Dr. P. KALPANA MURTHY
..
Scientist G
Division of Parasitology
Central Drug Research Institute
Lucknow-226 001
 
Educational Qualifications M.Sc., Ph.D.
Date of Birth 17th December 1951
E-Mail psr_murthy[at]yahoo dot com , drkalpana[at]yahoo dot com , drpkmurthy[at]yahoo dot com
Fax No.

91-0522-223405
 
POST DOCTORAL RESEARCH
 
Visiting Scientist CNRS-CSIR bilateral Exchange programme, Pasteur, Institute, Paris, France, 1988
Senior Research Associate, Tulane Primate Research Centre, LA, USA 1998
 
RESEARCH EXPERIENCE
 
•
 Chemotherapy (30 yrs)
•
 Immunopathology of filariasis (15 yrs)
 
CURRENT AREAS OF INTEREST
 
•
 Drug Development, Model Development and & Immunology of lymphatic Filariasis
SELECTED PUBLICATIONS
 
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 Gaur RL, Sahoo MK, Dixit S, Fatma N, Rastogi S, Kulshreshtha DK, Chatterjee RK and Murthy PK - Antifilarial activity of Caesalpinia bonducella against experimental filarial infections (2008) - Ind. J. Med. Res 128, 65-70
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 Gaur RL, Sahoo MK, Dixit S, Joseph SK and Murthy PK - Identification of Brugia malayi adult worm molecules immunoreactive with sera of infected animals treated with antifilarial and re-infected with homologous infection and their role in establishment of infection in Mastomys coucha (2008) - Med Chem Research 17, 445-461
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 Murthy PK, Dixit, S, Gaur, RL, Kumar R, Sahoo, MK, Shakya, N, Joseph SK, Palne S and Gupta Suman - Influence of Brugia malayi life stages and BmAFII fraction on experimental Leishmania donovani infection in hamsters (2008) - Acta Tropica 106, 81-89
•
 Singh BK, Mishra Mridul, Saxena Nisha, Yadav GP, Maulik PR, Sahoo MK, Gaur RL, Murthy PK and Tripathi RP - Synthesis of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines as a new class of antifilarial agents (2008) - Eur. J. Med. Chem. 43, 2717-2723
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 Gaur RL, Dixit S, Sahoo MK, Khanna M, Singh S and Murthy PK. - Anti-filarial activity of novel formulations of albendazole against experimental brugian filariasis. (2007) - Parasitology 134, 537-544
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 Singh SK, Kaushal DC, Murthy PK and Kaushal NA - Partial purification and characterization of acetylcholinesterase isozymes from adult bovine filarial parasite Setaria cervi. (2007) - Indian J. Biochem. Biophys 44 379-385
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 Dixit, S., Gaur, R.L., Sahoo, M.K., Joseph, S.K., Murthy, P.S.R. and Murthy, P.K. - Protection against L3 induced Brugia malayi infection in Mastomys coucha pre-immunized with BmAFII fraction of the filarial adult worm (2006) - Vaccine, Volume 24, Issue 31-32. 5824-5831
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 Gaur, RL, Sahoo Malay K, Khanna Madhu, Singh Satyawan & Murthy P Kalpana. - Antifilarial activity of novel formulations of albendazole against experimental burgian filariasis. (2006) - Parasitology, 2, 1-8.
•
 Murthy, Kalpana P & Sharma R K. - Changing paradigm of filarial perspectives. (2006) - Proceedings National Academy Sciences, 75B, 205-28.
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 Khan, M.A. , Dixit, S. Gaur, R.L. , Murthy, P.S.R. , Saxena, J.K. & Murthy, P.K. - . Correlation between chronocity of infection and host’s lymphoid cell proliferation and DNA damage (2005) - Current Science, 88, 1469-1473
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 Dikshit, S. ,Gaur, R.L. ,Khan, M.A. ,Saxena, J.K. ,Murthy, P.S.R. & Murthy, P.K. - Identification Of burgia malayi antigens of inflammatory potential using THP-1 cells and arodent model. (2004) - Parasite Immunology, 26,,397-407
•
 Response of Brugia malayi- Indian Leaf Monkey (Presbytis entellus), a non-human primate Model of Filariasis, to diethylcarbamazine, ivermectin and CDRI Compond, 82-437. P K Murthy, K Srivastava and P S R Murthy. Current Science 86: 432-39, (2004)
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 7-O-[4-methyl piperazine-1- (2-acetyl0]-2H-1-benzopyran-2-one : A Novel Antifilarial Lead Compound, R.P tripathi, V K Tiwari, S Misra-Bhattacharya, K Tyagi, V M L Srivastava and P K Murthy. Acta Tropica 87: 215-224, 2003
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 Preadult stage of parasite is involved in the development of filarial limb edema in Brugia malayi -infected Indian leaf monkey (Presbytis entellus). P.K. Murthy, M.A. Khan, H.B. Rajani, and V.M.L. Srivastava. Clin. Diag. Lab. Immunol. 9:913-918, 2002.
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 Interleukin 10 modulates proinflammatory cytokines in the human monocytic cell line THP-1 stimulated with Borrelia burgdorferi lipoprotein. P.K. Murthy, V.A. Dennis, B.L. Lasater, and T. Philipp. Mario. Infection and Immunity, 68: 6663-6669, 2000.
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 Longitudinal humoral immune responses of Indian leaf monkey (Presbytis entellus) to Brugia malayi infection. P.K. Murthy, K. Tyagi, R.P. Ghosh, P.S.R. Murthy, and R.K. Chatterjee. Parasitology, 119: 53-60, 1999.