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DR. JAWAHAR LAL |
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Scientist E-II
Pharmacokinetics & Metabolism Division
Central Drug Research Institute
Chattar Manzil, Post Box No. 173
Lucknow - 226001 (India) |
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| Fax |
91-522-2623405
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| Telephone |
(O) 91-522-2612411-18,
Ext. 4377 |
| E-Mail |
j_lal@cdri.res.in |
| Date of birth |
28 August
1957 |
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| EDUCATIONAL
QUALIFICATIONS |
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| MEMBERSHIP (LIFE) SCIENTIFIC
SOCIETIES |
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Indian Pharmaceutical Association
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Indian Pharmacological
Society |
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Society of
Biological Chemists (India) |
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Indian Chemical
Society |
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| AWARDS
AND HONOURS BEST POSTER AWARD |
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"Centchroman:
Kinetics and Disposition into Breast Milk" at 1st
Annual Conference on Chemistry, Biology and Health-Care
of Indian Society of Chemists and Biologists held during
23rd-24th March, 1996 at Central Drug Research Institute,
Lucknow (India) |
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| RESEARCH ACTIVITIES |
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Development
of new analytical procedures for monitoring investigational
and known drugs and their metabolite(s) in the biological
fluids. Preclinical and clinical pharmacokinetic studies
including absorption, metabolism and excretion studies
of investigational and known drugs. Bioequivalence study
of new formulations and drug-drug interaction studies. |
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| RESEARCH
SUPERVISION |
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Undergraduates
-14, Postgraduates - 5, Ph.D. - 1 |
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| SELECTED PUBLICATIONS |
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Lal
J, Tripathi RP and Gupta RC - Pharmacokinetics
and excretion of the novel anti-tuberculosis compound
1,2 : 5,6-di-O-isopropylidene-3-O-(phenyl cyclopropyl
methanonyl)-alpha-D-glucofuranose (S-001-14) after oral
doses in rats (2008) - Arzneimittel-Forschung-
Drug Research 58, 410-418 |
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Mehrotra N,
Lal J, Puri SK, Madhusudanan KP and Gupta
RC. - In vitro and In vivo pharmacokinetic studies of
bulaquine (analogue of primaquine), a novel antirelapse
antimalarial, in rat, rabbit and monkey-highlighting species
similarities and differences. (2007) - Biopharm
Drug Dispos 28, 209 -227 |
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Kumar, Vipul,
Lal, Jawahar, Singh, Man Mohan and Gupta,
Ram Chandra - Effect of concurrently coadministered drugs
on the pharmacokinetic/pharmacodynamic profile of centchroman,
a nonsteroidal oral contraceptive, in rats (2006)
- Contraception, 74, 165-173 |
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Kumar, V.,
Mehrotra, N., Lal, J. & Gupta, R.C.
- Pattern profiling of the herbal preparation picroliv
using liquid chromatography-tandem mass spectrometry.
(2004) - Journal of Chromatography A,
Volume 1045, Issue 1-2, 6 August 2004, Pages 145-152.
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Srivastava,
Pratima, Sharma, Preeti, Lal, Jawahar,
Dikshit, Dinesh K., Madhusudanan, Kunnath P., Gupta &
Ram, C. - Metabolism of CDRI-85/92, a new potent anti-ulcer
agent, involving cis-trans conversion. (2004)
- J. Pharma. Sc. Drug Metabolism And Drug Interactions,
Volume 20, Issue 1-2, 2004, Pages 57-76. |
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Khurana, M.,
Lal, J., Kamboj, V., Nityanand, S. &
Gupta, R.C. - Pharmacokinetic interaction of tetracycline
with centchroman in healthy female volunteers. (2003)
- Drugs R&D, 4, 293-99. |
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Lal,
J., Kumar, V., Gupta, R.C. - Pharmacokinetics
of oral and transdermal administration of a sulphur mustard
decontaminant CC-2 [N, N’-dichlorobis (2,4,6-trichlorophenyl)
urea] in rats: A preliminary study. (2003) - Indian
J. Pharmacol., 35, 297-303. |
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Mehrotra, N.,
Lal, J. & Gupta, R.C. - Analysis
and pharmacokinetics of bulaquine and its major metabolite
primaquine in rabbits using LC-UV method. (2003)
- J. Pharm. Biomed. Analysis, 32, 141-50. |
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M. Nitin, M.
Rajanikanth, J. Lal, K.P. Madhusudanan and R.C.
Gupta. A liquid chromatography-tandem mass spectrometric
assay with a novel method of quantitation for simultaneous
determination of bulaquine and its metabolite, primaquine,
in monkey plasma. J. Chromatogr. B: 2003; 793:253-63. |
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M.
Khurana, J. Lal, M. Kamboj, S. Nityanand, V.P.
Kamboj and R.C. Gupta. Uptake of centchroman by human
uterus. Clin. Drug Invest. 2002; 22:715-8. |
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M.
Khurana, J. Lal, M.M. Singh, J.K. Paliwal, V.P.
Kamboj and R.C. Gupta. Evaluation of interaction potential
of certain concurrently administered drugs with pharmacological
and pharmacokinetic profile of centchroman in rats. Contraception
2002; 66:47-56. |
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J.
Lal, S. Nityanand, O.P. Asthana and R.C. Gupta. Optimization
of contraceptive dosage regimen of centchroman. Contraception
2001;63:47-51. |
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J.
Lal, J.K. Paliwal, P.K. Grover and R.C. Gupta. Determination
of ampicillin in serum by high-performance liquid chromatography
with precolumn derivatization. J. Chromatogr. Biomed.
Appl. 1994;655:142-146 |
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