Dr. J Venkatesh Pratap
  Scientist -E-I
Molecular and Structural Biology Division
Central Drug Research Institute
Lucknow- 226001
U.P., India
 
Educational Qualifications M.Sc. (Madurai Kamaraj University), Ph.D. (Ind. Inst. Of Science)
Telephone +91 522 2612411 extn- 4367/4282/4425
Fax +91 522 2623405
E- Mail jvpratap[at]cdri[dot]res[dot]in
Date of Birth 27.06.1972
 
POST-DOCTORAL RESEARCH
 
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 Nov 2001 – Sep 2006 Department of Biochemistry, University of Cambridge
Cambridge, England - Structure elucidation of protein-protein complexes, understanding helical assemblies
CURRENT RESEARCH AREAS
 
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 Macromolecular crystallography, Structural approach to understanding pathogenic proteins, with emphasis on kinetoplastida
 
SELECTED PUBLICATIONS
 
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 Laughton CA, Luisi BF, Pratap JV, Calladine CR( 2008). A potential molecular switch in an alpha-helical coiled coil. Proteins 70, 25-30
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 Murzina, NV., Pei, XY.,Zhang, W., Sparkes, M.,Vicente-Garcia, J., Pratap, J.V.,McLaughlin, S.H., Luisi, B.F. & Laue, E.D. (2008) Structure Jul 16(7): 1077-85 epub PMID: 18571423
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 Frank, R.A.W., Pratap, J.V., Pei, X.Y., Perham, R.N. & Luisi, B.F. (2005). The molecular origins of specificity in the assembly of a multienzyme complex. Structure 13(8), 1119-1130.
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 Frank, R.A.W., Titman, C.M., Pratap, J.V., Luisi, B.F. & Perham, R.N. (2004). A molecular switch and proton wire synchronize the active sites in thiamine enzymes. Science, Oct 29;306:872-876.
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 Calladine, C.R., Pratap, J.V., Chandran, V., Mizuguchi, K. & Luisi, B.F. (2003). Cylindrical channels from concave helices. Science 299:661-662.
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 Pratap, J.V., Jeyaprakash, A.A., Rani, P.G., Sekar, K., Surolia, A. & Vijayan, M. (2002). Crystal structures of artocarpin, a Moraceae lectin with mannose specificity, and its complex with methyl-alpha-D-mannose: implications to the generation of carbohydrate specificity. J. Mol. Biol. 317(2):237-247.
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 Pratap, J.V., Bradbrook, G.M., Reddy, G.B., Surolia, A., Raftery, J., Helliwell, J.R. & Vijayan, M. (2001). The combination of molecular dynamics with crystallography for elucidating protein-ligand interactions: a case study involving peanut lectin complexes with T-antigen and lactose. Acta Cryst. D57:1584-1594.
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 Manoj, N., Jeyaprakash, A.A., Pratap, J.V., Komath, S.S., Kenoth, R., Swamy, M.J. & Vijayan, M. (2001). Crystallization and preliminary X-ray studies of snake gourd lectin: homology with type II ribosome-inactivating proteins. Acta Cryst. 57:912-914.
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 Pratap, J.V., Ravishankar, R. & Vijayan, M. (2000). X-ray studies on crystalline complexes involving amino acids and peptides. XXXV. Invariance and variability in amino acid aggregation in the complexes of maleic acid with L-histidine and L-lysine. Acta Cryst. B56:690-696.
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 Suresh, A.S., Rani, P.G., Pratap, J.V., Sankaranarayanan, R., Surolia, A. & Vijayan, M. (1997). Homology between jacalin and artocarpin from jackfruit (Artocarpus integrifolia) seeds. Partial sequence and preliminary crystallographic studies of artocarpin. Acta Cryst. D53:469-471.