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| Dr.
P.M.S. Chauhan |
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Scientist F
Medicinal & Precess Chemistry Division
Central Drug Research Institute
Chatter Manzil Palace
P.O.Box No. 173
Lucknow, INDIA |
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| Phone No. |
+91-0522-2612411-18-Ext
4332 |
| Fax No. |
+91-0522-2623405 |
| E- mail |
prem_chauhan_2000@yahoo.com |
| Educational Qualifications |
M.Sc. Ph.D |
| Date of Birth |
28th June 1958 |
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| POST
DOCTORAL EXPERIENCE |
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1987 - 1988
(Jan.-Oct.) |
Post Doctoral
Senior Research Associate, Robert Robinson Laboratory,
University of Liverpool, UK with Dr.R.C.Storr. |
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April-July, 2000 |
Senior DAAD Visiting
Scientist, Instituted of Organic Chemistry, RWTH
Aachen, Germany with Prof. D. Enders
and Prof. Stefan Brease |
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2002- 2003 |
Post Doctoral Senior Research
Associate, School of Chemical Sciences, University
East Anglia, Norwich, UK With
Prof. David C. Horwell Former director
Pfizer UK. |
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| RESEARCH
EXPERIENCE |
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| CURRENT
AREA OF INTEREST |
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Medicinal
chemistry (Antimalaria,Antileishmania,Antifilaria, Antituberculosis
and Anticancer) , Synthetic organic chemistry / Combinatorial
chemistry |
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| SELECTED
PUBLICATIONS ( Total Publications till date : 76 Patents : 6 |
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Synthesis of 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted
phenyl)-2,3,4,9-tetrahydro-1H-ß -carbolines as a
new class of antimalarial agents,Leena Gupta, Kumkum Srivastava,
Shubhra Singh, S. K. Puri and Prem M. S. Chauhan*,
Bioorganic and Medicinal Chemistry Letters, 18,
2008, 3306-3309. |
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One-pot chemoselective
S-alkylation and acetylation of thiohydantoins using alkyl
orthoformate-ZnCl2-Ac2O reagent system,Ravi Kumar and
Prem M. S. Chauhan Ravi Kumar and Prem M. S. Chauhan*,
Tetrahedron Letters , 49 ,2008,
5475–5479. |
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Synthesis of 4-amino-5-cyano
-2, 6-Disubsituted pyrimidines as a potential antifilarial
DNA topoisomerase II Inhibitors ,Ashok Kumar,J.K.Saxena
and Prem M. S. Chauhan, Medicinal Chemistry,
4(6), 2008 , 577-585. |
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Synthesis and bioevaluation
of hybrid 4-aminoquinoline triazines as a new class of
antimalarial agents, Ashok Kumar , Kumkum Srivastava ,
S. Raja Kumar , S. K. Puri , Prem M. S. Chauhan,
Bioorganic and Medicinal Chemistry Letters,
18, 2008, 6530–6533. |
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Synthesis of Marine alkaloid:
8, 9-Dihydrocoscinamide B and its analogues as Novel class
of antileishmanial agents,Leena Gupta, Archna Talwa, Nishi,
Shraddha Palne,Suman Gupta and Prem M. S. Chauhan*,
Bioorganic and Medicinal Chemistry Letters,2007,17,
4075–4079. |
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Bis and Tris
Indole Alkaloids from Marine Organisms:New Leads For Drug
Discovery, Leena Gupta, Archna Talwar and Prem
M.S.Chauhan*, Current Medicinal Chemistry, 2007,
14, 16, 1789-1803. |
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Syntheses
of new substituted triazino tetrahydro-isoquinlines and
ß-carbolines as novel antileishmanial agents, Arun
Kumar, Sanjay Babu Katiyar, Suman Gupta and Prem
M. S. Chauhan, European Journal of Medicinal Chemistry,
2006, 41 ,106–113, |
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A Multicomponent
Reaction: Efficiently furnishing Phenylmethylene-2-thiohydantoin
with some unusual consequences.Sharad Porwal, Rishi Kumar,b
Prakas R. Maulik,and Prem M. S. Chauhan, Tetrahedron
Letters ,2006 , 47,5863–5866 |
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Facile synthesis
of pyrazolo[3,4-d]pyrimidines and pyrimido [4,5-d]pyrimidin-4-one
derivatives,Sanjay Babu Katiyar, Arun Kumar and Prem
M. S. Chauhan, Synthetic communications, 36(20),
2006 ,2963-73 |
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Synthesis
of 2,4,6-trisubstituted pyrimidine and triazineheterocycles
as antileishmanial agents ,Naresh Sunduru, Anu Agarwal,Sanjay
Babu Katiyar,Nishi, Neena Goyal,,Suman Gupta and Prem
M.S. Chauhan, Bioorganic and Medicinal Chemistry,
14,2006,7706-7715 |
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Microwave assisted one
pot synthesis of new bis-imidazolyl indoles, Anu Agarwal
,Sharad porwal and Prem M. S. Chauhan,, Letters
in Organic Chemistry, 3,2006,712-714 |
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SELECTED
PATENTS |
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A process of synthesis
of 2,7-diamidino xanthine , thioxantene of Biological
Interest. P.M.S. Chauhan , R.N. lyer
, Veena Shankhadhar , P.Y. Guru , A.B. Sen Indian Pat.
No. 373/DEL/87
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A process of synthesis
of 2,7-diamidino xanthine , thioxantene of Biological
Interest. P.M.S. Chauhan , R.N. lyer
, Veena Shankhadhar , P.Y. Guru , A.B. Sen Indian Pat.
No.
626/DEL/87 |
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A process for the synthesis
of antifilarial 2-(aryl) amino-4,6 -dihydrazinotriazines
. P.M.S. Chauhan , Somnath Singh Puvada
Kalpana Murty , R.K. Chatterjee Patent Indian No. CSIR
India DEL/882/92 |
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A process for the synthesis
of Antifilarial N-(4-cyano pyrazoler-5-ylldithiomethyl
carbamidate , P.M.S. Chauhan , Somnath
Singh,Puvada Kalpana Murty , R.K. Chatterjee. Patent filed
in Indian APP No. NF-201/92-PAT |
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A process for the synthesis
of Antifilarial 4-cyano-5-quanidino pyrazoles
P.M.S. Chauhan , Somnath Singh, Puvada Kalpana
Murty , R.K. Chatterjee Patent No. 1239/DEL 192 (No. 1146
DEL-92. |
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A process for the synthesis
of Antifilarial 2,4 -di-(4 -Chloro-3-nitroanilinyl)-6-amino-S-
Triazine P.M.S. Chauhan, Nigar Fatima
, R.K. Chatterjee Patent filed in India 3rd Dec. 1992.
Pat. No.1148 (Del-92 dt. 3.12.92.) |
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