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  LEISHMANIASIS
 

OBJECTIVE

Visceral leishmaniasis caused by Leishmania donovani is a major cause for morbidity and mortality in North Eastern Region of the country. The problem is compounded by the availability of toxic drugs and the pathogen becoming resistant to these drugs.

The programme therefore envisages screening of synthetic compounds as well as extracts from plants and marine sources for antileishmanial activity development of diagnostic kit of high specificity and sensitivity, studies on molecular mechanisms of virulence and drug resistance, and search for newer specific biochemical and molecular targets for designing safe and effective antileishmanial compounds.
MAIN AREA OF RESEARCH
Development of new antileishmanial agents
•
 Formation of transgenic promastigotes bearing fluorescence or luminescence based reporter system for quick and reliable screening of large number of compounds
•
 Primary in vitro screening
•
 Confirmation by in vivo screening
•
 Follow up in secondary model
 
Biochemical and Molecular biology studies
•
 Microfilament systems
•
 Dynamics of phospholipids in plasma membrane
•
 Mechanism of drug resistance
•
 Cloning and expression of target enzymes
•
 Application of Microarray in search of genes related to drug resistance and transformation of the parasite.
 
SCIENTISTS ASSOCIATED WITH THE PROJECT
•
 Dr C M Gupta
•
 Dr. Mrs. Anuradha Dube Nee Misra
•
 Dr. Mrs. Aruna Kapil
•
 Dr. Mrs. Uma Roy
•
 Dr. Miss Neeloo Singh
•
 Dr. Miss Suman Gupta
•
 Dr. Neena Goyal
•
 Amogh Sahastrabuddhe
       
 
 
 
 
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