Dr. P. KALPANA MURTHY
..
Scientist G
Division of Parasitology
Central Drug Research Institute
Lucknow-226 001
 
Educational Qualifications M.Sc., Ph.D.
Date of Birth 17th December 1951
E-Mail psr_murthy[at]yahoo dot com , drkalpana[at]yahoo dot com , drpkmurthy[at]yahoo dot com
Fax No.

91-0522-223405

 
POST DOCTORAL RESEARCH
 
Visiting Scientist CNRS-CSIR bilateral Exchange programme, Pasteur, Institute, Paris, France, 1988
Senior Research Associate, Tulane Primate Research Centre, LA, USA 1998
 
RESEARCH EXPERIENCE
 
Chemotherapy (30 yrs)
Immunopathology of filariasis (15 yrs)
 
CURRENT AREAS OF INTEREST
 
Drug Development, Model Development and & Immunology of lymphatic Filariasis
SELECTED PUBLICATIONS
 
Gaur RL, Sahoo MK, Dixit S, Fatma N, Rastogi S, Kulshreshtha DK, Chatterjee RK and Murthy PK - Antifilarial activity of Caesalpinia bonducella against experimental filarial infections (2008) - Ind. J. Med. Res 128, 65-70
Gaur RL, Sahoo MK, Dixit S, Joseph SK and Murthy PK - Identification of Brugia malayi adult worm molecules immunoreactive with sera of infected animals treated with antifilarial and re-infected with homologous infection and their role in establishment of infection in Mastomys coucha (2008) - Med Chem Research 17, 445-461
Murthy PK, Dixit, S, Gaur, RL, Kumar R, Sahoo, MK, Shakya, N, Joseph SK, Palne S and Gupta Suman - Influence of Brugia malayi life stages and BmAFII fraction on experimental Leishmania donovani infection in hamsters (2008) - Acta Tropica 106, 81-89
Singh BK, Mishra Mridul, Saxena Nisha, Yadav GP, Maulik PR, Sahoo MK, Gaur RL, Murthy PK and Tripathi RP - Synthesis of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines as a new class of antifilarial agents (2008) - Eur. J. Med. Chem. 43, 2717-2723
Gaur RL, Dixit S, Sahoo MK, Khanna M, Singh S and Murthy PK. - Anti-filarial activity of novel formulations of albendazole against experimental brugian filariasis. (2007) - Parasitology 134, 537-544
Singh SK, Kaushal DC, Murthy PK and Kaushal NA - Partial purification and characterization of acetylcholinesterase isozymes from adult bovine filarial parasite Setaria cervi. (2007) - Indian J. Biochem. Biophys 44 379-385
Dixit, S., Gaur, R.L., Sahoo, M.K., Joseph, S.K., Murthy, P.S.R. and Murthy, P.K. - Protection against L3 induced Brugia malayi infection in Mastomys coucha pre-immunized with BmAFII fraction of the filarial adult worm (2006) - Vaccine, Volume 24, Issue 31-32. 5824-5831
Gaur, RL, Sahoo Malay K, Khanna Madhu, Singh Satyawan & Murthy P Kalpana. - Antifilarial activity of novel formulations of albendazole against experimental burgian filariasis. (2006) - Parasitology, 2, 1-8.
Murthy, Kalpana P & Sharma R K. - Changing paradigm of filarial perspectives. (2006) - Proceedings National Academy Sciences, 75B, 205-28.
Khan, M.A. , Dixit, S. Gaur, R.L. , Murthy, P.S.R. , Saxena, J.K. & Murthy, P.K. - . Correlation between chronocity of infection and host’s lymphoid cell proliferation and DNA damage (2005) - Current Science, 88, 1469-1473
Dikshit, S. ,Gaur, R.L. ,Khan, M.A. ,Saxena, J.K. ,Murthy, P.S.R. & Murthy, P.K. - Identification Of burgia malayi antigens of inflammatory potential using THP-1 cells and arodent model. (2004) - Parasite Immunology, 26,,397-407
Response of Brugia malayi- Indian Leaf Monkey (Presbytis entellus), a non-human primate Model of Filariasis, to diethylcarbamazine, ivermectin and CDRI Compond, 82-437. P K Murthy, K Srivastava and P S R Murthy. Current Science 86: 432-39, (2004)
7-O-[4-methyl piperazine-1- (2-acetyl0]-2H-1-benzopyran-2-one : A Novel Antifilarial Lead Compound, R.P tripathi, V K Tiwari, S Misra-Bhattacharya, K Tyagi, V M L Srivastava and P K Murthy. Acta Tropica 87: 215-224, 2003
Preadult stage of parasite is involved in the development of filarial limb edema in Brugia malayi -infected Indian leaf monkey (Presbytis entellus). P.K. Murthy, M.A. Khan, H.B. Rajani, and V.M.L. Srivastava. Clin. Diag. Lab. Immunol. 9:913-918, 2002.
Interleukin 10 modulates proinflammatory cytokines in the human monocytic cell line THP-1 stimulated with Borrelia burgdorferi lipoprotein. P.K. Murthy, V.A. Dennis, B.L. Lasater, and T. Philipp. Mario. Infection and Immunity, 68: 6663-6669, 2000.
Longitudinal humoral immune responses of Indian leaf monkey (Presbytis entellus) to Brugia malayi infection. P.K. Murthy, K. Tyagi, R.P. Ghosh, P.S.R. Murthy, and R.K. Chatterjee. Parasitology, 119: 53-60, 1999.