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ASHISH ARORA |
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Dr Ashish Arora
Scientist
Molecular & Structural Biology |
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| E- Mail |
[email protected] |
| Educational Qualifications |
PhD in Biotechnology from
Panjab University (1996), MSc in Organic Chemistry from
Rajasthan University (1990) |
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| CURRENT
AREAS OF INTEREST |
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Cloning, Expression
and Purification of M. tuberculosis proteins. |
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NMR Spectroscopy
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Fluorescence
and CD spectroscopy |
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Structural
Genomics of Mycobacterium tuberculosis Proteins by NMR
Spectroscopy |
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Structural Genomics of Mycobacterium tuberculosis Proteins by
NMR Spectroscopy |
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aim is to clone, express and isotopically label important
protein drug targets of Mycobacterium tuberculosis,
for determination of their structures by NMR spectroscopy,
and use the structural information in subsequent high-throughput
screening for drug development. Currently, I am directly
supervising three graduate (Ph.D.) students. I am also
involved in planning the NMR facility for protein structure
determination at CDRI, Lucknow. We are also interested
in studying the thermodynamic stability of protein and
protein-ligand complexes using a variety of biophysical
methods. |
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| RECENT
PUBLICATIONS |
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ASHISH ARORA,
I. M. Williamson, A. G. Lee, and D. Marsh
Lipid-protein interactions with cardiac phospholamban
studied by spin-label electron spin resonance.Biochemistry
(2003), 42, 5151-8. |
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ASHISH ARORA
and L. K. Tamm, Biophysical approaches for membrane protein
structure determination. Curr. Opin. Struct. Biol. (2001)
11, 540-547. |
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L.K. Tamm,
ASHISH ARORA and J.H. Kleinschmidt , Structure and assembly
of -barrel membrane proteins. J. Biol. Chem. (2001), 276(35),
32399-402.
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ASHISH ARORA,
F. Abildgaard, J.H. Bushweller and L.K. Tamm, Structure
of the outer membrane protein A transmembrane domain by
NMR spectroscopy. Nature Struct. Biol. (2001), 8(4), 334-338. |
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ASHISH ARORA,
D. Rinehart, G. Szabo and Lukas K. Tamm, Refolded Outer
membrane protein A of Escherichia coli forms ion channels
with two conductance states in planar lipid bilayers.
J. Biol. Chem. (2000) 275(3), 1594-1600. |
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