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| Dr.
RAJKAMAL TRIPATHI |
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Scientist
Toxicology Division
Central Drug Research Institute
Lucknow-226001
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| Phone No. |
91-0522-2612411-18 |
| Fax No. |
91-0522-2623405, 2623938 |
| E- mail |
rajkamalt@yahoo.com |
| Educational Qualifications |
M.Sc, Ph.D |
| Field of Specialization |
Molecular Immunology,
Viral Immunology |
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| POST
DOCTORAL EXPERIENCE |
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1999-2001
Dept. of Immunology, Duke University, Medical Centre Durham,
USA |
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1996-1999 Centre d’
Immunologie(CMIL), Marsille, France |
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| GROUP
MEMBERS |
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Sudipti (SRF),
Dharamsheela (JRF), Pankaj Singh (JRF) |
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| CURRENT
AREAS OF INTEREST |
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Our area of
interest is in understanding the adverse effects of human
pharmaceuticals on the immune system in vivo and in vitro.
The adverse effect is studied in terms of suppression/enhancement
of immune response and understanding the underlying molecular
mechanism.
Our interest in viral immunology is to understand the
viral and host protein-protein interaction responsible
for immune evasion. We have developed a mammalian two
hybrid model to study HIV-1 Nef and PACS-1 interaction
in eukaryotic cells (HEK293 cells). This interaction essentially
activates the pathway in HIV-1 infected cell for MHC-1
down regulation. We have targeted this interaction as
potential target for developing alternative HIV-1 therapy.
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| SELECTED
PUBLICATIONS |
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Design and synthesis of
2-(2,6-dibromophenyl)-3-heteroaryl-1, 3 thiazolidin-4-ones
as anti-HIV agents Ravindra K. Rawal a, Rajkamal
Tripathi b, S.B. Katti a,*,Christophe Pannecouque
c, Erik De Clercq c European Journal of Medicinal
Chemistry 2008 p. 1-7 |
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Synthesis and evaluation
of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-
one analogues as anti-HIV-1 agents, R. K.Rawal, R.
K.Tripathi, S. B. Katti, C. Pannecouque, Erik
De Clercq, Bioorganic Med. Chem., 2007,
Vol.15, p. 3134-42 |
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Design, synthesis, and
evaluation of 2-aryl-3-heteroaryl-1,3- thiazolidin-4-ones
as anti-HIV agents Ravindra K. Rawal, Rajkamal
Tripathi, S.B. Katti, Christophe Pannecouque
and Erik De Clercq, Bioorganic Med. Chem., 2007,Vol.
15, p. 1725-31. |
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Synthesis and biological
evaluation 2,3-diaryl substituted 1,3, tiazolidin-4-ones
as anti HIV agents. R. K. Rawal, R. K. Tripathi,
S. B. Katti, C. Pannecouque, E. De Clercq, Medicinal Chemistry,
2007 3, 0000 |
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Dengue virus-specific
suppressor T cells: current perspectives. Chaturvedi UC,
Shrivastava R, Tripathi RK, Nagar R.
FEMS Immunol Med Microbiol, 2007 Vol. 3, p. 285-99
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Regulation of V(D)J recombination:
A dominant role for promoter positioning in gene segment
accessibility Michael L. Sikes *, Amber Meade ,
Rajkamal Tripathi , Michael S. Krangel , and
Eugene M. Oltz * , PNAS, 2002, Vol. 99,
no. 19, p.12309-12314 |
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A Change in the Structure
of V Chromatin Associated with TCR Allelic Exclusion1
Rajkamal Tripathi, Annette Jackson and
Michael S. Krangel2 The Journal of Immunology,
2002, Vol. 168, p. 2316-2324 |
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Definition of a T-Cell
Receptor Gene Core Enhancer of V(D)J Recombination by
Transgenic Mapping RajKamal Tripathi,1
Noëlle Mathieu,1 Salvatore Spicuglia,1 Dominique
Payet,1 Christophe Verthuy,1 Gaëlle Bouvier,1 Danielle
Depetris,2 Marie-Geneviève Mattei,2 William M.
HempeL,1 and Pierre Ferrier1,* Molecular and Cellular
Biology, 2000, Vol. 20, p. 42-53 |
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TCRa enhancer activation
occurs via a conformational change of a pre-assembled
nucleo-protein complex Salvatore Spicuglia, Dominique
Payet, RajKamal Tripathi, Pascal Rameil,1
Christophe Verthuy, Jean Imbert,1 Pierre Ferrier,2 and
William M. Hempel3 EMBO J. 2000, Vol.
19(9), p. 2034–2045. |
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Internalization of dengue
virus-induced suppressor cytokine during transmission
of the suppressor signal via macrophage RajKamal
Tripathi ; Khare M.; Chaturvedi U. C.;
Indian J. of Experimental Biology, 1997 Vol.
35, p. 850-854 |
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