Dr. D. K DIKSHIT
...

Scientist G
& Scientist-in-Charge
Sophisticated Analytical Instuments Facility
Central Drug Research Institute
Chatter Manzil Palace
P.O.Box No. 173
Lucknow, INDIA
 
 
Phone No. +91-0522-2612411-18-Ext 4333
Fax No. +91-0522-2623405
E-Mail

 [email protected] & dk_dikshit[at]yahoo dot com

Educational qualifications M Sc. Ph.D.
Date of Birth 11th August 1952
 
 
CURRENT AREAS OF INTEREST
 
•
 Synthetic organic / medicinal chemistry, Modified amino acids, pyroglutamate chemistry, anti-ulcer, SERMs, and anti-thrombotics
SELECTED PUBLICATIONS
 
•
 Sharma Preeti, Singh Sangeeta, Siddiqui Tanveer I, Singh Vishnu S, Kundu Bijoy, Prathipati Philip, Saxena Anil K, Dikshit Dinesh K, Rastogi Leena, Dixit Chetna, Gupta MB, Patnaik GK and Dikshit Madhu. - a-Amino acid derivatives as proton pump inhibitors and potent anti-ulcer agents. (2007) - European Journal of Medicinal Chemistry 42, 386-393
•
 Srivastava, Stuti ; Goswami, Lalit N ; Dikshit, Dinesh K - Progress in the design of low molecular weight thrombin inhibitors, (2005) - Medicinal Research Reviews, Volume 25, Issue 1, 66-92.
•
 Agrawal, K.C., Srivastava, S., Singh, V.S., Dikshit, D.K., Bose, P., Sharma, P. & Kumar, N. - A new method for the synthesis of ethyl (1, 5, 6)-3-benzyl-3-azabicyclo[3.1.0.]hexane-2,4-dione-6-carboxylate: An intermediate for the trovafloxacin side chain. (2004) - Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, Volume 43, Issue 4, Pages 873-875.
•
 A short and efficient synthesis of Preussin : Use of allyldimethylsilyl as masked hydroxyl, V. S. Singh, L. Goswami, D. K. Dikshit, Syn. Lett., 1737 (2003)
•
 Cycloaddition - hydrogenolysis strategy for the synthesis of 2,4-disubstituted pyroglutamats, L. N. Goswami, Stuti Srivastava, Sharad K Panday & Dinesh K Dikshit, Tetrahedron Letters, 42, 7891 (2001)
•
 Remote O,C-Dianion Chemistry of Pyroglutamates : Reaction at C-4 with electrophiles,Dinesh Kumar Dikshit and Anjana Maheswari. ,Tetrahedron Letters,40 , 4411 (1999)
•
 1,2 - Addition of a-amino acid derivative to conjugated aldehydes: synthesis of vinyl serine, S. Singh, D. K. Dikshit, Tet. Lett. , 29 (25) , 3109 (1988) . T. Mathad, K. Raj and A. P. Bhaduri. Studies on the profile of Immunostimulant activities of modified iridoid glycosides, Bioorganic & Medicinal Chemistry, 6, 605-11 (1998).
•
 Titanium enolates from pyroglutamates: Exclusive formation of 4-a aldol adducts, D. K. Dikshit , S. N. Bajpai, Tet. Lett. , 36, 3231(1995)
•
 Aldol reactions of Pyroglutamates: Chiral synthesis of 4 a (S) and 4b (R) -(Arylmethyl ) Pyroglutamates, D. K. Dikshit & S. K. Panday, J. Org. Chem. 57, 1920, (1992).
•
 Structure activity relationship of estrogen antagonists : A study using tri-arylbutenones, benzofuran and tri - arylfuran analogs as model for triaryl ethylenes and tri - arylpropenones, N. S. Durani, R. Jain, A Saeed, D. K. Dikshit, S. Durani & R. S. Kapil, J. Med. Chem. ,32, 1700 (1989)
•
 Mechanistic studies on the pyridoxal phosphate enzymes: 1-aminocyclopropane -1-carboxylatedeaminase from Pseudomonas Sp. , C. Walsh, R. A. Pascal Jr, M. Johnston, R. Raines, D . K. Dikshit, A. Krantz & M. Homma, Biochemistry, 20, 7509 (1981)