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Dr. CHANDISHWAR NATH |
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Chief Scientist
Division of Toxicology
CSIR-Central Drug Research Institute [C.D.R.I.]
Sect. 10, Jankipuram Extension, Sitapur Roadi
Lucknow - 226031 (INDIA)
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| Phone No. |
91- 0522-2772450 Ext 4865 |
| Fax No. |
91-0522-2771941 |
| Educational qualifications |
M.B.B.S., M.D. (Pharmacology) |
| E-mail |
[email protected] |
| Date of Birth |
January 10, 1953 |
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| INTERNATIONAL
ASSIGNEMENTS/ VISITS |
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U.S.A.:(i) Post-Doctoral
Associate: J.H.Miller Health Center,University of Florida,Gainesville,
(1984-1986). & (ii) Visiting Scientist: Dept.of Pharmacology,
Medical Center, University of Arizona, Tucson (1991-1992). |
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U.K.:To attend 9th International
Congress of Pharmacology (IUPHAR), London, 1984 |
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France & Switzerland:
To attend 6th European Winter Conference on Brain Research,
Avoriaz, (1986). |
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Thailand: (i) To attend
3rd South - East Asian and Western Pacific Regional Meeting
of Pharmacologists, Bangkok, 1982. &
(ii) To participate in 1st IBRO - Pan Asian Neuroscience's
Workshop on Neurosciences, University of Chulalongkorn,
Bangkok, 1988. |
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The Netherlands: INSA
Visiting Scientist, Rudolf Magnus Institute of Neurosciences,
Utrecht (2003) |
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Germany: Visiting Scientist,
Institute of Clinical Pharmacology & Toxicology, Charite
Medical University, Berlin (2010) |
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| HONOURS
/ AWARDS |
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UVNAS PRIZE (1982) |
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Vice-President, Indian
Pharmacological Society (IPS), 2001 |
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Prof G. Achari Oration
Award of IPS (2005) |
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Dr DN Prasad Oration Award
of ICMR (2007) |
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Fellow:
National Academy
of Medical Sciences (FAMS)
Indian Pharmacological Society
(FIPS)
Indian Academy of Neurosciences (FIAN) |
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| MEMBER |
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International Brain Research
Organization (I.B.R.O.) |
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Advisory Committee for
IND permission, Drug Controller General of India, Ministry
of Health, Govt. of India (2009 - ) |
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Research Council, Indian
Institute of Toxicological Research (IITR) (2010 -) |
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Member Academic Council,
JNU (2011) |
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| MAJOR
AREA OF RESEARCH NEUROPHARMACOLOGY for the last 33 years.
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Central neurotransmitter
systems in Neruobehavioral disorders Dementia, Parkinsonism,
Drug Dependence, Depression and Aggressive behavior &
Development of Drugs for CNS disorders |
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Molecular mechanism in
neurotoxicity |
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Regulatory Toxicology
of drug development |
| POST DOCTORAL RESEARCH |
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J.H. Miller Health Center, University of Florida, Gainesville, USA (April, 1984- March, 1986) |
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| RESEARCH
EXPERIENCE |
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Neuropharmacology
(34 years) |
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| CURRENT
AREAS OF INTEREST |
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Regulatory
Toxicology
Regulatory Pharmacology
Neuropharmacology |
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| SELECTED
PUBLICATIONS |
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Kamat PK, Rai S, Swarnkar S, Shukla R, Ali S, Najmi AK, Nath C, Okadaic acid induced Tau phosphorylation in rat brain: Role of NMDA receptor Neuroscience 2013 DOI:10.1016/j.neuroscience.2013.01.075 (IF 3.38) |
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Swarnkar S, Goswami P, Kamat PK, Gupta S, Patro IK, Singh S, Nath C. Rotenone-induced apoptosis and role of calcium: a study on Neuro-2a cells. Arch Toxicol 2012; 86(9):1387-97. (IF 4.041) |
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Tota S, Goel R, Pachauri S, Rajasekar N, Najmi A, Hanif K, Nath C, Effect of Angiotensin II on spatial memory, cerebral blood flow, cholinergic neurotransmission and brain derived neurotrophic factor in rats, Psychopharmacology 2012, DOI: 10.1007/s00213-012-2913-8 (IF 4.077) |
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Tota, S, Hanif, K, Kamat, PK, Najmi, A, Nath C, Role of central angiotensin receptors in scopolamine induced impairment in memory, cerebral blood flow and cholinergic function.. Psychopharmacology 2012, DOI: 10.1007/s00213-012-2639-7 (IF 4.077) |
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Swarnkar S, Kamat PK, Patro IK, Singh S, Nath C. Rotenone induced neurotoxicity in rat brain areas: A study on neuronal and neuronal supportive cells Neuroscience (2012) 230:172–183 (IF 3.380) |
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Verma AK, Singh H, Satyanarayana M, Srivastava SP, Tiwari P, Singh AB, Dwivedi AK, Singh SK, Srivastava M, Nath C, Raghubir R, Srivastava AK, Pratap R, Flavone-Based Novel Antidiabetic and Antidyslipidemic Agents J Med Chem. 2012 DOI 10.1021/jm201107g (IF 5.207) |
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Tota, S., Kamat, P.K, Saxena G, Hanif K, Najmi AK, Nath, C, Central Angiotensin Converting Enzyme facilitates memory impairment in intracerebroventricular streptozotocin treated rats Behav Brain Research. 2012, 226: 317-330 (IF 3.393) |
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Agrawal R, Tyagi E, Shukla R, Nath C. Insulin receptor signaling in rat hippocampus: A study in STZ (ICV) induced memory deficit model. European Neuropsychopharmacology, 2011, 23 , 261-273 (IF 4.2) |
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Tota SK, Kamat PK, Shukla R, Nath C Improvement of brain energy metabolism and cholinergic functions contributes to the beneficial effects of silibinin against streptozotocin induced memory impairment, Behavioural Brain Research. 2011, 221; 207-215 (IF 3.393) |
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Saxena G, Patro IK, Nath C, ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor Behavioural Brain Research 2011; 224: 50-57 (IF 3.393) |
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Kamat PK, Tota S, Shukla
R, Ali S, Najmi AK, Nath C, Mitochondrial dysfunction:
A crucial event in Okadaic acid (ICV) induced memory impairment
and apoptotic cell death in rat brain. Pharmacol Biochem
Behav 2011; 100/2, 311-319 (IF 2.624). |
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Saxena G, Patro IK, Nath
C, ICV STZ induced impairment in memory and neuronal mitochondrial
function: A protective role of nicotinic receptor Behavioural
Brain Research 2011; 224: 50-57. |
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Swarnkar S, Singh S, Sharma
s, Mathur R, Patro IK, Nath C. Rotenone induced neurotxicity
in rat brain areas: A histopathological study. Neuroscience
Letters 2011, 469: 178 -182. |
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Tota SK, Kamat PK, Shukla
R, Nath C Improvement of brain energy metabolism and cholinergic
functions contributes to the beneficial effects of silibinin
against streptozotocin induced memory impairment, Behavioural
Brain Research. 2011, 221; 207-215 |
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Agrawal R, Tyagi E, Shukla
R, Nath C. Insulin receptor signaling in rat hippocampus:
A study in STZ (ICV) induced memory deficit model
European Neuropsychopharmacology, 2011, 23, 261-273 |
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Swarnkar S, Singh S, Mathur
R, Patro IK, Nath C, A study to correlate rotenone induced
biochemical changes and cerebral damage in brain areas
with neuromuscular coordination in rats. Toxicology 2010;
272: 17-22. |
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Kamat PK.; Tota SK, Saxena
G, Shukla R, Nath C. Okadaic acid (ICV) induced memory
impairment in rats: A suitable experimental model to test
anti-dementia activity, Brain Res, 2010, 1309: 66 -74. |
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Saxena G, Bharti S,. Kamat
PK, Sharma S, Nath C. Melatonin alleviates memory deficits
and neuronal degeneration induced by intracerebroventricular
administration of streptozotocin in rats. Pharmacol Biochem
Behav, 2010, 94: 397-403. |
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Agrawal R, Tyagi E., Shukla
R., Nath C. A Study of brain insulin receptors, AChE activity
and oxidative stress in rat model of ICV STZ induced dementia
Neuropharmacology , 2009, 56: 779-787. |
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Swarnkar S, Tyagi E, Agrawal
R, Singh MP, Nath C. Differential anti-oxidant capacity
of rat brain areas: A study in brain homogenates, Environmental
Toxicological & Pharmacology, 2009, 27: 219-224. |
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Saxena G, Singh SP, Agrawal
R, Nath C, Effect of donepezil and tacrine on oxidative
stress in intracerebral streptozotocin induced model of
dementia in mice. Eur J Pharmacol, 2008, 581: 283-289. |
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Saxena G, Singh SP, Pal
R, Singh S, Pratap R, Nath C, Gugulipid, an extract of
Commiphora whighitii with lipid-lowering properties, has
protective effects against Streptozotocin-induced memory
deficits in mice. Pharmacol Biochem Behav, 2007, 86: 797-805. |
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Das A, Dikshit M, Nath
C, Role of Molecular Isoforms of Acetylcholinesterase
in Learning and Memory Functions. Pharmacol Biochem Behav.
2005, 81: 89-99. |
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Das A, Rai D, Dikshit
M, Palit G, Nath C, Nature Of Stress: Differential Effects
On Brain Acetylcholinesterase Activity And Memory In Rats.
Life Sci. 2005, 77: 2299-2311. |
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Role of central
histaminergic system in lorazepam withdrawal syndrome
in rats. C. Nath, and M.B. Gupta. Pharmacol Biochem Behav.
2001; 68: 777-82. |
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Differential
effects of calcium channel blockers in the behavioural
despair test in mice. S.K. Srivastava, and C. Nath. Pharmacological
Research. 2000, 42: 293-7. |
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Profile of
acetylcholinesterase in brain areas of male and female
rats of adult and old age. A. Das, M. Dikshit and C. Nath,
Life Sciences. 2001, 68: 1545-55. |
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Effect of
dopamine agonists and antagonists on lorazepam withdrawal
syndrome in rats. C. Nath, R.C. Saxena, and M.B. Gupta.
Clin Exptl Physiol Pharmacol. 2000, 27: 167-71. |
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| Patents |
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US Patent no 8188143 (29 May, 2012)
Pharmaceutical composition useful as acetylcholinesterase inhibitors
Janaswamy Madhusudhana Rao, B. Chinaraju, P.V. Srinivas, K.S. Babu, Jhillu Singh Yadav, K. V. Raghavan, H. K. Singh, & Chandishwar Nath |
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US Patent no. 7655801 (2 February, 2010)
Substituted carbamic acid quinolin-6-yl esters as acetylcholinesterase inhibitors
Neeraj Shakya, Zeeshan Fatima, Chandishwar Nath & Anil Kumar Saxena. |
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US Patent no. 7807712 (5 October 2010)
Oxy Substituted chalcones as antihyperglycemic and antidyslipidemic agents.
Ram Pratap, Mavurapu Stayanaraynan, Chandishwar Nath, Ram Raghubir, Ashok Kumar Khanna, Anju Puri, Ramesh Chander, Priti Tiwari, Brajendra Kumar Tripathi & Arvind Kumar Srivastava |
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US Patent no: 7635779 (22 December, 2009)
Oxy substituted flavones as antihyperglycemic and antidyslipidemic agents
Ram Pratap, Mavurapu Satyanarayana, Chandishwar Nath, Ram Raghubir, Anju Puri, Ramesh Chander, Priti Tiwari, Brajendra Kumar Tripathi & Arvind Kumar Srivastava. |
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US patent no 6962945 (8 November, 2005)
Novel N-aryloxypropanoyl-N-phenylethyl-urea
Kalpana Bhandari, Shipra Srivastava & Chandishwar Nath |
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US
patent # 6896901 (Grant Date: 24/05/05)
Novel use of gugulipid as cognitive enhancer, anti-hyperglycemic
and for dermal conditions
Ram Pratap, Raghvandra Pal, Satyawan Singh, Girja Shankar,
Chandishwar Nath, Hemant Kumar Singh, Deepak Raina, Arvind
Kumar Srivastava, Anil Kumar Rastogi, P.S.R.Murthy, Sudhir
Srivastava, Onkar Prasad Asthana, Narendra Singh &
Nitya Nand
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European patent # 1224938 (Grant Date: 14/12/2005):
Novel use of gugulipid as cognitive enhancer, anti-hyperglycemic
and for dermal conditions
Ram Pratap, Raghvandra Pal, Satyawan Singh, Girja Shankar,
Chandishwar Nath, Hemant Kumar Singh, Deepak Raina, Arvind
Kumar Srivastava, Anil Kumar Rastogi, P.S.R.Murthy, Sudhir
Srivastava, Onkar Prasad Asthana, Narendra Singh &
Nitya Nand |
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US patent # 6962945
(Grant Date: 8/11/05)
Novel N-aryloxypropanoyl-N-phenylethyl-urea Kalpana Bhandari,
Shipra Srivastava & Chandishwar Nath |
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European Patent # 1831172 (Grant Date:18/02/2009):
Substituted carbamic acid quinolin-6-yl esters as acetylcholinesterase
inhibitors
Neeraj Shakya, Zeeshan Fatima, Chandishwar Nath &
Anil Kumar Saxena |
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US Patent # 7655801
(Grant Date: 2-2-2010):
Substituted carbamic acid quinolin-6-yl esters as acetylcholinesterase
inhibitors
Neeraj Shakya, Zeeshan Fatima, Chandishwar Nath &
Anil Kumar Saxena |
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US Patent #7807712
(Grant Date: 05/08/2010):
Oxy Substituted chalcones as antihyperglycemic and antidyslipidemic
agents
Ram Pratap, Mavurapu Stayanaraynan, Chandishwar Nath,
Ram Raghubir, Ashok Kumar Khanna, Anju Puri, Ramesh Chander,
Priti Tiwari, Brajendra Kumar Tripathi & Arvind Kumar
Srivastava |
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