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Madhu Dikshit |
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Scientist
Division of Pharmacology
Central Drug Research Institute, Lucknow 226 00 |
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| Educational qualifications |
M.Sc., Ph.D. |
| E-mail |
madhudikshit[at]yahoo dot com |
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| CURRENT
AREAS OF INTEREST |
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Role of NO
in the physiological as well as pathological conditions
(thrombosis, ischemia, hypertension, and neurodegeneration) |
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Molecular
mechanisms involved in the regulation of NADPH-oxidase
and
NOS activity in the neutrophils |
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Peripheral
markers in the CNS disorder |
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Functional
flow cytometry |
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| RESEARCH EXPERIENCE |
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Biochemical
Pharmacology |
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| SELECTED
PUBLICATIONS |
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Sharma P,
Raghavan SAV and Dikshit M: Role of ascorbate in the regulation
of nitric oxide generation by polymorphonuclear leukocytes.
Biochem Biophys Res Commun (in press), 2003. |
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Sharma P,
Barthwal MK and Dikshit M: NO Synthesis and its regulation
in the arachidonic acid stimulated rat polymorphonuclear
leukocytes. Nitric Oxide Biol. Chem., 7, 119-126, 2002. |
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Singh MP,
Sinha S, Raghavan SAV and Dikshit M: Inhibition of platelet
aggregation by rat globin. Thrombosis Research 107, 201-207,
2002. |
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Raghavan
SAV and Dikshit M: Augmented relaxation to L-citrulline
in lipopolysaccharide treated rat aorta: possible role
of L-citrulline in endotoxaemia. Eur J Pharmacol. 431,
61-69, 2001. |
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Sethi S,
Singh MP and Dikshit M: Nitric oxide mediated augmentation
of polymorphonuclear free radical generation following
hypoxia-reoxygenation. Blood 93, 333-340, 1999. |
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Barthwal
MK, Srivastava N, Shukla R, Nag D, Seth PK, Srimal RC
and Dikshit M: Polymorphonuclear leukocyte nitrite content
and antioxidant enzymes in Parkinson's disease patients.
Acta Neurol Scand. 100, 300-304, 1999. |
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Seth P, Kumari
R, Dikshit M and Srimal RC: Modulation of rat polymorphonuclear
leukocyte response by nitric oxide and arginine. Blood
84, 2741-2748, 1994. |
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Dikshit M,
Kumari R and Srimal RC: Pulmonary thromboembolism induced
alterations in the nitric oxide release from the rat neutrophils.
J Pharmacol Exp Therap 265, 1369-1373, 1993. |
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| PATENTS FILED / ACCEPTED |
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A process
for the preparation of novel 1-arylalkyl-5-oxo-proline
carboxamides useful as thrombin inhibitors. Dinesh Kumar
Dikshit, Madhu Dikshit, Prashant Sharma, Stuti Srivastava,
(Product patent [NF/492/01] and Process patent [NF/486/01]
Filed for Indian Patent on 29.11.2001) |
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WGI/75K Novel
herbal composition for the treatment of Gastric Ulcer.
JM Rao, U Sampath Kumar, BS Sastry, JS Yadav, KV Raghavan,
G Palit, M Dikshit, D Rai, PM Varier, TS Muraleedharan,
K Muraleedharan [filed for the international patent in
USA and European countries]. |
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