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Dr. JIAUR R. GAYEN |
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Scientist
C
Pharmacokinetics & Metabolism Division
Central Drug Research Institute
[CSIR Institute, Govt. of India]
Chattar Manzil Palace, Post Box No. 173
Lucknow - 226001, India |
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| Educational Qualifications |
Ph.D., M. Pharm., A.I.C. |
| Date of Birth |
25.12.1977 |
| E-Mail |
jr.gayen@cdri.res.in |
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| POSITION/EMPLOYMENT |
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02/2011-
present : Scientist C, Central Drug Research
Institute, Lucknow, India. |
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11/2010-01/2011:
Assistant Project Scientist Step II; University of California-San
Diego, USA. |
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02/2005-10/2010:
Postdoctoral Fellow; School of Medicine, University of
California-San Diego, USA. |
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06/2001-12/2004:
Research Fellow; Bose Institute, Calcutta, India. |
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03/2001-05/2001:
Lecturer; Himalayan Pharmacy College, Gangtok, India |
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| HONORS/AWARDS |
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Associateship
of Institution of Chemists (India) (A.I.C.) |
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Prof. Anupam Sengupta
Memorial Medal from Jadavpur University, India. |
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| RESEARCH
INTEREST |
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Metabolic
syndrome : [Hypertension, Obesity and Diabetes].
Regulation of hypertension, obesity and insulin-sensitivity
by peptides derived from chromogranin-A using animal model
and cell and molecular biology techniques. Translational
effectiveness of granin family of proteins/peptides in
Metabolic Syndrome diagnosis (Biomarker) and drug discovery.
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Pharmacokinetics
& Metabolism :
Pharmacokinetics and metabolic studies of pharmacologically/
therapeutically active compounds. |
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Phytochemistry
:
Identification, isolation of active ingredients and pharmacological/therapeutical
evaluation of medicinal plants. Exploring activity of
natural products against hypertension, obesity and diabetes. |
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| RECENT PUBLICATION
: (Citation: sum of times cited - 157;
average citation per year – 13.08) [Patent- 1; Original
article- 28; Scientific abstract- 9] |
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Lu M, Sarruf D, Talukdar
S, Sharma S, Li P, Bandyopadhyay G, Nalbandian S, Fan
W, Gayen JR, Mahata SK, Webster N, Schwartz
M, Olefsky JM; Brain Peroxisome Proliferator-Activated
Receptor Gamma Promotes Obesity and is Required for the
Full Insulin-Sensitizing Effect of Thiazolidinediones.
Nature Medicine (2011)
[in press] |
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Zhang K, Chen Y, Wen
G, Mahata M, Rao F, Fung MM, Vaingankar S, Biswas N, Gayen
JR, Friese RS, Mahata SK, Hamilton BA, O'Connor
DT; Catecholamine Storage Vesicles: Role of Core Protein
Genetic Polymorphisms in Hypertension. Curr Hypertens
Rep. (2011), 13(1): 36-45. |
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Chen Y, Rao F, Wen G,
Gayen JR, Zhang K, Vaingankar SM, Biswas
N, Mahata M, Friese RS, Fung MM, Salem RM, Nievergelt
C, Bhatnagar V, Hook VY, Ziegler MG, Mahata SK, Hamilton
BA, O’Connor DT; Naturally occurring genetic variants
in human chromogranin A (CHGA) associated with hypertension
as well as hypertensive renal disease. Cell Mol
Neurobiol (2010), 30(8): 1395-1400. |
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Gayen JR,
Zhang K, RamachandraRao S, Mahata M, Chen Y, Kim HS, Naviaux
RK, Sharma K, Mahata SK, O’Connor DT; Role of reactive
oxygen species in hyperadrenergic hypertension: Biochemical,
physiological, and pharmacological evidence from targeted
ablation of the chromogranin A (Chga) gene. Circulation
Cardiovasc Genet (2010), 3(5):
414-25. [Featured on www.MDLinx.com site. MDLinx is the
world's most up-to-date index of articles that matter
in the daily lives of physicians and other healthcare
professionals]. |
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Dev NB, Gayen
JR, O’Connor DT, Mahata SK; Chromogranin
A and the autonomic system: Decomposition of heart rate
variability and rescue by its catestatin fragment.
Endocrinology (2010), 151(6):
2760-68. |
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Vaingankar SM, Li Y, Corti
A, Biswas N, Gayen JR, O’Connor
DT, Mahata SK: Long human CHGA flanking chromosome 14
sequense required for optimal BAC transgenic rescue of
disease phenotypes in the mouse Chga knockout.
Physiol Genomics (2010), 41(1):
91-101. |
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Vaingankar SM, Li Y, Biswas
N, Gayen JR, Choksi S, Rao F, Mahata
SK, O’Connor DT; Effect of Chromogranin-A deficiency
and excess in vivo: biphasic blood pressure and catecholamine
response. J Hypertension (2010),
28(4): 817-25. |
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Friese RS,
Gayen JR, Mahapatra NR, Schmid-Schonbein
G, Mahata SK and O’Connor DT; Global metabolic consequences
of a monogenic model of hypertension: Transcriptomic detection,
pathway identification, and experimental verification
of dissociated features of the metabolic syndrome. Physiol
Genomics (2010), 40(3): 195-207. |
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Gayen JR,
Saberi M, Schenk S, Biswas N, Vaingankar S, Cheung W,
Bandyopadhyay G, O’Connor DT, Mahata SK; A novel
pathway of insulin sensitivity in chromogranin A null
mice: A crucial roll for pancreastatin in glucose homeostasis.
J Biol Chem (2009),
284(42): 28498-509. |
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Gayen JR,
Gu Y, O’Connor DT, Mahata SK; Global disturbances
in autonomic function yield cardiovascular instability
and hypertension in the chromogranin A null mouse.
Endocrinology (2009), 150(11):
5027-35. |
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Rana B, Wessel J, Mahaboubi
M, Rao F, Haeller J, Gayen JR, Eskin
E, Valle A, Das M, Mahata SK, O’Connor DT, Taylor
P; Natural variation within the neuronal nicotinic acetylcholine
receptor cluster on human chromosome 15q24: Influence
on heritable autonomic traits in the twin pairs. J
Pharmacol Exp Therapeutics (2009),
331(2): 419-28. |
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Biswas N, Rodriguez-Flores
JL, Courel M, Gayen JR, Vaingankar SM,
Mahata M, Torpey JW, Taupenot L, O'Connor DT, Mahata SK:
Cathepsin L co-localizes with chromogranin A in chromaffin
vesicles to generate active peptides. Endocrinology
(2009), 150(8): 3547-57. |
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Zhang K, Rao F, Rana
BK, Gayen JR, Calegari F, King A, Rosa
P, Huttner WB, Stridsberg M, Mahata M, Vaingankar S, Mahboubi
V, Salem RM, Rodriguez JR, Smith D, Schork NJ, Ziegler
M, Taupenot L, Mahata S and O’Connor DT: Autonomic
function in hypertension: Role of genetic variation at
the catecholamine storage vesicle protein chromogranin
B (CHGB). Circulation Cardiovasc Genet
(2009), 2: 46-56. |
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GM Portela-Gomes,
JR Gayen, L Grimelius, M Stridsberg and SK Mahata:
The importance of chromogranin A in the development and
function of endocrine pancreas. Regulatory Peptides
(2008), 151(1-3): 19-25. |
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Biswas N, Vaingankar SM,
Mahata M, Das M, Gayen JR, Taupenot L,
Torpey JW, O'Connor DT, Mahata SK: Proteolytic cleavage
of human chromogranin A containing naturally occurring
catestatin variants, differential processing at catestatin
region by plasmin. Endocrinology (2008),
Feb 149(2): 749-757. |
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JR Gayen,
S B Majee, S Das and T B Samanta: Antibacterial and toxicological
evaluation of ?eta-lactams synthesized by immobilized
?eta-lactamase-free penicillin amidase produced by Alcaligenes
sp. Ind J Exp Biol (2007),
45: 1068-1072. |
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Rao F, Wen G,
Gayen JR, Das M, Vaingankar SM, Rana BK, Mahata
M, Kennedy BP, Salem R, Stridsberg M, Abel K, Smith D,
Hamilton BA, Ziegler MG, Mahata SK and O’Connor
DT; Catecholamine Release Inhibitory Peptide Catestatin
(Chromogranin A352-372), naturally occurring amino acid
varient Gly364Ser causes profound changes in human autonomic
activity and alters risk of hypertension, Circulation
(2007), May; 115(17):2271-81. |
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NR Mahapatra, M Mahata,
S Ghosh, JR Gayen, DT O’Connor,
S Mahata: Molecular basis of neuroendocrine cell type-specific
expression of the chromogranin B gene: crucial role of
the transcription factors CREB, AP-2, Egr-1 and Sp1;
J Neurochem, (2006), 99: 119-133. |
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S Das, JR Gayen,
A Pal, K Ghosh, JPN Rosazza and TB Samanta: Purification,
substrate specificity, and N-terminal amino acid sequence
analysis of a beta-lactamase-free penicillin amidase from
Alcaligenes sp.; Applied Microbiol Biotechnol,
(2004), 65: 281-286. |
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JR Gayen,
P. Roy and T B Samanta (2004): 16S rDNA
sequence of Alcaligenes sp. (A-13); EMBL/ DDBJ/GenBank
accession number AJ716013. |
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