| HIGH
THROUGHPUT SCREENING (HTS) SYSTEM |
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This facility has been
established for in-vitro biological
screening of chemical libraries using a
battery of target/ cell based assays.
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| Objectives |
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Adoption of screening
models for HTS |
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In vitro screening
of chemical libraries and natural
products in target (enzyme/receptor)
cell based assay |
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Identification of
new structural prototypes for
drug development |
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Research into development
of new target-based screens |
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| High
throughtput screening system |
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| Close-up
view of the robot |
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| Major
Equipment Acquired |
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Medium Throughput
Screening System |
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| Special
Features of Equipment |
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Robotic liquid
handler |
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Incubators with
robotic access |
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On-line bar code
reader, plate shaker, plate
washer, plate filtration |
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Plate readers
Radioactivity, luminescence,
absorbance and fluorescence |
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Sterile operations
for cell-based assays |
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| Collaborative
programs with pharmaceutical companies |
| Two collaborative
programs with major pharmaceutical industries
in the area of High throughput screening and
Combichem have been initiated. |
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| Facility
in charge : Dr. S. Sinha, TDSD Unit,
Division of Biochemistry, E-mail:
sinhas[at]lycos dot com |
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