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| DR.
NAIBEDYA CHATTOPADHYAY |
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Scientist F & Deputy
Director
Scientist-in-Charge
Endocrinology Division
Central Drug Research Institute
Lucknow - 226 001, India |
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| Educational Qualifications |
M.Sc ( Presidency College, Calcutta)
, Ph.D. ( SGPGI ) |
| Date of Birth |
25.05.1965 |
| Phone |
091-522-2613894 (O) |
| Fax |
091-522-2623405, 2623938
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| E-Mail |
n_chattopadhyay@cdri.res.in |
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| POST-DOCTORAL
POSITIONS |
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1994 -1998
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Endocrine-Hypertension
Division, Brigham and Women’s Hospital, Harvard
Medical School, Boston, MA |
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11/1998- 06/2003 |
Instructor in Medicine,
Harvard Medical School, Endocrine-Hypertension Division,
Brigham and Women’s Hospital, Boston, MA. |
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07/2003-04/2006 |
Assistant Professor of
Medicine, Harvard Medical School, Division of Endocrinology,
Diabetes & Hypertension, Brigham and Women’s
Hospital, Boston, MA. |
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| CURRENT
AREAS OF INTEREST |
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Bone anabolic
agents |
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New chemical
entities against breast cancer |
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| PUBLICATIONS
AT A GLANCE |
Total no. of publications: –
115 [Research articles – 85, Invited reviews - 22,
Proceedings of meetings – 4, Boos & Monographs
– 4
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Citation Analysis- Sum of times
cited – 3,021, average citation per
item- 35.13, average citation per year-
188.81, h-index for original articles
- 34
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| LIST
OF PUBLICATIONS IN LAST 2 YEARS |
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Sharan K,
Swarnkar G, Siddiqui JA, Khan K, Kumari R, Rawat P, Maurya
R, Sanyal S, Chattopadhyay N.
A novel quercetin analog from a medicinal plant promotes
peak bone mass achievement, bone healing after injury
and exerts anabolic effect on osteoporotic bone: the role
of aryl hydrocarbon receptor as a mediator of osteogenic
action. J Bone Miner Res 26:2096-2011, 2011. |
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Dhar Dwivedi SK, Singh
N, Kumari S, Mishra JS, Tripathi S, Banerjee P, Shah P,
Kukshal V, Tyagi AM, Gaikwad AN, Chaturvedi RK, Mishra
DP, Trivedi AK, Sanyal S, Chattopadhyay N,
Ramachandran R, Siddiqui MI, Bandyopadhyay A, Arora A,
Lundåsen T, Anak SP, Moore DD, Sanyal S. Bile acid
receptor agonist GW4064 regulates PPAR??coactivator-1??expression
through estrogen receptor-related receptor ?. Mol
Endocrinol (in press), PMID: 21493670. |
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3. Swarnkar G, Sharan
K, Siddiqui JA, Mishra JS, Khan K, Khan MP, Gupta V, Rawat
P, Maurya R, Dwivedi AK, Sanyal S, Chattopadhyay
N. Identification of a rare naringenin analog
from a medicinal plant having potent bone anabolic effect
by acting as an osteoblast oestrogen mimic. Br J Pharmacol
(in press), PMID: 21864313. |
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Bhargavan B, Singh D,
Gautam AK, Mishra JS, Kumar A, Goel A, Dixit M, Pandey
R, Manickavasagam L, Dwivedi SD, Chakravarti B, Jain GK,
Ramachandran R, Maurya R, Trivedi A, Chattopadhyay
N, Sanyal S. Medicarpin, a legume phytoalexin,
stimulates osteoblast differentiation and promotes peak
bone mass achievement in rats: evidence for estrogen receptor
?-mediated osteogenic action of medicarpin. J Nutr
Biochem (in press), PMID: 21333515. |
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Siddiqui JA, Swarnkar
A, Sharan K, Chakravarti B, Gautam AK, Rawat P, Kumar
M, Gupta V, Manickavasagam L, Dwivedi AK, Maurya R,
Chattopadhyay N. A naturally occurring
rare analogue of quercetin promotes peak bone mass achievement
and exerts anabolic effect on osteoporotic bone. Osteoporos
Int (in press), PMID: 21225417. |
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Chakravarti B, Siddiqui
JA, Dhar Dwivedi SK, Deshpande S, Samanta K, Bhatta RS,
Panda G, Prabhakar YS, Konwar R, Sanyal S, Chattopadhyay
N. Specific targeting of insulin-like growth
factor 1 receptor signaling in human estrogen dependent
breast cancer cell by a novel tyrosine-based benzoxazepine
derivative. Mol Cell Endocrinol 338:68-78, 2011. |
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Swarnkar G, Sharan K,
Siddiqui JA, Chakravarti B, Rawat P, Kumar M, Arya KR,
Maurya R, Chattopadhyay N. A novel
flavonoid isolated from the steam-bark of Ulmus Wallichaiana
Planchon stimulates osteoblast function and inhibits osteoclast
and adipocyte differentiation. Eur J Pharmacol 658:65-73,
2011. |
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Gautam AK, Bhargavan B,
Tyagi AM, Srivastava K, Yadav DK, Kumar M, Akanksha, Mishra
JS, Singh AB, Sanyal S, Maurya R, Mackivasagam L, Singh
SP, Wahajuddin, Jain GK, Chattopadhyay N,
Singh D. Differential effects of formononetin and cladrin
on osteoblast function, peak bone mass achievement and
bioavailability in rats. J Nutr Biochem 22:318-27,
2011. |
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Yadav DK, Gautam AK, Kureel
J, Srivastava K, Sahai M, Singh D, Chattopadhyay
N, Maurya R. Synthetic analogues of daidzein,
having more potent osteoblast stimulating effect.
Bioorg Med Chem Lett 21:677-81, 2011. |
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Siddiqui JA, Sharan K,
Swarnkar G, Rawat P, Kumar M, Manickavasagam L, Maurya
R, Pierroz D, Chattopadhyay N.
Quercetin-6-C-?-D-glucopyranoside isolated from Ulmus
Wallichiana-planchon is more potent than quercetin
in inhibiting osteoclastogenesis and mitigating ovariectomy-induced
bone loss in rats. Menopause 18:198-217, 2011.
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Kumar M, Rawat P, Dixit
P, Mishra D, Gautam AK, Pandey R, Singh D, Chattopadhyay
N, Maurya R. Anti-osteoporotic constituents
from Indian medicinal plants. Phytomedicine 17:993-9,
2010. |
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Tyagi AM, Gautam AK,
Kumar A, Srivastava K, Bhargavan B, Trivedi R, Yadav
DK, Singh N, Pollet C, Brazier M, Mentaverri R, Chattopadhyay
N, Goel A, Singh D. Medicarpin inhibits
osteoclastogenesis and has nonestrogenic bone conserving
effect in ovariectomized mice. Mol Cell Endocrinol
325:101-9, 2010. |
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13. Siddiqui JA, Swarnakr
G, Sharan K, Chakravarti B, Sharma G, Rawat P, Kumar
M, Pierroz D, Maurya R, Chattopadhyay N.
8,8”-biapigeninyl stimulates osteoblast functions
and inhibits osteoclast and adipocyte functions: osteoprotective
action of 8,8”-biapigeninyl in ovariectomized
mice. Mol Cell Endocrinol 323:256-67, 2010. |
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Pandey R, Gautam AK,
Bhargavan B, Trivedi R, Swarnkar G, Nagar GK, Yadav
DK, Kumar M, Rawat P, Manickivasagam L, Maurya R, Goel
A, Jain GK, Chattopadhyay N,
Singh D. Total extract and standardized fraction from
the stem-bark of Butea monosperma have osteoprotective
action: evidence for the non-estrogenic osteogenic effect
of the standardized fraction. Menopause 17:602-10,
2010. |
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Sharan K, Swarnkar
S, Siddiqui JA, Kumar A, Rawat P, Kumar M, Nagar GK,
Manickavasagam L, Singh SP, Mishra G, Wahajuddin, Jain
GK, Maurya R, Chattopadhyay N.
A Novel flavonoid, 6-C-?-D-glucopyranosyl-(2S,3S)-(+)-3’,4’,5,7-tetrahydroxyflavanone,
isolated from Ulmus wallichiana-planchon mitigates
ovariectomy-induced osteoporosis in rats. Menopause
17:577-86, 2010. |
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Sharan K, Siddiqui
JA, Swarnkar S, Tyagi AM, Kumar A, Rawat P, Kumar M,
Arya KR, Manickivasagam L, Jain GK, Maurya R, Chattopadhyay
N. Extract and fraction of Ulmus wallichiana
planchon promote peak bone achievement and have
non-estrogenic osteoprotective effect. Menopause
17:393-402, 2010. |
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Samanta K, Chakravarti
B, Mishra JK, Dwivedi SK, Nayak LV, Choudhry P, Bid
HK, Konwar R, Chattopadhyay N,
Panda G. Anti-tumor activity of a new series of a benzoxazepin
derivatives in brest cancer. Bioorg Med Chem Lett
20:283-87, 2010. |
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Bhargavan B, Gautam
AK, Singh D, Kumar A, Chaurasia S, Tyagi AM, Yadav DK,
Mishra JS, Singh AB, Sanyal S, Goel A, Maurya R, Chattopadhyay
N. Methoxylated isoflavones, cajanin and
isoformononetin, have non-estrogenic bone forming effect
via differential mitogen activated protein kinase (MAPK)
signaling. J Cell Biochem 108:388-99, 2009.
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Rawat P, Kumar M, Sharan
K, Chattopadhyay N, Maurya R.
Ulmosides A and B: flavonoid 6-C-glycosides from Ulmus
wallichiana, stimulating osteoblast differentiation
assessed by alkaline phosphatase. Bioorg Med Chem
Lett 19:4684-7, 2009. |
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Trivedi R, Kumar A, Gupta
V, Kumar S, Nagar GK, Romero JR, Dwivedi AK, Chattopadhyay
N. Effects of Egb 761 on bone mineral density,
bone microstructure, and osteoblast function: Possible
roles of quercetin and kaempferol. Mol Cell Endocrinol
302:86-91, 2009 |
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Singh US, Shankar R, Kumar
A, Trivedi R, Nishi, Palne S, Gupta S, Chattopadhyay
N, Hajela K. Synthesis and biological evaluation
of indolyl bisphosphonates as anti-bone resorptive and
anti-Leishmanial agent. Bioorg Med Chem 16:8482-91,
2008. |
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Chattopadhyay
N, Espinosa-Jeffrey A, Tfelt-Hansen J,
Yano S, Bandyopadhyay S, Brown EM, de Vellis J. Calcium
receptor expression and function in oligodendrocyte
commitment and lineage progression: potential impact
on reduced MBP in CaR-null mice. J Neurosci Res
86:2159-67, 2008. |
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Trivedi R, Kumar S,
Kumar A, Siddiqui JA, Swarnkar G, Gupta V, Kendurkar
A, Dwivedi AK, Romero JR, Chattopadhyay N.
Kempferol has osteogenic effect in ovariectomized adult
Sprague Dawley rats. Mol Cell Endocrinol 287:57-64,
2008. |
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Bandyopadhyay S, Romero
JR, Chattopadhyay N. Kaempferol
and quercetin stimulate granulocyte-macrophage colony
stimulating-factor secretion in human prostate cancer
cells. Mol Cell Endocrinol 289:85-93, 2008. |
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Sharan K, Siddiqui
JA, Swarnkar G, Chattopadhyay N. Role of calcium-sensing
receptor in bone biology. Symposium on ‘Nutrition
and Bone Health’ by Nutrition Foundation of India.
Ind J Med Res. 127:274-86, 2008. (Review). |
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Trivedi R, Mithal A,
Chattopadhyay N. Calcium-sensing
receptor as a drug target. Curr Med Chem 15:178-186,
2008. (Review). |
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Sharan K, Siddiqui
JA, Maurya R, Chattopadhyay N.
Role of phytochemicals in the prevention of menopausal
bone loss: evidence from in vitro and in vivo, human
interventional and pharmacokinetic studies. Curr
Med Chem 16:1138-57, 2009. (Review). |
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Trivedi R, Mithal A,
Chattopadhyay N. Pharmacological
manipulations of calcium-sensing receptor: prospect
as anabolic therapy for postmenopausal osteoporosis.
Drugs of Future 34:803-809, 2009. (Review). |
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Trivedi R, Mithal A,Chattopadhyay
N. Anabolics in osteoporosis: the emerging
therapeutic tool. Curr Mol Med 10:14-28, 2010.
(Review). |
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Trivedi R, Goswami R,
Chattopadhyay N. Investigational
anabolic therapies for osteoporosis. Expert Opin Investig
Drugs 19:995-1005, 2010. (Review). |
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