BIODATA of Dr Kamlakar Avasthi ::: Welcome to CDRI

Dr. KAMLAKAR AVASTHI

Scientist G
Medicinal and Process Chemistry Division
Central Drug Research Institute
Lucknow-226001
India

Educational Qualifications	M.Sc. Ph.D.
Date of Birth	Nov. 24, 1952
E- mail	[email protected]
Phone No.	+91-0522-2612411-18-Ext 4453
Fax No.	+91-0522-2623405

POST DOCTORAL EXPERIENCE

•

1976-1985

Indian Institute of Technology, Kanpur (with Prof. D. Devaprabhakara); Hokkaido University, Sapporo, JAPAN (with Prof. Akira Suzuki); University of Alberta, Edmonton, CANADA (with Prof. E. E. Knaus); University of Wisconsin, Milwaukee, Wis. USA (with Prof. J. M. Cook); Cornell University, Ithaca, N. Y., USA (with Prof. D. B. Collum); Case Western Reserve University, Cleveland, Ohio, USA (with Prof. R. G. Salomon).

RESEARCH EXPERIENCE

•	Synthetic Organic Chemistry (33 years), Medicinal Chemistry (20 years), Supramolecular Chemistry (10 years).

CURRENT AREAS OF INTEREST

•	Molecular recognition and conformational analysis. Supramolecular chemistry. Development of new flexible models based on pyrazolo[3,4-d]pyrimidine for better understanding of arene (pi-pi) interactions. Design and Synthesis of bio-active molecules, CNS/CVS active agents.

SELECTED PUBLICATIONS

•	K. Avasthi, S. M Farooq, R. Raghunandan, P. R. Maulik,- Studies on arene interactions in flexible pyrazolo[3,4-d]pyrimidine core based symmetrical ‘propylene/Leonard linker’ models: X-ray crystallographic evidence for disappearance of intramolecular stacking due to presence of chloro- or cyano- groups in place of methylsulfanyl or alkoxy substituents ( 2009) J. Mol. Structure, 927, 27-36.
•	Avasthi K, Aswal S, Farooq SM, Raghunandan R and Maulik PR - Unusual effect of bulky isopropyl group on robustness of the U-motif in pyrazolo[3,4-d]pyrimidine core based ‘Leonard linker’ compounds in comparison to methyl/ethyl group: A 1H NMR and X-ray crystallographic study (2008) - J. Mol. Structure 888, 327-336
•	Avasthi Kamlakar, Farooq Sheikh M, Bal Chandralata, Kumar Rishi, Tewari Ashish K and Maulik Prakas R - Design and synthesis of pyrazolo [3,4-d]pyrimidine and triazolo[4,5-d]pyrimidine based dissymmetrical ‘Leonard linker’ compounds: 1H NMR and crystallographic evidence for folded conformation due to arene interactions. (2007) - Journal of Molecular Structure 842, 100-108
•	Avasthi Kamlakar, Farooq Sheikh M, Aswal Sangeeta, Raghunandan Resmi and Maulik Prakas R - 1H NMR and crystallographic evidence for tolerance of bulky electron withdrawing methanesulfonyl group on robustness of the U-motif in pyrazolo [3,4-d]pyrimidine core based ‘Leonard linker’ compounds and formation of plus (+) motif. (2007) - Journal of Molecular Structure 827, 88-94
•	Avasthi, Kamlakar, Farooq, Sheikh M., Raghunandan, Resmi and Maulik, Prakas R. - Design and synthesis of pyrazolo[3,4-d]pyrimidine core based dissymmetrical 'Leonard linker' compounds: 1H NMR and crystallographic evidence for folded conformation due to arene interactions (2006) - Journal of Molecular Structure, 785, 106-113.
•	Fine tuning of folded conformation by change of substituents: 1H NMR and crystallographic evidence for folded conformation due to arene interactions in pyrazolo[3,4-d]pyrimidine core based propylene linker compounds, K. Avasthi, S. Aswal, R. Kumar, U. Yadav, D. S. Rawat, P. R. Maulik, J. Mol. Structure, 2005, 750, 191-197.
•	A stacked pyrazolo[3,4-d]pyrimidine-based flexible molecule: the effect on stacking of a bulky isopropyl group in comparison with a methyl/ethyl group, K. Avasthi, S. M. Farooq, D. S. Rawat, A. Sharon, P. R. Maulik, Acta Crystallogr. 2003, C59, o523-o524.
•	4,6-Bis(methylsulfanyl)-1-(4-phenoxybutyl)-1H- pyrazolo[3,4-d]pyrimidine, K. Avasthi, C. Bal, A. Sharon, P. R. Maulik, Acta Crystallogr. 2003, C59, o494-o495
•	Unusual molecular conformation in dissymmetric propylene-linker compounds containing pyrazolo[3,4-d]pyrimidinyl and phthalimido moieties, K. Avasthi, D. Bhagat, C. Bal, A. Sharon, U. Yadav, P. R. Maulik, Acta Crystallogr. 2003, C59, o409-o412.
•	Intermolecular stacking in pyrazolo[3,4-d]pyrimidine-based penta-methylene linked flexible molecules. K. Avasthi, S. M. Farooq, A. K. Tewari, A. Sharon, P. R. Maulik, Acta Crystallogr. 2003, C59, o42-o45.
•	Disappearance of inter- and intramolecular stacking due to one- atom addition in “propylene linker” in a pyrazolo[3,4-d]pyrimidine-based flexible molecule, K. Avasthi, S. M. Farooq, A. Sharon, P. R. Maulik, Acta Crystallogr. 2002, E58, o940-o941.
•	A stacked pyrazolo[3,4-d]pyrimidine-based flexible molecule: the effect of a bulky benzyl group on intermolecular stacking in comparison with methyl and ethyl groups, K. Avasthi, A. Tewari, D. S. Rawat, A. Sharon, P. R. Maulik, Acta Crystallogr. 2002, C58, o494-o495.
•	A dimeric layered structure of a 4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine compound, K. Avasthi, D. S. Rawat, S. Sarkhel, P. R. Maulik, Acta Crystallogr. 2002, C58, o325-o327.
•	Isomeric pyrazolo[3,4-d]pyrimidine based molecules: disappearance of dimerization due to interchanged substitution, K. Avasthi, D. S. Rawat, T. Chandra, A. Sharon, P. R. Maulik, Acta Crystallogr. 2002, C58, o311-o313.
•	1,3-Bis(8-chlorotheophyllin-7-yl)propane: a molecule with no intramolecular stacking, P. R. Maulik, K. Avasthi, S. Sarkhel, A. Sharon, D. S. Rawat, C. Bal, Acta Crystallogr. 2001, E57, o1163-o1165.
•	1H NMR and X-ray crystallographic analysis of 1,2-bis(4,6-diethylthio-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethane and its “propylene linker”-analog: molecular recognition versus crystal engineering, K. Avasthi, D. S. Rawat, P. R. Maulik, S. Sarkhel, C. K. Broder, J. A. K. Howard, Tetrahedron Lett. 2001, 42, 7115-7117.
•	A stacked pyrazolo[3,4-d]pyrimidine-based flexible molecule: Effect of ethyl group in comparison to methyl group on stacking, K. Avasthi, S. Aswal, P. R. Maulik, Acta Crystallogr. 2001, C57, 1324-1325.