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Dr. RAKESH SHUKLA |
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Chief Scientist & In-charge
Division of Pharmacology
Central Drug Research Institute
Post Box 173
Lucknow - 226031 (INDIA)
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| Phone No. |
91- 0522-2772461 Ext
2461 |
| Fax No. |
91-0522-2771941 |
| Educational qualifications |
M.Sc., Ph.D. |
| E-mail |
[email protected] |
| Date of Birth |
August 20, 1956 |
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| INTERNATIONAL
ASSIGNMENTS /VISITS |
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| U.S.A. |
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February1988
- February 1989 |
Visiting Adjunct
Assistant Professor
Department of Pharmacology, Michigan State University,
East Lansing, MI-48824 (USA) |
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March 1989
- May 1990 |
Visiting Scientist
Department of Pharmacology, Wayne State University
540 East Canfield Avenue Detroit, MI - 48201 (USA) |
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| U.K |
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July 29 -
4 - Aug 8, 1984 |
To attend
IUPHAR 9th International Congress of Pharmacology at London
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| RESEARCH
EXPERIENCE |
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Pharmacology
(25 years) |
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| CURRENT
AREAS OF INTEREST |
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Research
interests have been directed towards understanding the
role of neurotransmitters and analysis of receptors involved
in the central control of thermoregulation, central cardiovascular
control and in the regulation of Blood Brain Barrier |
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Biochemical
and immunological mediators in inflammation and Bioevaluation
of anti-inflammatory/arthritic, anti-hypertensive, diuretic
and adaptogenic agents |
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| SELECTED
PUBLICATIONS |
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Agrawal R, Tyagi E,
Shukla R and Nath C - Effect of insulin and melatonin
on acetylcholinesterase activity in brain areas of amnesic
mice (2008) - Behavioral Brain Research 189,
381-386 |
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Rasheed Naila, Tyagi Ethika,
Ahmad Ausaf, Siripurapu Kiran Babu, Lahiri Shawon, Shukla
Rakesh and Palit Gautam - Involvement of monoamines
and proinflammatory cytokines in mediating anti-stress
effects of Panax quinquifolium (2008) - Journal
of Ethnopharmacology 117, 257-262 |
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Sashidhara KV, Rosaiah
JN, Tyagi E, Shukla R, Raghubir R and
Rajendran SM - Rare dipetide and urea derivatives from
roots of Moringa oleifera as potential anti-inflamamtory
and anti-nociceptive agents (2008) - Eur. J. Med.
Chem. 44, 432-436 |
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Shukla R,
Tyagi E and Kumar R - Protective effect of COX and NOS
Inhibitors on LPS induced Oxidative Stress in Rat Brain
(2008) - Annals of Neurosciences 15, 6-10 |
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Tyagi E, Agrawal R, Nath
C and Shukla R - Influence of LPS induced
Neuroinflammation on Acetylcholinesterase activity in
rat brain (2008) - Journal of Neuroimmunology
205, 51-56 |
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Koneni VS, Rosaiah JN,
Tyagi E, Shukla R and Raghubir R - Rare
Dipeptide and Urea derivatives from roots of Moringa Oleifera
as potential Anti-inflammatory and antinociceptive agents
(2007) - Med Chem Res 15, 252-255 |
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Rasheed N, Tyagi E, Siripuarapu
KB, Lahiri S, Shukla R and Palit G -
Involvement of monoamines and proinflammatory cytokines
in mediating anti-stress effect of Panax quinquifolium
(2007) - J. Ethnopharmacology 117, 257-262 |
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Sondhi Sham M, Jain Shubhi,
Dinodia Monica, Shukla Rakesh and Raghubir
Ram - One pot synthesis of pyrimidine and bispyrimidine
derivatives and their evaluation for anti-inflammatory
and analgesic activities. (2007) - Bioorganic
& Medicinal Chemistry 15, 3334-3344 |
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Tyagi E, Agrawal R, Nath
C and Shukla R - Effect of anti-dementia
drugs on LPS induced neuroinflammation in mice.
(2007) - Life Science 80, 1977-1983 |
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Tyagi E, Awasthi KK, Shakya
N, Shukla R and Saxena AK - Synthesis
and SAR of 1-[(4-arylpiperazin/piperidin-1-yl)-3-quinoloxy-6-yl]
propanes as potent anti-inflammatory agents (2007)
- Med Chem Res 15, 387-389 |
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Shukla, R, Rajani
M, Srivastava N, Barthwal MK & Dikshit M. - Nitrite
and malondialdehyde content in cerebrospinal fluid of
patients with Parkinson’s disease. (2006)
- International J Neuroscience , 116, 1391-402.
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Banerjee M, Tripathi LM,
Srivastava VML, Puri A, and Shukla R:
Modulation of inflammatory mediators by ibuprofen and
curcumin treatment during chronic inflammation in rat.
Immunopharmacology and Immunotoxicology, 25,
213-224, 2003. |
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KarChowdhury
D, Parmar D, Kakkar P, Shukla R, Seth
PK, Srimal RC: Antistress effects of Bacosides of Bacopa
monnieri: Modulation of HSP-70 expression, superoxide
dismutase (SOD) and cytochrome P450 activity in rat brain.
Phytotherapie Res 16, 639-645, 2002.
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Hegde, LG,
Shukla, R; Srimal, RC and Dikshit, M: Attenuation
in rat brain nitric oxide synthase activity in the coarctation
model of hypertension. Pharmacological Research
36, 109-114, 1997. |
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Shukla,
R; Srimal RC and Prasad, C: Cyclo(His-Pro) modulation
of body temperature at hot ambient temperature in the
desert rat (Mastomys natalensis). Peptides 18,
689-694, 1997. |
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Agrawal, A;
Shukla, R; Tripathi, LM; Pandey, VC and
Srimal, RC: Permeability function related to cerebral
microvessel enzymes during ageing in rats. Int
J Devl Neuroscience 14, 87-91, 1996.
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