Biodata of Dr P K Shukla :::: Central Drug Research Institute

Dr. P.K. SHUKLA

Fermentation Technology Division
Central Drug Research Institute,
Post Box No. 173,
LUCKNOW 226 001
INDIA

Educational qualifications	M.Sc., Ph.D.
Phone No.	2612411-18 Ext.4256 (O), 0512-2364148 (R)
E-Mail	p_kshukla@yahoo.com
Date of birth	May 20, 1959

POSITIONS HELD

Lecturer in Medical Mycology T.U.Teaching Hospital Institute of Medicine Maharajgunj, Kathmandu, Nepal

RESEARCH EXPERIENCE/TRAINNING

•	Senior Research Fellow and Research Associate (ICMR, New Delhi, India)
•	Department of Ophthalmology, King George's Medical College, and Medical Mycology Division, C.D.R.I., Lucknow, India.

CURRENT AREAS OF INTEREST

•	Medical Mycology, Immunodiagnosis
•	Chemo/Immuno therapy of fungal infection

MEMBERSHIPS OF PROFESSIONAL SOCIETIES

•	International Society for Human and Animal Mycology (USA)
•	Society for Indian Human and Animal Mycologists (SIHAM), India, Life member
•	International Society of Applied Biology, India, Life member
•	The U.P.Association for the Science and Technology Advancement. Life member

Honours and Awards : Received best paper presentation award at the 32nd Annual Conference of Association of Microbiologists of India, Madurai (Jan10-12, 1992)

Publications and Patents: More than 40 papers and 14 patents.

Selected Publications
•	A novel dodecapeptide from combinatorial synthetic library exhibits potent antifungal activity and synergy with standard antimycotic agents. S. Duggineni, G. Srivastava, B. Kundu, Manish Kumar, Ashok K Chaturvedi and P.K.Shukla. Int. J. Antimicob. Agents. (2007) 29, 73–78.
•	Design and synthesis of fluconazole-bile acid conjugate using click reaction. Vandana S. Pore, Nilkanth G. Aher, M. Kumar and P.K.Shukla. Tetrahedron (2006) 62, 11178-11186.
•	Antifungal anthraquinones from Saprosma fragrans. D. N. Singh, N. Verma, S. Raghuwanshi, P. K. Shukla and D. K. Kulshreshtha. Bioorganic & Medicinal Chemistry Letters 16 (2006) 4512–4514.
•	Design, synthesis, and biological evaluation of 1,2,3-trisubstituted-1,4-dihydrobenzo[g]quinoxaline-5,10-diones and related compounds as antifungal and antibacterial agents Vishnu K. Tandon, Dharmendra B. Yadav, Hardesh K. Maurya, Ashok K. Chaturvedi and Praveen K. Shukla. Bioorganic & Medicinal Chemistry 14 (2006) 6120–6126
•	Single stranded conformation polymorphism of large sub unit of rRNA is best suited to diagnosing fungal infections and differentiating fungi at species level. Manish Kumar and P. K. Shukla. Diag. Microbiol. Infect. Dis. (2006). 56, 45-51.
•	Candidacidal activity of a monoclonal antibody that binds with glycosyl moieties of proteins of Candida albicans Wall Proteins. Amol Kavishwar and P.K Shukla. Medical Mycology (2006), 44, 159-167.
•	Use of PCR targeting of internal transcribed spacer regions and single-stranded conformation polymorphism analysis of sequence variation in different regions of rRNA genes in fungi for rapid diagnosis of mycotic keratitis. Manish Kumar and P.K.Shukla (2005). J. Clin. Microbiol.vol. 43 (2), 662-668.
•	Synthesis of 4-hydroxy-1-methylindole and benzo[b]thiophen-4-ol based unnatural flavonoids as new class of antimicrobial agents. Prem P. Yadav, Prasoon Gupta, A.K.Chaturvedi, P.K.Shukla and Rakesh Maurya. (2005). Bioorg. Med. Chem. 13, 1497-1505.
•	Identification of a novel antifungal nonapeptide generated by combinatorial approach. Manish kumar, Ashok k. Chaturvedi, Amol Kavishwar, P.K.Shukla, A.P. Kesarwani and B. Kundu. (2005) International J. Antimicrob. Agents. 25, 313-320.
•	Synthesis of (1,4)-naphthoquinono-(3,2-c)-1 H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal antibacterial and anticancer agents. V.K.Tandon, D.B.Yadav, A.K.Chaturvedi and P.K.Shukla. (2005). Bioor. Med. Chem. Lett. 15, 3288–3291.
•	Synthesis and biological evaluation of novel1,4-naphthoquinone derivatives as antibacterial and antiviral agents. V.K. Tandon, D.B. Yadav, R.V. Singh, Meenu Vaish, A.K. Chaturvedi and P.K. Shukla. Bioor. Med. Chem. Lett. 2005. 15, 3463–3466.
•	Discovery of substituted isoxazolecarbeldehydes as potent spermicides, acrosin inhibitors and mild antifungal agents.G. Gupta, R.K.Jain, J.P.Maikhuri, P.K.Shukla, M. Kumar, K.Roy, A. Patra, V. Singh and S. Batra. Human Reproduction 2005. 20, 2301-2308.
•	Identification of Aspergillus fumigatus secretory proteins and their immunohistochemical demonstration in mouse model. S.K Raghuwanshi, Manish Kumar, A. Kavishwar, Ashok K. Chaturvedi, P.S.R Murthy and P.K. Shukla. Mycoses (2005). 48, 313-320.
•	Monoclonal Immunoglobulin G1 directed against Aspergillus fumigatus cell wall glycoprotein protects against experimental murine aspergillosis. A.K.Chaturvedi, A. Kavishwar, G.B.Shiva Keshava and P.K.Shukla. Clinical and Diagnostic Laboratory Immunology (2005) 12, 1063-1068.
•	Sensitive and rapid PCR based diagnosis of mycotic keratitis through single stranded conformation polymorphism Manish Kumar, N.K.Mishra, and P.K.Shukla. American J. Ophthalmology (2005) 140 (5), 858-865.
•	Synthesis and biological evaluation of novel (L)-a-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. Vishnu K. Tandon, Dharmendra Yadav, Ravindra V. Singh, Ashok K. Chaturvedi and P.K. Shukla. Bioorganic & Medicinal Chemistry Letters 15 (2005) 5324–5328.