Dr. KAMLAKAR AVASTHI
 

..

 Scientist
Medicinal and Process Chemistry Division
Central Drug Research Institute
Lucknow-226001
 India
 
Educational Qualifications M.Sc. Ph.D.
Date of Birth Nov. 24, 1952
E- mail kavch[at]hotmail dot com , kavasthi[at]rediffmail dot com
Phone No. +91-0522-2612411-18-Ext 4453
Fax No. +91-0522-2623405
 
POST DOCTORAL EXPERIENCE
•
 1976-1985

 Indian Institute of Technology, Kanpur (with Prof. D. Devaprabhakara); Hokkaido University, Sapporo, JAPAN (with Prof. Akira Suzuki); University of Alberta, Edmonton, CANADA (with Prof. E. E. Knaus); University of Wisconsin, Milwaukee, Wis. USA (with Prof. J. M. Cook); Cornell University, Ithaca, N. Y., USA (with Prof. D. B. Collum); Case Western Reserve University, Cleveland, Ohio, USA (with Prof. R. G. Salomon).
 
RESEARCH EXPERIENCE
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Synthetic Organic Chemistry (33 years), Medicinal Chemistry (20 years),
Supramolecular Chemistry (10 years).
 
CURRENT AREAS OF INTEREST
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 Molecular recognition and conformational analysis. Supramolecular chemistry, Design and Synthesis of bio-active molecules, CNS/CVS active agents, Anti-allergic and Anti-inflammatory agents.
SELECTED PUBLICATIONS
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 Fine tuning of folded conformation by change of substituents: 1H NMR and crystallographic evidence for folded conformation due to arene interactions in pyrazolo[3,4-d]pyrimidine core based propylene linker compounds, K. Avasthi, S. Aswal, R. Kumar, U. Yadav, D. S. Rawat, P. R. Maulik, J. Mol. Structure, 2005, 750, 191-197.
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 A stacked pyrazolo[3,4-d]pyrimidine-based flexible molecule: the effect on stacking of a bulky isopropyl group in comparison with a methyl/ethyl group, K. Avasthi, S. M. Farooq, D. S. Rawat, A. Sharon, P. R. Maulik, Acta Crystallogr. 2003, C59, o523-o524.
•
 4,6-Bis(methylsulfanyl)-1-(4-phenoxybutyl)-1H- pyrazolo[3,4-d]pyrimidine, K. Avasthi, C. Bal, A. Sharon, P. R. Maulik, Acta Crystallogr. 2003, C59, o494-o495
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 Unusual molecular conformation in dissymmetric propylene-linker compounds containing pyrazolo[3,4-d]pyrimidinyl and phthalimido moieties, K. Avasthi, D. Bhagat, C. Bal, A. Sharon, U. Yadav, P. R. Maulik, Acta Crystallogr. 2003, C59, o409-o412.
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 Intermolecular stacking in pyrazolo[3,4-d]pyrimidine-based penta-methylene linked flexible molecules. K. Avasthi, S. M. Farooq, A. K. Tewari, A. Sharon, P. R. Maulik, Acta Crystallogr. 2003, C59, o42-o45.
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 Disappearance of inter- and intramolecular stacking due to one- atom addition in “propylene linker” in a pyrazolo[3,4-d]pyrimidine-based flexible molecule, K. Avasthi, S. M. Farooq, A. Sharon, P. R. Maulik, Acta Crystallogr. 2002, E58, o940-o941.
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 A stacked pyrazolo[3,4-d]pyrimidine-based flexible molecule: the effect of a bulky benzyl group on intermolecular stacking in comparison with methyl and ethyl groups, K. Avasthi, A. Tewari, D. S. Rawat, A. Sharon, P. R. Maulik, Acta Crystallogr. 2002, C58, o494-o495.
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 A dimeric layered structure of a 4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine compound, K. Avasthi, D. S. Rawat, S. Sarkhel, P. R. Maulik, Acta Crystallogr. 2002, C58, o325-o327.
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 Isomeric pyrazolo[3,4-d]pyrimidine based molecules: disappearance of dimerization due to interchanged substitution, K. Avasthi, D. S. Rawat, T. Chandra, A. Sharon, P. R. Maulik, Acta Crystallogr. 2002, C58, o311-o313.
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 1,3-Bis(8-chlorotheophyllin-7-yl)propane: a molecule with no intramolecular stacking, P. R. Maulik, K. Avasthi, S. Sarkhel, A. Sharon, D. S. Rawat, C. Bal, Acta Crystallogr. 2001, E57, o1163-o1165.
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 1H NMR and X-ray crystallographic analysis of 1,2-bis(4,6-diethylthio-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethane and its “propylene linker”-analog: molecular recognition versus crystal engineering, K. Avasthi, D. S. Rawat, P. R. Maulik, S. Sarkhel, C. K. Broder, J. A. K. Howard, Tetrahedron Lett. 2001, 42, 7115-7117.
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 A stacked pyrazolo[3,4-d]pyrimidine-based flexible molecule: Effect of ethyl group in comparison to methyl group on stacking, K. Avasthi, S. Aswal, P. R. Maulik, Acta Crystallogr. 2001, C57, 1324-1325.