DR DIVYA SINGH
 
.. Scientist
Endocrinology Division
Central Drug Research Institute
Lucknow-226 001
 
Educational Qualifications M.Sc. (Lucknow University), Ph.D. (JNU)
Date of Birth 21.03.1975
Phone +91-522-2612411-18 Ext. 4246
Fax +91-522-2623405
E-Mail divya_singh@cdri.res.in
 
CURRENT AREAS OF INTEREST
Identification of novel osteogenic agents and their mode of action
Role of immune system in pathophysiology of osteoporosis
SELECTED PUBLICATIONS
Abdul M Tyagi, Kamini Srivastava, Jyoti Kureel, Amit Kumar, Ashutosh Raghuvanshi, Dinesh Yadav, Rakesh Maurya, Atul Goel, Divya Singh. Premature T Cell Senescense in Ovx Mice is Inhibited by Repletion of Estrogen and Medicarpin: A Possible Mechanism for Alleviating Bone Loss. Osteoporosis Int (In press).
Abnish K. Gautam Biju Bhargavan, Abdul M Tyagi, Kamini Srivastava, Dinesh K Yadav, Manmeet Kumar, Akanksha, Jay S Mishra, Amar B Singh, Sabyasachi Sanyal, Rakesh Maurya, Lakshmi Manickavasagam, Sheelendra P Singh, Wahajuddin, Girish K Jain, Naibedya Chattopadhyay, Divya Singh. Differential Effects of Cladrin and Formononetin on Osteoblast Function, Peak Bone Mass Achievement and Bioavailability in Rats. Journal of Nutritional Biochemistry 2011 Apr; 22(4):318-27. Epub 2010 Jun 25. [Epub ahead of print].
Abdul M Tyagi, Abnish K Gautam, Amit Kumar, Kamini Srivastava, Biju Bhargavan, Ritu Trivedi, S Saravanan, Dinesk K Yadav, Nidhi Singh, Caroline Pollet, Michel Brazier, Romuald Mentaverri, Rakesh Maurya, Naibedya Chattopadhyay, Atul Goel, Divya Singh. Medicarpin Inhibits Osteoclastogenesis And Has Nonestrogenic Bone Conserving Effect in Ovariectomized Mice. Molecular and Cellular Endocrinolgy 2010 Aug 30; 325(1-2):101-9. Epub 2010 Jun 4.
Divya Singh, Sabyasachi Sanyal, Naibedya Chattopadhyay. The role of estrogen in bone growth and formation: changes at puberty. Cell Health and Cytoskel. 2010. 2011 (3) 1 – 12. DOI 10.2147/CHC.S8916.
Biju Bhargavan, Divya Singh, Abnish K Gautam, Jaysharan Mishra, Amit Kumar, Atul Goel, Manish Dixit, Rashmi Pandey, Lakshmi Manickavasagam, SD Dwivedi, Bandana Chakravarti, Girish K Jain, Ravishankar Ramachandran, Rakesh Maurya, Atul Trivedi, Naibedya Chattopadhyay, Sabyasachi Sanyal. Medicarpin, a legume phytoalexin, stimulates osteoblast differentiation and promotes peak bone mass achievement in rats: evidence for estrogen receptor ß-mediated osteogenic action of medicarpin. J Nutr Biochem. 2011 Feb 16. [Epub ahead of print].
Manmeet Kumar, Preeti Rawat, Jyoti Kureel, Anuj K Singh, Divya Singh, Rakesh Maurya. One step synthesis of 2-hydroxymethylisoflavone and their osteogenic activity. Bioorg Med Chem Lett. 2011 Mar 15; 21(6):1706-9. Epub 2011 Jan 26.
Dinesh K. Yadav, Abnish K. Gautam, Jyoti Kureel, Kamini Srivastava, Mahendra Sahai, Divya Singh, Naibedya Chattopadhyay, Rakesh Maurya. Synthetic analogues of daidzein, having more potent osteoblast stimulating effect. Bioorg Med Chem Letts 2011 Jan 21(2):677-81. Epub 2010 Dec 8.
Manmeet Kumar, Preeti Rawat, Devendra Mishra, Abnish K. Gautam, Rashmi Pandey, Divya Singh, Naibedya Chattopadhyay, Rakesh Maurya. Anti-osteoporotic constituents from Indian medicinal plants. Phytomedicine (13):993-9. Epub 2010 May 31.
Rashmi Pandey, Abnish K Gautam, Biju Bhargavan, Ritu Trivedi, Gaurav Swarnkar, Geet K Nagar, Dinesh K Yadav, Manmeet Kumar, Preeti Rawat, Lakshmi Manickavasagam, Rakesh Maurya, Atul Goel, Girish K Jain, Naibedya Chattopadhyay, Divya Singh. Total Extract and Standardized Fraction from the 1 Stem-Bark of Butea monosperma have Osteoprotective Action: Evidence for the Non-Estrogenic Osteogenic Effect of the Standardized Fraction. Menopause 2010 17(3): 602-610.
Avinash Kumar, AK Singh, Abnish K Gautam, D Chandra, Divya Singh, Bendangla Changkija B, Mahendra Pratap Singh, Ritu Trivedi. Identification of kaempferol-regulated proteins in rat calvarial osteoblasts during mineralization by proteomics. Proteomics 2010 10(9):1730-9.
Biju Bhargavan, Abnish Kumar Gautam, Divya Singh, Amit Kumar, Sumit Chaurasiya, Abdul Malik Tyagi, Dinesh Kumar Yadav, Jay Sharan Mishra, Amar Bahadur Singh, Sabyasachi Sanyal, Atul Goel, Rakesh Maurya, Naibedya Chattopadhyay. Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling. Journal of Cellular Biochemistry 2009 Oct 1; 108(2):388-99.