Dr. D. K DIKSHIT
...

Scientist F
Medicinal Chemistry Division
Central Drug Research Institute
Chatter Manzil Palace
P.O.Box No. 173
Lucknow, INDIA
 
 
Phone No. +91-0522-2212411-18-Ext 4338,
Fax No. +91-0522-2223405
E-Mail

dkdikshit[at]satyam dot net dot in & dk_dikshit[at]yahoo dot com

Educational qualifications M Sc. Ph.D.
Date of Birth 11th August 1952
 
 
CURRENT AREAS OF INTEREST
 
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 Synthetic organic / medicinal chemistry, Modified amino acids, pyroglutamate chemistry, anti-ulcer, SERMs, and anti-thrombotics
SELECTED PUBLICATIONS
 
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 Mechanistic studies on the pyridoxal phosphate enzymes: 1-aminocyclopropane -1-carboxylatedeaminase from Pseudomonas Sp. , C. Walsh, R. A. Pascal Jr, M. Johnston, R. Raines, D . K. Dikshit, A. Krantz & M. Homma, Biochemistry, 20, 7509 (1981)
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 1,2 - Addition of a-amino acid derivative to conjugated aldehydes: synthesis of vinyl serine, S. Singh, D. K. Dikshit, Tet. Lett. , 29 (25) , 3109 (1988) . T. Mathad, K. Raj and A. P. Bhaduri. Studies on the profile of Immunostimulant activities of modified iridoid glycosides, Bioorganic & Medicinal Chemistry, 6, 605-11 (1998).
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 Structure activity relationship of estrogen antagonists : A study using tri-arylbutenones, benzofuran and tri - arylfuran analogs as model for triaryl ethylenes and tri - arylpropenones, N. S. Durani, R. Jain, A Saeed, D. K. Dikshit, S. Durani & R. S. Kapil, J. Med. Chem. ,32, 1700 (1989)
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 Aldol reactions of Pyroglutamates: Chiral synthesis of 4 a (S) and 4b (R) -(Arylmethyl ) Pyroglutamates, D. K. Dikshit & S. K. Panday, J. Org. Chem. 57, 1920, (1992).
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 Titanium enolates from pyroglutamates: Exclusive formation of 4-a aldol adducts, D. K. Dikshit , S. N. Bajpai, Tet. Lett. , 36, 3231(1995)
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 Remote O,C-Dianion Chemistry of Pyroglutamates : Reaction at C-4 with electrophiles,Dinesh Kumar Dikshit and Anjana Maheswari. ,Tetrahedron Letters,40 , 4411 (1999)
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 Cycloaddition - hydrogenolysis strategy for the synthesis of 2,4-disubstituted pyroglutamats, L. N. Goswami, Stuti Srivastava, Sharad K Panday & Dinesh K Dikshit, Tetrahedron Letters, 42, 7891 (2001)
•
 A short and efficient synthesis of Preussin : Use of allyldimethylsilyl as masked hydroxyl, V. S. Singh, L. Goswami, D. K. Dikshit, Syn. Lett., 1737 (2003)