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DR. RANJANA SRIVASTAVA |
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Scientist G
& Scientist- in- Charge
Microbiology
Division
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| AREA OF RESEARCH SPECIALIZATION |
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Micobial and Molecular Genetics, vaccine
research, Biotechnology
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| PRESENT AREA OF ACTIVITY |
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Pathogenesis of Virulence Factors of Cholera Bacteria
and Biology of Latent Mycobacteria |
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| SELECTED
PUBLICATIONS |
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V. Srivastava, A. Jain,
B.S. Srivastava BS and R. Srivastava. 2008.Selection
of genes of Mycobacterium tuberculosis upregulated during
residence in lungs of infected mice.Tuberculosis
(Edinb).88, 171. |
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Mohammad Saquib,
Manish K. Gupta, Ram Sagar, Yenamandra S. Prabhakar ,
Arun K. Shaw, Rishi Kumar, Prakash R. Maulik, Anil Gaikwad,
Sudhir Sinha, Anil K. Srivastava, Vinita Chaturvedi, Ranjana
Srivastava and Brahm S. Srivastava. 2007.
C-3 Alkyl /Arylalkyl-2,3-dideoxy hex-2-enopyranosides
as antitubercular agents: Synthesis, Biological Evaluation
and QSAR study. J. Med. Chem., 2007,
50, 2942. |
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V. Srivastava,
C. Rouanet, R. Srivastava, B. Ramalingam,
C. Locht and B.S. Srivastava. 2007. Macrophage
specific M. tuberculosis genes identified by green fluorescent
protein and kanamycin resistance selection. Microbiology
153 (Pt 3) 659-66. 48. |
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P. Akhtar,
S. Srivastava, Anil Srivastava, Mukesh Srivastava, Brahm
S. Srivastava, Ranjana Srivastava 2006.
Rv3303c of Mycobacterium tuberculosis protects tubercle
bacilli against oxidative stress in vivo and contributes
to virulence in mice. Microbes and infection
8, 2855. |
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Ravi K. Asthana,,
Arunima Srivastava, Akhilesh P. Singh, Deepali, Sureshwar
P. Singh, Gopal Nath, Ranjana Srivastava and
Brahm S. Srivastava. 2006. Identification
of an antimicrobial entity from the cyanobacterium Fischerella
sp. isolated from bark of Azadirachta indica (Neem) tree
. J. Applied Phycology 18 (1), 33. |
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Ranjana
Srivastava, D. Kumar, M.N. Waskar, M. Sharma,
V.M. Katoch and B.S. Srivastava. 2006.
Identification of a repetitive sequence belonging to a
PPE gene of Mycobacterium tuberculosis and its use in
diagnosis of tuberculosis . J. Med. Microbiol.
55, 1071. |
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Synthesis
and antitubercular activities of bis-glycosylated diamino
alcohols. R.P. Tripathi, V. K. Tiwari, N. Tewari, D. Katiyar,
N. Saxena, S. Sinha, A. Gaikwad, A. K. Srivastava, V.
Chaturvedi, Y. K. Manju, R. Srivastava,
B. S. Srivastava. 2005. Bioorg Med Chem.
13, 5668. |
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R.P.S. Parti,
S. Srivastava, R. Gachhui, K.K. Srivastava, Ranjana Srivastava.
2005. Murine infection model for Mycobacterium fortuitum.
Microbes and Infection. 7, 349 |
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M. Zampini, C. Pruzzo,
V.P. Bondre, R. Tarsi, M. Cosmo, A. Bacciaglia, A. Chabbra,
R. Srivastava, B.S. Srivastava..
2005. Vibrio cholerae persistence in aquatic
environments and colonization of intestinal cells: involvement
of a common adhesion mechanism. FEMS Microbiol.
Lett. 244 , 267. |
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D. Katiyar, V.K. Tiwari,
N. Tiwari, S.S. Verma, S. Sinha, A. Gaikwad, A. Srivastava,
V., Chaturvedi, R. Srivastava, B.S. Srivastava
and R.P. Tripathi 2005. Synthesis of
antimycobacterial activity of Glosylated Aminesand Amino
Alcohols.. Eur. J. Med. Chem.40, 351. |
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Synthesis of Galactopyranosyl
Amino Alcohols as a new class of Antitubercular and antifungal
agents. 2004. N. Tewari, V. K. Tiwari,
R. P. Tripathi, A. Gaikwad, S. Sinha, P. K. Shukla, R.
Srivastava and B. S. Srivastava, Bio.
Med. Chem.Lett. 12, 329. |
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Gautam Panda, Shagufta
, Jitendra Kumar Mishra, Vinita Chaturvedi, Anil K. Srivastava,
Ranjana Srivastava and Brahm S. Srivastava
2004. Diaryloxy methano phenanthrenes: a new
class of antituberculosis agents..Biorg. Med.
Chem. 12 . 5269. |
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P. Prem Raj, S. Srivastava,
S. K. Jain, B. S. Srivastava, R. Srivastava..
2003. Protection by live Mycobacterium habana
cvaccine against Mycobacterium tuberculosis H37Rv challenge
in mice. Indian J. Med. Res. 117, 139. |
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A. Mishra, A., R.
Srivastava, C. Pruzzo, B.S. Srivastava. 2003.
Mutation in tcpR gene (Vc0832) of Vibrio cholerae O1 causes
loss of tolerance to high osmolarity and affects colonization
and virulence in infant mice. J. Med. Microbiol.
52, 1. |
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D. Katiyar, V.K. Tiwari,
R.P. Tripathi, A. Srivastava, V. Chaturvedi, R.
Srivastava. 2003. Synthesis
an antimycobacterial activity of 3,5-disubstituted thiadiazine
thiones. Bioorg. Med. Chem. 11, 4369.
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D.K. Deb, P. Dahiya, K.K.
Srivastava, R. Srivastava. B.S. Srivastava.
2002. Selective identification of new therapeutic targets
of Mycobacterium tuberculosis by IVIAT approach. Tuberculosis
82, 175. |
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R.P. Tripathi, R. Tripathi,
V.K. Tiwari, L. Bala, S. Sinha, S.A. Srivastava, R.
Srivastava, B.S. Sivastava. 2002.
Synthesis of Glycosylated ?-amino acids as new class of
antitubercular agents. Eur. J. Med. Chem
, 2002, 37, 773. |
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Rashmi Pathak, A. K. Shaw,
A. P. Bhaduri, K. V. G. Chandrasekhar, A. Srivastava,
K. K. Srivastava, V. Chaturvedi, Ranjana Srivastava,
Brahm S. Srivastava, S. Arora and S. Sinha. 2002.
Higher acyclic nitrogen containing deoxy sugar derivatives:
a new lead in the generation of antimycobacterial chemotherapeutics.
Biorg. Med. Chem. 10, 1695 |
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Rashmi Pathak, C. S. Pant,
Arun K. Shaw, A. P. Bhaduri, A. N. Gaikwad, S. Sinha,
A. Srivastava, K. K. Srivastava, V. Chaturvedi, Ranjana
Srivastava and Brahm S. Srivastava. 2002.
Baylis-Hillman Reaction: Convenient ascending syntheses
and biological evaluation of Acyclic Deoxy monosaccharides
as potential antimycobacterial agents. Biorg.
Med. Chem. 10, 3187. |
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D.K. Deb, K. K. Srivastava,
R. Srivastava, R. B.S. Srivastava. 2000.
Bioluminescent Mycobacterium aurum expressing firefly
luciferase for rapid and high throughput screening of
antimycobacterial drugs in vitro and in infected macrophages.
Biochem. Biophys. Res. Comm. 279, 457.
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R. Srivastava,
B.S.. 2000. Tuberculosis vaccines: a
critical role for T-cells. Curr. Opinion Anti-inflammatory
& Immunomodulatory Investigational Drugs 2
(2), 100. |
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M. Waskar, D. Kumar, A.
Kumar, R. Srivastava. 2000. Isolation
of a novel insertion sequence from Mycobacterium fortuitum
using a trap vector based on inactivation of a lacZ reporter
gene. Microbiology, 146, 1157. |
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R. Srivastava,
B.S. Srivastava. 2000. Tuberculosis vaccines.
IDrugs, 3, 408. |
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R. Srivastava,
D.K. Deb, K.K. Srivastava, C. Locht, B. S. Srivastava.
1998. Green fluorescent protein as a
reporter in rapid screening of antituberculosis compounds
in vitro and in macrophages. Biochem. Biophys.
Res. Commun.. 253, 431. |
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D. Kumar, B.S. Srivastava,
R. Srivastava. 1998. Genetic rearrangements
leading to disruption of heterologous gene expression
in mycobacteria: An observation with ?-galactosidase in
Mycobacterium smegmatis. Vaccine, 16,
1212. |
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A. Shukla, M.P. Dubey,
R. Srivastava, B.S. Srivastava .1998.
Differential expression of proteins during healing of
cutaneous wounds in experimental and normal and chronic
models. Biochem. Biophys. Res. Commun.
244, 434. |
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V.P. Bondre, R.
Srivastava, V.B. Sinha, B.S. Srivastava.
1997. Screening of TnphoA mutants of Vibrio cholerae
0139 for identification of antigens involved in colonization.
J. Med. Microbiol. 46, 1007. |
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R. Srivastava,
D. Kumar, B. S. Srivastava.1997. Recombinant
Mycobacterium aurum expressing Escherichia coli ?-galactosidase
in high through put screening of antituberculosis drugs.
Biochem. Biophys. Res. Commun. 240, 536.
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R. Srivastava,
D. Kumar, P Subramaniam, B.S. Srivastava. 1997.
alpha- galactosidase reporter system in mycobacteria and
its application in rapid antimycobacterial drug screening.
Biochem. Biophys. Res. Commun. 235, 602. |
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D. Kumar, R. Srivastava,
B. S. Srivastava.1995. Epidemiology of
tuberculosis by molecular tools. Proc. Natl. Acad.
Sci., India, 65 (B), II, 113. |
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D. Kumar, B.S. Srivastava,
N. B. Singh, R. Srivastava. 1996.
Identification of a 25 kDa protein of Mycobacterium bovis
BCG to distinguish BCG from Mycobacterium tuberculosis.
J. Clin. Microbiol. 34, 224. |
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R. Srivastava,
G. Prasanna Kumar, K.K. Srivastava. 1995.
Genetic construction of a cellulolytic Escherichia coli.
Gene 164, 185. |
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S.N. Singh, R.
Srivastava, V.B. Sinha, B.S. Srivastava.
1994. A 53 kDa protein of Vibrio cholerae classical
strain 0395 involved in intestinal colonization. Microbial
Pathogenesis 17, 69. |
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K. Krishna Kumar,
R, Srivastava, V.B. Sinha, J. Mechalski, J.B.
Kaper, B.S.Srivastava. 1994. recA mutations
reduce adherence and colonization of classical and el
tor strains of Vibrio cholerae. Microbiology
140, 1217. |
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R. Srivastava,
A.K. Srivastava. 1993. Characterization
of a bacterial xylanase resistant to repression by glucose
and xylose. Biotech. Lett. 15, 847. |
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V.B. Sinha, A. Jacob,
R. Srivastava ,J.B. Kaper, B.S. Srivastava.
1993. Identification of the flagellar antigens
of Vibrio cholerae el tor and their role in protection.
Vaccine, 11, 372A. |
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A. Jacob, V.B. Sinha,
R. Srivastava, M.K. Sahib, J.B. Kaper, B.S. Srivastava.
1993. Identification of a 33 kDa antigen
associated with an adhesive and colonizing strain of Vibrio
cholerae el tor and its role in protection. Vaccine,
11, 376. |
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C.K.M. Tripathi, S.S.
Ali, R. Srivastava. 1992. Characterization
of xylanase activity of Streptomyces wedmorensis. Ind.
J. Exptl. Biol. 30, 741. |
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R. Srivastava,
S. S. Ali, B.S. Srivastava. 1991. Cloning
of xylanase gene of Streptomyces flavogriseus in Escherichia
coli and bacteriophage lambda induced lysis for the release
of cloned enzyme. FEMS Microbiol Lett.
78, 201. |
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R. Srivastava,
R. Bharti, A.K. Srivastava. 1990. Characterization
of a novel cellobiase from Bacillus subtilis and expression
of its structural gene in Escherichia coli. Biotech.
Lett. 12, 541. |
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A.W. Kerrebroeck, R.
Srivastava, S.A. Gerbi. 1989.
Isolation and characterization of ribosomal DNA variants
from Sciara coprophila. J. Mol. Biol.
210, 1. |
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R. Srivastava,
V.B. Sinha, B.S. Srivastava 1989 . Chromosomal;
transfer and in vivo cloning of genes in Vibrio cholerae
using RP4::mini-Mu. Gene 75, 253. |
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