DR. PRAKAS R MAULIK
 
Scientist F
Molecular and Structural Biology Division
P.O. Box No. 173
Chhattar Manzil
Lucknow -226001
India 		 
E Mail maulik_prakas@yahoo.com
Educational Qualifications M. Sc. (Physics) ; Ph.D. (X-Ray Crystallography, Calcutta University)
Date of Birth 07.02.1950
 
PROFESSIONAL TRAINING
 
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 University of Illinois, Chicago, USA 1982 – 1983
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 Boston University Medical Centre, Boston, USA 1983-1992
RESEARCH AREAS
 
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 Small molecule Crystallography; Macromolecular Crystallography; Molecular Modeling; Membrane Biophysics
 
CURRENT AREAS OF INTEREST
 
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 X-Ray crystallographic studies for structure, conformation & interactions of bio-molecules, mainly anti-diabetic compounds, anti-tubercular compounds & SERMs (anti-fertility, anti-osteoporosis & anti-cancer compounds).
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 In-silico docking studies of the molecules with moderate activity for further knowledge-based synthesis of more active compounds for drug-design.
 
SELECTED PUBLICATIONS
 
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 Synthesis and structure guided evaluation of estrogen agonist and antagonist activities of some new tetrazolyl indole derivatives, Uma Sharan Singh, Ravi Shankar, Gaya P.Yadav, Geetika Kharkwal, Anila Dwivedi, Govind Keshri, M. M. Singh, P. R. Maulik, K Hajela, European J. Medicinal Chemistry, 2008, 43, 2149-2158.
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 Vapor-Phase Processable Novel Nonplanar Donor-Acceptor Quateraryls for Blue OLEDs Atul Goel, Manish Dixit, Sumit Chaurasia, Amit Kumar, Resmi Raghunandan, P. R. Maulik, and R. S. Anand. Organic Letters, 2008, 10(12), 2553-2556.
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 An unusual synthesis of tetrahydrobenzo[f]isoquinolines; Ramendra Pratap, Resmi Raghunandan, P. R. Maulik and Vishnu Ji Ram.Tetrahedron Letters, 2007 48, 7982-7985.
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 C-3 Alkyl/Arylalkyl-2,3-dideoxy Hex-2-enopyranosides as Antitubercular Agents: Synthesis, Biological Evaluation, and QSAR Study. Saquib, M.; Gupta, M. K.; Sagar, R.; Prabhakar, Y. S.; Shaw, A. K.; Kumar, R.; Maulik, P. R.; Gaikwad, A. N.; Sinha, S.; Srivastava, A. K.; Chaturvedi, V.; Srivastava, R.; Srivastava. B.S. J. Medicinal Chemistry, 2007, 50, 2942-2950.
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 1H NMR and crystallographic evidence for tolerance of bulky electron withdrawing methanesulfonyl group on robustness of the U-motif in pyrazolo[3,4-d]pyrimidine core based ‘Leonard linker’ compounds and formation of plus (+) motif. Kamlakar Avasthi, Sheikh M. Farooq, Sangeeta Aswal, Resmi Raghunandan and Prakas R. Maulik. J. Mol. Struct., 2007, 827,88-94.
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 Highly Efficient Non-Palladium-Catalyzed Controlled Synthesis and X-ray Analysis of Functionalized 1,2-Diaryl-, 1,2,3-Triaryl-, and 1,2,3,4-Tetraarylbenzenes. Atul Goel , Fateh Veer Singh, Manish Dixit, Deepti Verma, Resmi Raghunandan, Prakas R Maulik, Chemistry Asian J., 2007, 5, 239-247.
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 Unprecedented SnCl2-Mediated Cyclization of Nitro Arenes via N-N Bond Formation; Devesh Sawant, Rishi Kumar, Prakas R. Maulik, and Bijoy Kundu, Organic Letters, 2006, 8, 1525-1528.
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 Molecular characterization and localization of Plasmodium falciparum choline kinase ; Vinay Choubey, Mithu Guha, Pallab Maity, Sanjay Kumar, Resmi Raghunandan, Prakas R. Maulik, Kalyan Mitra, Umesh C. Halder and Uday Bandyopadhyay, Biochimica et Biophysica Acta (BBA) - General Subjects, 2006, 1760,1027
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 6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-? activators ; Ashoke Sharon, Ramendra Pratap, Rit Vatsyayan, Prakas R. Maulik, Uma Roy, Atul Goel and Vishnu Ji Ram, Bioorganic & Medicinal Chemistry Letters, 2005,15, 3356-3360.
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 Synthesis of Biphenanthrenyls and Role of C-H…X Noncovalent Interactions in Conformational Control. Ashoke Sharon, Prakas R. Maulik, C. Vithana, Y. Ohashi and Vishnu Ji Ram. Eur. J. Org. Chem., 2004, 4, 886-893.
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 Structure-Based Drug Design: Synthesis, Crystal Structure, Biological Evaluation and Docking Studies for Mono- and Bis-benzo[b]oxepines as non-steroidal estrogens. S. Sarkhel, Ashoke Sharon, V. Trivedi, Prakas R. Maulik, M. M. Singh, P. Venugopalan and S. Ray, Bioorg. Med. Chem., 2003, 11, 5025–5033.
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 Absolute Configuration and Anticancer Activity of Taxiresinol and Related Lignans of Taxus wallichiana. S. K. Chattopadhyay, T. R. Santha Kuman, P. R. Maulik, S. Srivastava, A. Garg, Ashoke Sharon, A. S. Negi and Suman Preet S. Khanuja Bioorg. Med. Chem., 2003, 11, 4945–4948.
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 A Convenient Synthesis and Hepatoprotective Activity of Imidazole[1,2-c] Primido[5,4-e]pyrimidine, Tetraazaacenaphthene and Tetraazaphenalene from Cyclic Ketene Aminals Through Tandem Addition-Cyclization Reactions, Vishnu J. Ram, Atul Goel, Sanjay Sarkhel, Prakas R. Maulik, Bioorganic & Medicinal Chemistry, 2002, 10, 1275-1280.
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 1H NMR and X-ray crystallographic analysis of 1,2-bis(4,6-diethylthio-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethane and its ‘propylene linker’-analog: molecular recognition versus crystal engineering:. Kamlakar Avasthi,Diwan S. Rawat, Prakas R. Maulik, S. Sarkhel, Charlotte K. Broder and Judith A. K. Howard, Tetrahedron Letters, 2001, 42, 7115-7117.
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 Dysobinin, a tetranortriterpenoid: Sanjay Sarkhel, Girish K. Jain, Satywan Singh, Hosahalli S. Subramanya and Prakas R. Maulik, Acta Crystallographica, 2000, C56, e253-e254.
  Resolution, Molecular Structure and Biological Activities of the D- and L-Enantiomers of Potent Anti-implantaion Agent DL-2-[4-(2-Piperidinoethoxy)phenyl]-3-phenyl-2H-1-benzopyran: K. Hajela, Jaya Pandey, A. Dwivedy, J. D. Dhar, Sanjay Sarkhel, P. R. Maulik and D. Velumurugan, Bioorg. Med. Chem., 1999, 7, 2083-2090.
  N-Palmitoyl Sphingomyelin Bilayers: Structure and Interactions with Cholesterol and Dipalmitoylphosphatidylcholine: Prakas R. Maulik and G. G. Shipley, Biochemistry, 1996, 35, 8025-8034.
  Interactions of N-Stearoyl Sphingomyelin with Cholesterol and Dipalmitoylphosphatidylcholine in Bilayer Membranes, Prakas R. Maulik and G. G. Shipley, Biophysical Journal, 1996, 70, 2256-2265.
  The 2.4 Å Crystal Structure of Cholera Toxin B Subunit Pentamer: Choleragenoid: Rong-Guang Zhang, Mary L. Westbrook, Edwin M. Westbrook, David L. Scott, Zbyszek Otwinowski, Prakas R. Maulik, Robert A. Reed and G. Graham Shipley, J. Molecular Biology, 1995, 251, 550-562.
  Crystallization and Preliminary X-ray Diffraction Study of Synthetic Apolipoprotein E Fragment (Residues 129-169): Prakas R. Maulik, Robert A. Reed, Doris A. Sparrow, James T. Sparrow, and G. Graham Shipley, Journal of Biological Chemistry, 1990, 265, No. 1, 490-492.
  Crystallization and Preliminary X-ray Diffraction Study of Cholera Toxin B-subunit: Prakas R. Maulik, Robert a. Reed and G. Graham Shipley, Journal of Biological Chemistry, 1988, 263, No. 19, 9499-9501.