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Electron Microscopy Unit

MAIN AREAS OF ACTIVITY

We apply a combination of high resolution microscopy approaches such as Transmission Electron Microscopy (FEI Tecnai12 TWIN), Scanning Electron Microscopy (Philips XL30) and Laser Scanning Confocal Microscopy (Carl Zeiss LSM 510 META) to address problems in drug discovery research. Mechanisms of cell death in biological systems on drug treatment including morphological and physiological effects are studied. EM experiments are planned, designed, executed and interpreted. Immuno-gold electron microscopy and confocal microscopy are used for sub-cellular localization of biological macromolecules of interest. Significant research contributions have been made in the following areas:

Parasite biology – Leishmania cytoskeleton biology; Malaria

Mechanism of cell death in human cancer cell lines and in breast cancer explants

Mode of action of anti-microbial peptides

Intra-cellular distribution of NOS isoforms in rat & human blood cells; NET formation

Mitochondrial pathology and dysfunction in gastropathy and in malarial liver damage

Evaluation of efficacy, safety and mode of action of spermicidals developed at CDRI

SCIENTISTS ASSOCIATED WITH THE PROJECT

The following scientists in this Division are associated with this project. The necessary details in respect of these scientists are enclosed. Scientists from other Divisions of the Institute are also associated with this project. They would provide this information directly to you.

•	Dr. B. Kundu	•	Dr Kalyan Mitra

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