DR. (Mrs) KUMKUM SRIVASTAVA ( NEE TYAGI)
 
 

Scientist E- II
Division of Parasitology
Central Drug Research Institute,
Lucknow 226001, INDIA

 
Educational Qualifications M.Sc. Ph.D.
E-Mail kumkum_srivastava@cdri.res.in
Date of Birth 11th October 1957
 
POST DOCTORAL RESEARCH
 
•
 Central Drug Research Institute, Lucknow
(Aug. 1986- May 2000).
 
RESEARCH EXPERIENCE
 
•
 25 years experience ( Filariasis and Malaria )
 
AREAS OF RESEARCH
 
•
 Drug Development, Model Development and Host-Parasite Relationship
 
CURRENT AREAS OF INTEREST
 
•
 In vitro Culture of Plasmodium falciparum : Development of New Antimalarial Agents- Lead Identification and Model Development
SELECT PUBLICATIONS
 
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 Gupta Leena, Srivastava Kumkum, Puri SK, Singh Shubhra and Chauhan Prem MS - Synthesis of 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted phenyl)-2,3,4,9-tetrahydro-1H-ß-carbolines as a new class of antimalarial agents (2008) - Bioorganic and Medicinal Chemistry Letters 18, 6530-6533
•
 Kumar Ashok, Srivastava Kumkum, Puri SK, and Chauhan Prem MS - Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agents (2008) - Bioorganic and Medicinal Chemistry Letters 18, 6530-6533
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 Kumar S, Guha M, Choubey V, Maity P, Srivastava K, Puri SK and Bandyopadhyay U - Bilirubin inhibits Plasmodium falciparum growth through the generation of reactive oxygen species (2008) - Free Radical Biology & Medicine 44, 602-13
•
 Kumar Satish, Misra Namita, Raj K, Srivastava Kumkum and Puri SK - Novel class of hybrid natural products derived from lupeol as antimalarial agents (2008) - Nat. Prod. Res.22, 305-19
•
 Parai KM, Panda G, Srivastava K and SK Puri - Design, synthesis and antimalarial activity of benzene and isoquinoline sulfonamide derivatives (2008) - Bioorganic and Medicinal Chemistry Letters 18, 776-781
•
 Solomon VR, Haq W, Smilkstein M, Srivastava K, Rajakumar S, Puri SK and Katti SB - Synthesis and antimalarial activity of novel side chain modified antimalarial agents derived from 4-aminoquinoline (2008) - Med. Chem. 4, 446-56
•
 Bajpai P, Srivastava K, Shakya S, Saxena PN and Misra-Bhattacharya S - Improvement in the efficacy of existing combination of antifilarials by inclusion of tetracycline in rodent model of brugian filariasis. (2007) - Current Science 92, 655-658
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 Choubey Vinay, Maity Pallab, Guha Mithu, Kumar Sanjay, Srivastava Kumkum, Puri Sunil Kumar and Bandyopadhyay Uday - Inhibition of Plasmodium falciparum choline kinase by hexadecyltrimethylammonium bromide: a possible antimalarial mechanism. (2007) - Antimicrobial Agents and Chemotherapy 51, 696-706
•
 Guha Mithu, Choubey Vinay, Maity Pallab, Kumar Sanjay, Srivastava Kumkum, Puri Sunil K and Bandyopadhyay Uday. - Overexpression, purification and localization of apoptosis related protein from Plasmodium falciparum. (2007) - Protein Expression and Purification 52, 363-372
•
 Narender T, Reddy KP, Shweta, Srivastava K, Mishra DK and Puri SK. - Total synthesis of Munchiwarin, a triprenylated chalcone from Crotalaria medicagenia. (2007) - Org Lett 9, 5369-5372
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 Solomon V Raja, Haq W, Srivastava Kumkum, Puri Sunil K and Katti SB - Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives (2007) - Journal of Medicinal Chemistry 50, 394-398
•
 Srivastava K, Singh S, Singh P and Puri SK - In vitro cultivation of Plasmodium falciparum: Studies with modified medium supplemented with ALBUMAX II and various animal sera. (2007) - Experimental Parasitology 116, 171-174
•
 Bishnoi, A, Srivastava K & Joshi M N. - Synthesis, characterization and in vitro anti-JEV activity of N-[p-{3'-(2'-aryl-4'-oxo-1',3'-thiazolyl) diphenyl]-7-hydroxy-4-methyl-2-oxoquinolines (2006) - Indian J Chemistry :45B, 1961-4.
•
 Agarwal Anu, Srivastava K., Puri S.K., Sinha S., Chauhan P.M.S. - Solid support synthesis of 6-aryl-2-substituted pyrimidin-4-yl phenols as anti-infective agents (2005) - Bioorganic & Medicinal Chemistry Letters, 15, 4923-4926
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 Response of Brugia malayi - Indian Leaf Monkey (Presbytis entellus), a non-human primate Model of Filariasis, to diethylcarbamazine, ivermectin and CDRI Compond, 82-437. P K Murthy, K Srivastava and P S R Murthy. Current Science 86: 432-39, (2004)
•
 Tetracycline, a tool for transmission blocking of Brugia malayi in Mastomys coucha.
K. Srivastava and Shailja Misra- Bhattacharya Current Science 85: 588-589 (2003)
•

Brugia malayi: Establishment in inbred and out bred strains of mice. Ruma Gupta, K.Tyagi, S.K. Jain & Shailja Misra - Bhattacharya. Experimental Parasitology 103: 57-60 (2003).
•
 Longitudinal humoral immune responses of Indian leaf monkey (Prestytis entellus) to Brugia malayi infection. P.K.Murthy, K.Tyagi, R. P.Ghosh , P.S.R..murthy, & R.K. Chatterjee. Parasitology 199: 53 -60 (1999)
•
 Experimental transmission of nocturnally periodic Wuchereria bancrofti to Indian leaf monkey (Presbytis entellus). Shailja Misra, K.Tyagi & R.K..Chatterjee. Experimental Parasitology 86: 155-157 (1997)