighitii with lipid-lowering properties, has
protective effects against Streptozotocin-induced memory
deficits in mice. Pharmacol Biochem Behav, 2007, 86: 797-805. |
• |
Das A, Dikshit M, Nath
C, Role of Molecular Isoforms of Acetylcholinesterase
in Learning and Memory Functions. Pharmacol Biochem Behav.
2005, 81: 89-99. |
• |
Das A, Rai D, Dikshit
M, Palit G, Nath C, Nature Of Stress: Differential Effects
On Brain Acetylcholinesterase Activity And Memory In Rats.
Life Sci. 2005, 77: 2299-2311. |
| • |
Role of central
histaminergic system in lorazepam withdrawal syndrome
in rats. C. Nath, and M.B. Gupta. Pharmacol Biochem Behav.
2001; 68: 777-82. |
| • |
Differential
effects of calcium channel blockers in the behavioural
despair test in mice. S.K. Srivastava, and C. Nath. Pharmacological
Research. 2000, 42: 293-7. |
| • |
Profile of
acetylcholinesterase in brain areas of male and female
rats of adult and old age. A. Das, M. Dikshit and C. Nath,
Life Sciences. 2001, 68: 1545-55. |
| • |
Effect of
dopamine agonists and antagonists on lorazepam withdrawal
syndrome in rats. C. Nath, R.C. Saxena, and M.B. Gupta.
Clin Exptl Physiol Pharmacol. 2000, 27: 167-71. |
|
| |
| Patents |
| |
| • |
US
patent # 6896901 (Grant Date: 24/05/05)
Novel use of gugulipid as cognitive enhancer, anti-hyperglycemic
and for dermal conditions
Ram Pratap, Raghvandra Pal, Satyawan Singh, Girja Shankar,
Chandishwar Nath, Hemant Kumar Singh, Deepak Raina, Arvind
Kumar Srivastava, Anil Kumar Rastogi, P.S.R.Murthy, Sudhir
Srivastava, Onkar Prasad Asthana, Narendra Singh &
Nitya Nand
|
• |
European patent # 1224938 (Grant Date: 14/12/2005):
Novel use of gugulipid as cognitive enhancer, anti-hyperglycemic
and for dermal conditions
Ram Pratap, Raghvandra Pal, Satyawan Singh, Girja Shankar,
Chandishwar Nath, Hemant Kumar Singh, Deepak Raina, Arvind
Kumar Srivastava, Anil Kumar Rastogi, P.S.R.Murthy, Sudhir
Srivastava, Onkar Prasad Asthana, Narendra Singh &
Nitya Nand |
• |
US patent # 6962945
(Grant Date: 8/11/05)
Novel N-aryloxypropanoyl-N-phenylethyl-urea Kalpana Bhandari,
Shipra Srivastava & Chandishwar Nath |
• |
European Patent # 1831172 (Grant Date:18/02/2009):
Substituted carbamic acid quinolin-6-yl esters as acetylcholinesterase
inhibitors
Neeraj Shakya, Zeeshan Fatima, Chandishwar Nath &
Anil Kumar Saxena |
• |
US Patent # 7655801
(Grant Date: 2-2-2010):
Substituted carbamic acid quinolin-6-yl esters as acetylcholinesterase
inhibitors
Neeraj Shakya, Zeeshan Fatima, Chandishwar Nath &
Anil Kumar Saxena |
• |
US Patent #7807712
(Grant Date: 05/08/2010):
Oxy Substituted chalcones as antihyperglycemic and antidyslipidemic
agents
Ram Pratap, Mavurapu Stayanaraynan, Chandishwar Nath,
Ram Raghubir, Ashok Kumar Khanna, Anju Puri, Ramesh Chander,
Priti Tiwari, Brajendra Kumar Tripathi & Arvind Kumar
Srivastava |
|
| |
| |
| |
| |
|
| |
|