Kalyan Mitra
 
..  
Scientist C
Electron Microscopy Unit
Central Drug Research Institute,
P.O. Box No. 173, Chattar Manzil,
Lucknow 226001
 
E-Mail  k_mitra@cdri.res.in
Educational Qualifications M.Sc. (Calcutta University), Ph.D. (Calcutta University)
Date of Birth

01.07.1975
 
RESEARCH EXPERIENCE
 
  • Ultra-structural cell biology and immuno-electron microscopy
  • Cell death pathways and signaling mechanisms involved
  • Electron microscopy of nucleic acids; partial denaturation mapping
  • Structural biology of viruses
  • Cryo-electron microscopy and three dimensional image reconstruction of protein complexes
 
POST DOCTORAL EXPERIENCE
 
Laboratory of Prof. Michael G. Rossmann at the Lucille Markey Center for Structural Biology, Purdue University, USA. (2008 - 2009)
AWARDS
 
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Recipient of best oral presentation award at the XXV th Annual Conference of the ElectronMicroscope Society of India (EMSI) held during 20th to 22nd Feb, 2002 at the Indian Institute of Technology (IIT), Bombay
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 Recipient of best photomicrograph award at the XXVII th Annual Conference of the Electron Microscope Society of India (EMSI) held during April 1-4, 2004 at the National Physical Laboratory, (CSIR), New Delhi
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 13th European Microscopy Congress (EMC 2004) scholarship at Antwerp, Belgium
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 CSIR Foreign Travel Grant to attend and present an oral paper at EMC 2004 at Antwerp, Belgium
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 Indo-US Research Fellowship for 2008 awarded by Indo-US Science & Technology Forum
 
 
SELECTED PUBLICATIONS (Journal cover page: One (Hum Reprod. 2008 Dec 16))
 
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 Jain RK, Jain A, Maikhuri JP, Sharma VL, Dwivedi AK, Kiran Kumar ST, Mitra K, Bajpai VK, Gupta G. In vitro testing of rationally designed spermicides for selectively targeting human sperm in vagina to ensure safe contraception. Hum Reprod. 2008 Mar; 24(3):590-601
Electron micrographs on cover page of journal
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 Maity P, Bindu S, Dey S, Goyal M, Alam A, Pal C, Mitra K, Bandyopadhyay U. Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: A novel role of mitochondrial aconitase oxidation. J Biol Chem. 2008 Jan 30; 284(5):3058-68
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 Dey S, Guha M, Alam A, Goyal M, Bindu S, Pal C, Maity P, Mitra K, Bandyopadhyay U. Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis. Free Radic Biol Med. 2008 Jan 15; 46(2):271-81.
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 Tammana TV, Sahasrabuddhe AA, Mitra K, Bajpai VK, Gupta CM. Actin depolymerizing factor, ADF/cofilin, is essentially required in assembly of Leishmania flagellum. Mol Microbiol. 2008 Nov; 70(4):837-52
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 Kapoor P, Sahasrabuddhe AA, Kumar A, Mitra K, Siddiqi MI, Gupta CM. An unconventional form of actin in protozoan hemoflagellate, Leishmania. J Biol Chem. 2008 Aug 15;283(33):22760-73.
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 Maity P, Bindu S, Choubey V, Alam A, Mitra K, Goyal M, Dey S, Guha M, Pal C, Bandyopadhyay U. Lansoprazole protects and heals gastric mucosa from non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy by inhibiting mitochondrial as well as Fas-mediated death pathways with concurrent induction of mucosal cell renewal. J Biol Chem. 2008 May 23;283(21):14391-401.
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 Siddique HR, Gupta SC, Mitra K, Bajpai VK, Mathur N, Murthy RC, Saxena DK, Chowdhuri DK. Adverse effect of tannery waste leachates in transgenic Drosophila melanogaster: role of ROS in modulation of Hsp70, oxidative stress and apoptosis. J Appl Toxicol. 2008 Aug;28(6):734-48.
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 Tripathi S, Mahdi AA, Nawab A, Chander R, Hasan M, Siddiqui MS, Mahdi F, Mitra K, Bajpai VK. Influence of age on aluminum induced lipid peroxidation and neurolipofuscin in frontal cortex of rat brain: A behavioral, biochemical and ultrastructural study. Brain Res. 2008 Feb 9; 1253:107-16.
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 Mitra K, Ghosh AN. Characterization of Vibrio cholerae O1 ElTor typing phage S5. Arch Virol. 2007; 152(10):1775-86.
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 Siddique HR, Gupta SC, Mitra K, Murthy RC, Saxena DK, Chowdhuri DK. Induction of biochemical stress markers and apoptosis in transgenic Drosophila melanogaster against complex chemical mixtures: role of reactive oxygen species. Chem Biol Interact. 2007 Sep 20;169(3):171-88..
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 Gupta SC, Siddique HR, Mathur N, Mishra RK, Mitra K, Saxena DK, Chowdhuri DK. Adverse effect of organophosphate compounds, dichlorvos and chlorpyrifos in the reproductive tissues of transgenic Drosophila melanogaster: 70kDa heat shock protein as a marker of cellular damage. Toxicology. 2007 Aug 16; 238(1):1-14.
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 Guha M, Maity P, Choubey V, Mitra K, Reiter RJ, Bandyopadhyay U. Melatonin inhibits free radical-mediated mitochondrial-dependent hepatocyte apoptosis and liver damage induced during malarial infection. J Pineal Res. 2007 Nov; 43(4):372-81.
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 Jain RK, Maikhuri JP, Kiran Kumar ST, Sharma VL, Dwivedi AK, Mitra K, Bajpai VK, Gupta G. Novel disulphide esters of carbothioic acid as potent, non-detergent spermicides with low toxicity to Lactobacillus and HeLa cells in vitro. Hum Reprod. 2007 Mar;22(3):708-16.
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 Ahmad A, Yadav SP, Asthana N, Mitra K, Srivastava SP, Ghosh JK. Utilization of an amphipathic leucine zipper sequence to design antibacterial peptides with simultaneous modulation of toxic activity against human red blood cells. J Biol Chem. 2006 Aug 4;281(31):22029-38.
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 Shrivastava A, Tiwari M, Sinha RA, Kumar A, Balapure AK, Bajpai VK, Sharma R, Mitra K, Tandon A, Godbole MM. Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway. J Biol Chem. 2006 Jul 14;281(28):19762-71.
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 Tiwari M, Kumar A, Sinha RA, Shrivastava A, Balapure AK, Sharma R, Bajpai VK, Mitra K, Babu S, Godbole MM. Mechanism of 4-HPR-induced apoptosis in glioma cells: evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress. Carcinogenesis. 2006 Oct;27(10):2047-58.
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 Choubey V, Guha M, Maity P, Kumar S, Raghunandan R, Maulik PR, Mitra K, Halder UC, Bandyopadhyay U. Molecular characterization and localization of Plasmodium falciparum choline kinase. Biochim Biophys Acta. 2006 Jul;1760(7):1027-38.