DR. NAIBEDYA CHATTOPADHYAY
 
..

Scientist F & Deputy Director
Scientist-in-Charge
Endocrinology Division
Central Drug Research Institute
Lucknow - 226 001, India
 
Educational Qualifications M.Sc ( Presidency College, Calcutta) , Ph.D. ( SGPGI )
Date of Birth 25.05.1965
Phone 091-522-2613894 (O)
Fax 091-522-2623405, 2623938
E-Mail n_chattopadhyay@cdri.res.in
 
 POST-DOCTORAL POSITIONS
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 1994 -1998 Endocrine-Hypertension Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
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 11/1998- 06/2003 Instructor in Medicine, Harvard Medical School, Endocrine-Hypertension Division, Brigham and Women’s Hospital, Boston, MA.
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 07/2003-04/2006 Assistant Professor of Medicine, Harvard Medical School, Division of Endocrinology, Diabetes & Hypertension, Brigham and Women’s Hospital, Boston, MA.
 
CURRENT AREAS OF INTEREST
 
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 Bone anabolic agents
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New chemical entities against breast cancer
 
PUBLICATIONS AT A GLANCE

Total no. of publications: – 115 [Research articles – 85, Invited reviews - 22, Proceedings of meetings – 4, Boos & Monographs – 4

Citation Analysis- Sum of times cited – 3,021, average citation per item- 35.13, average citation per year- 188.81, h-index for original articles - 34
 
LIST OF PUBLICATIONS IN LAST 2 YEARS
 
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 Sharan K, Swarnkar G, Siddiqui JA, Khan K, Kumari R, Rawat P, Maurya R, Sanyal S, Chattopadhyay N. A novel quercetin analog from a medicinal plant promotes peak bone mass achievement, bone healing after injury and exerts anabolic effect on osteoporotic bone: the role of aryl hydrocarbon receptor as a mediator of osteogenic action. J Bone Miner Res 26:2096-2011, 2011.
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 Dhar Dwivedi SK, Singh N, Kumari S, Mishra JS, Tripathi S, Banerjee P, Shah P, Kukshal V, Tyagi AM, Gaikwad AN, Chaturvedi RK, Mishra DP, Trivedi AK, Sanyal S, Chattopadhyay N, Ramachandran R, Siddiqui MI, Bandyopadhyay A, Arora A, Lundåsen T, Anak SP, Moore DD, Sanyal S. Bile acid receptor agonist GW4064 regulates PPAR??coactivator-1??expression through estrogen receptor-related receptor ?. Mol Endocrinol (in press), PMID: 21493670.
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 3. Swarnkar G, Sharan K, Siddiqui JA, Mishra JS, Khan K, Khan MP, Gupta V, Rawat P, Maurya R, Dwivedi AK, Sanyal S, Chattopadhyay N. Identification of a rare naringenin analog from a medicinal plant having potent bone anabolic effect by acting as an osteoblast oestrogen mimic. Br J Pharmacol (in press), PMID: 21864313.
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 Bhargavan B, Singh D, Gautam AK, Mishra JS, Kumar A, Goel A, Dixit M, Pandey R, Manickavasagam L, Dwivedi SD, Chakravarti B, Jain GK, Ramachandran R, Maurya R, Trivedi A, Chattopadhyay N, Sanyal S. Medicarpin, a legume phytoalexin, stimulates osteoblast differentiation and promotes peak bone mass achievement in rats: evidence for estrogen receptor ?-mediated osteogenic action of medicarpin. J Nutr Biochem (in press), PMID: 21333515.
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 Siddiqui JA, Swarnkar A, Sharan K, Chakravarti B, Gautam AK, Rawat P, Kumar M, Gupta V, Manickavasagam L, Dwivedi AK, Maurya R, Chattopadhyay N. A naturally occurring rare analogue of quercetin promotes peak bone mass achievement and exerts anabolic effect on osteoporotic bone. Osteoporos Int (in press), PMID: 21225417.
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 Chakravarti B, Siddiqui JA, Dhar Dwivedi SK, Deshpande S, Samanta K, Bhatta RS, Panda G, Prabhakar YS, Konwar R, Sanyal S, Chattopadhyay N. Specific targeting of insulin-like growth factor 1 receptor signaling in human estrogen dependent breast cancer cell by a novel tyrosine-based benzoxazepine derivative. Mol Cell Endocrinol 338:68-78, 2011.
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 Swarnkar G, Sharan K, Siddiqui JA, Chakravarti B, Rawat P, Kumar M, Arya KR, Maurya R, Chattopadhyay N. A novel flavonoid isolated from the steam-bark of Ulmus Wallichaiana Planchon stimulates osteoblast function and inhibits osteoclast and adipocyte differentiation. Eur J Pharmacol 658:65-73, 2011.
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 Gautam AK, Bhargavan B, Tyagi AM, Srivastava K, Yadav DK, Kumar M, Akanksha, Mishra JS, Singh AB, Sanyal S, Maurya R, Mackivasagam L, Singh SP, Wahajuddin, Jain GK, Chattopadhyay N, Singh D. Differential effects of formononetin and cladrin on osteoblast function, peak bone mass achievement and bioavailability in rats. J Nutr Biochem 22:318-27, 2011.
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 Yadav DK, Gautam AK, Kureel J, Srivastava K, Sahai M, Singh D, Chattopadhyay N, Maurya R. Synthetic analogues of daidzein, having more potent osteoblast stimulating effect. Bioorg Med Chem Lett 21:677-81, 2011.
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 Siddiqui JA, Sharan K, Swarnkar G, Rawat P, Kumar M, Manickavasagam L, Maurya R, Pierroz D, Chattopadhyay N. Quercetin-6-C-?-D-glucopyranoside isolated from Ulmus Wallichiana-planchon is more potent than quercetin in inhibiting osteoclastogenesis and mitigating ovariectomy-induced bone loss in rats. Menopause 18:198-217, 2011.
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 Kumar M, Rawat P, Dixit P, Mishra D, Gautam AK, Pandey R, Singh D, Chattopadhyay N, Maurya R. Anti-osteoporotic constituents from Indian medicinal plants. Phytomedicine 17:993-9, 2010.
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Tyagi AM, Gautam AK, Kumar A, Srivastava K, Bhargavan B, Trivedi R, Yadav DK, Singh N, Pollet C, Brazier M, Mentaverri R, Chattopadhyay N, Goel A, Singh D. Medicarpin inhibits osteoclastogenesis and has nonestrogenic bone conserving effect in ovariectomized mice. Mol Cell Endocrinol 325:101-9, 2010.

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13. Siddiqui JA, Swarnakr G, Sharan K, Chakravarti B, Sharma G, Rawat P, Kumar M, Pierroz D, Maurya R, Chattopadhyay N. 8,8”-biapigeninyl stimulates osteoblast functions and inhibits osteoclast and adipocyte functions: osteoprotective action of 8,8”-biapigeninyl in ovariectomized mice. Mol Cell Endocrinol 323:256-67, 2010.
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Pandey R, Gautam AK, Bhargavan B, Trivedi R, Swarnkar G, Nagar GK, Yadav DK, Kumar M, Rawat P, Manickivasagam L, Maurya R, Goel A, Jain GK, Chattopadhyay N, Singh D. Total extract and standardized fraction from the stem-bark of Butea monosperma have osteoprotective action: evidence for the non-estrogenic osteogenic effect of the standardized fraction. Menopause 17:602-10, 2010.
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Sharan K, Swarnkar S, Siddiqui JA, Kumar A, Rawat P, Kumar M, Nagar GK, Manickavasagam L, Singh SP, Mishra G, Wahajuddin, Jain GK, Maurya R, Chattopadhyay N. A Novel flavonoid, 6-C-?-D-glucopyranosyl-(2S,3S)-(+)-3’,4’,5,7-tetrahydroxyflavanone, isolated from Ulmus wallichiana-planchon mitigates ovariectomy-induced osteoporosis in rats. Menopause 17:577-86, 2010.
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Sharan K, Siddiqui JA, Swarnkar S, Tyagi AM, Kumar A, Rawat P, Kumar M, Arya KR, Manickivasagam L, Jain GK, Maurya R, Chattopadhyay N. Extract and fraction of Ulmus wallichiana planchon promote peak bone achievement and have non-estrogenic osteoprotective effect. Menopause 17:393-402, 2010.
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Samanta K, Chakravarti B, Mishra JK, Dwivedi SK, Nayak LV, Choudhry P, Bid HK, Konwar R, Chattopadhyay N, Panda G. Anti-tumor activity of a new series of a benzoxazepin derivatives in brest cancer. Bioorg Med Chem Lett 20:283-87, 2010.

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Bhargavan B, Gautam AK, Singh D, Kumar A, Chaurasia S, Tyagi AM, Yadav DK, Mishra JS, Singh AB, Sanyal S, Goel A, Maurya R, Chattopadhyay N. Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling. J Cell Biochem 108:388-99, 2009.

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Rawat P, Kumar M, Sharan K, Chattopadhyay N, Maurya R. Ulmosides A and B: flavonoid 6-C-glycosides from Ulmus wallichiana, stimulating osteoblast differentiation assessed by alkaline phosphatase. Bioorg Med Chem Lett 19:4684-7, 2009.

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 Trivedi R, Kumar A, Gupta V, Kumar S, Nagar GK, Romero JR, Dwivedi AK, Chattopadhyay N. Effects of Egb 761 on bone mineral density, bone microstructure, and osteoblast function: Possible roles of quercetin and kaempferol. Mol Cell Endocrinol 302:86-91, 2009
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 Singh US, Shankar R, Kumar A, Trivedi R, Nishi, Palne S, Gupta S, Chattopadhyay N, Hajela K. Synthesis and biological evaluation of indolyl bisphosphonates as anti-bone resorptive and anti-Leishmanial agent. Bioorg Med Chem 16:8482-91, 2008.
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Chattopadhyay N, Espinosa-Jeffrey A, Tfelt-Hansen J, Yano S, Bandyopadhyay S, Brown EM, de Vellis J. Calcium receptor expression and function in oligodendrocyte commitment and lineage progression: potential impact on reduced MBP in CaR-null mice. J Neurosci Res 86:2159-67, 2008.
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Trivedi R, Kumar S, Kumar A, Siddiqui JA, Swarnkar G, Gupta V, Kendurkar A, Dwivedi AK, Romero JR, Chattopadhyay N. Kempferol has osteogenic effect in ovariectomized adult Sprague Dawley rats. Mol Cell Endocrinol 287:57-64, 2008.
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Bandyopadhyay S, Romero JR, Chattopadhyay N. Kaempferol and quercetin stimulate granulocyte-macrophage colony stimulating-factor secretion in human prostate cancer cells. Mol Cell Endocrinol 289:85-93, 2008.
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Sharan K, Siddiqui JA, Swarnkar G, Chattopadhyay N. Role of calcium-sensing receptor in bone biology. Symposium on ‘Nutrition and Bone Health’ by Nutrition Foundation of India. Ind J Med Res. 127:274-86, 2008. (Review).
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Trivedi R, Mithal A, Chattopadhyay N. Calcium-sensing receptor as a drug target. Curr Med Chem 15:178-186, 2008. (Review).
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Sharan K, Siddiqui JA, Maurya R, Chattopadhyay N. Role of phytochemicals in the prevention of menopausal bone loss: evidence from in vitro and in vivo, human interventional and pharmacokinetic studies. Curr Med Chem 16:1138-57, 2009. (Review).
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Trivedi R, Mithal A, Chattopadhyay N. Pharmacological manipulations of calcium-sensing receptor: prospect as anabolic therapy for postmenopausal osteoporosis. Drugs of Future 34:803-809, 2009. (Review).
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Trivedi R, Mithal A,Chattopadhyay N. Anabolics in osteoporosis: the emerging therapeutic tool. Curr Mol Med 10:14-28, 2010. (Review).
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 Trivedi R, Goswami R, Chattopadhyay N. Investigational anabolic therapies for osteoporosis. Expert Opin Investig Drugs 19:995-1005, 2010. (Review).