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| DR.
NAIBEDYA CHATTOPADHYAY |
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Scientist F & Deputy
Director
Scientist-in-Charge
Endocrinology Division
Central Drug Research Institute
Lucknow - 226 001, India |
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| POST-DOCTORAL
POSITIONS |
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1994 -1998
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Endocrine-Hypertension
Division, Brigham and Women’s Hospital, Harvard
Medical School, Boston, MA |
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11/1998- 06/2003 |
Instructor in Medicine,
Harvard Medical School, Endocrine-Hypertension Division,
Brigham and Women’s Hospital, Boston, MA. |
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07/2003-04/2006 |
Assistant Professor of
Medicine, Harvard Medical School, Division of Endocrinology,
Diabetes & Hypertension, Brigham and Women’s
Hospital, Boston, MA. |
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| CURRENT
AREAS OF INTEREST |
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Anabolic action(s)
of calcium-sensing receptor in osteoblasts. |
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Chemokine
regulation of bone cell function |
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Calcium-sensing receptor
in oligodendrocyte function and myelinogenesis |
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Calcium-sensing receptor
regulation of GnRH neuron migration |
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Calcium-sensing receptor
mediated regulation of PTHrP secretion. |
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| SELECTED
RECENT PUBLICATIONS |
Total no. of publications: 83 [Research
articles – 64, invited reviews – 11, proceedings
of meeting – 4, book chapters – 3, book(s) edited
– 1]
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Chattopadhyay
N. Effects of calcium-sensing receptor on the
secretion of parathyroid hormone-related peptide and its
impact on humoral hypercalcemia of malignancy. Am
J Physiol Endocrinol Metab. 290: E761-770, 2006.
(Invited review) |
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Mentaverri
R, Yano S, Chattopadhyay N, Cournarie
F, Brown EM. The calcium-sensing receptor is directly
involved in both osteoclast differentiation and apoptosis.
FASEB J (Epub. Oct 31), 2006. |
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Chattopadhyay
N, Jeong K-H, Yano S, Huang S, Ren X, Terwilliger E, Kaiser
UB, Vassilev PM, Pollak MR, Brown EM. Calcium receptor
stimulates chemotaxis and secretion of MCP-1 in GnRH neurons
in vitro: Potential impact on reduced GnRH neuron population
in CaR-null mice. Am J Physiol Endocrinol Metab (Epub.
Sep 26) 2006. |
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Pang JL,
Ricupero D, Huang S, Fatma N, Singh DP, Romero JR, Chattopadhyay
N. Differential activity of kaempferol and quercetin
in attenuating tumor necrosis factor receptor family
signaling in bone cells. Biochem Pharmacol 71:818-826,
2006. |
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Yano S, Mentaverri R,
Kanuparthi D, Bandyopadhyay S, Rivera A, Brown EM, Chattopadhyay
N. Functional expression of ?-chemokine (C-C) receptors
in osteoblasts: role of RANTES in osteoblasts and regulation
of its secretion by osteoblasts and osteoclasts. Endocrinology
146:2324-2335, 2005. |
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Chattopadhyay
N, Yano S, Tfelt-Hansen J, Rooney P, Kanuparthi D, Bandyopadhyay
S, Ren X, Terwilliger E, Brown EM. Mitogenic action of
calcium-sensing receptor on rat calvarial osteoblasts.
Endocrinology 145:3451-3462, 2004. |
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Tfelt-Hansen
J, Yano S, Bandyopadhyay S, Carroll R, Brown EM, Chattopadhyay
N. Expression of pituitary tumor transforming gene (PTTG)
and its binding protein in human astrocytes and astrocytoma
cells: function and regulation of PTTG in U87 astrocytoma
cells. Endocrinology 145:4222-31, 2004. |
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Tfelt-Hansen
J, Schwarz P, Terwilliger EF, Brown EM, Chattopadhyay
N. Calcium-sensing receptor induces mRNA of human securin,
pituitary tumor transforming gene, in rat testicular cancer.
Endocrinology 144: 5188-5193, 2003. |
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Nearing J, Betka M, Quinn
S, Hentschel H, Elger M, Baum M, Bai M, Chattopadyhay
N, Brown EM, Hebert SC, Harris HW. Polyvalent cation receptor
proteins (CaRs) are salinity sensors in fish. Proc Natl
Acad Sci USA 99:9231-9236, 2002. |
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Chattopadhyay N, Bai M,
Brown EM. Extracellular calcium-sensing receptor. In Wiley
Encyclopedia of Molecular Medicine; Creighton TE (Ed)
John Wiley & Sons, Inc. pp. 425-428, 2002. (Chapter) |
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Hjalm G, MacLeod RJ, Kifor
O, Chattopadhyay N, Brown EM. Filamin-1 binds to the carboxy-terminal
tail of the calcium-sensing receptor (CaR), an interaction
that participates in CaR-mediated activation of mitogen-activated
protein kinase (MAPK). J Biol Chem 276: 34880-34887, 2001. |
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Brown EM, Conigrave A,
Chattopadhyay N. Receptors and signaling for calcium ions.
In The Parathyroids: Basic and clinical concepts (2nd
edition); Bilezikian JP, Marcus R, Levine MA (Eds.). Academic
Publishers p.127-142, 2001. (Chapter) |
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