|
| |
|
Rituraj Konwar |
|
| |
 |
.. |
Scientist C
Endocrinology
Central Drug Research Institute,
Lucknow-226 001 |
| |
| Educational Qualifications |
B.V.Sc. & A.H., M.
V. Sc. (Biotech), PhD (IVRI, Izatnagar) |
| Phone |
+91-522-2612411-18 Ext.
4306 |
| E-Mail |
r_konwar@cdri.res.in |
| Date of Birth |
23.10.1975 |
|
| |
| RESEARCH
EXPERIENCE |
| |
|
•
|
Molecular
Endocrinology and Breast Cancer |
| |
| CURRENT
AREAS OF INTEREST |
| |
|
•
|
Development
of novel therapeutic molecules against breast cancer:
We are actively involved in characterizing new entity
of synthetic/natural source against both ER-positive proliferative
as well as ER-negative metastatic breast cancer. Current
project involves extensive in vitro screening of new compounds
in a panel of breast carcinoma cell lines including MCF-7,
MDA-MB-231. We employ DMBA-induced mammary tumor model
for in vivo efficacy testing of promising lead molecules.
We are also involved in candidate gene polymorphism studies
in breast cancer and benign prostatic hyperplasia. |
|
|
| SELECTED
PUBLICATIONS |
| |
• |
Konwar R,
Chaudhary P, Kumar S, Mishra D, Chattopadhyay N, Bid HK.
Breast cancer risk associated with polymorphisms of IL-1RN
and IL-4 gene in Indian women. Oncol Res. 2009;17(8):367-72. |
• |
Reddy KP, Bid HK, Nayak
VL, Chaudhary P, Chaturvedi JP, Arya KR, Konwar
R, Narender T. In vitro and in vivo anticancer
activity of 2-deacetoxytaxinine J and synthesis of novel
taxoids and their in vitro anticancer activity.
Eur J Med Chem. 2009 Apr 22 |
• |
Shankar R, Chakravarti
B, Singh US, Ansari MI, Deshpande S, Dwivedi SK, Bid HK,
Konwar R, Kharkwal G, Chandra V, Dwivedi
A, Hajela K. Synthesis and biological evaluation of 3,4,6-triaryl-2-pyranones
as a potential new class of anti-breast cancer agents.
Bioorg Med Chem. 2009 Jun 1;17(11):3847-56.
|
• |
Konwar R,
Gara R, Singh M, Singh V, Chattopadhyay N, Bid HK. Association
of interleukin-4 and interleukin-1 receptor antagonist
gene polymorphisms and risk of benign prostatic hyperplasia.
Urology. 2008 May;71(5):868-72. |
• |
Konwar R,
Chattopadhyay N, Bid HK. Genetic polymorphism and pathogenesis
of benign prostatic hyperplasia. BJU Int. 2008
Aug 5;102(5):536-44. |
• |
Hemant Kumar Bid,
Rituraj Konwar, CG Agrawal, Monisha Banerjee.
(2008) Association of IL-4 and IL-1RN
(receptor antagonist) gene variants and the risk of type
2 diabetes mellitus: A study in the north Indian population.
Indian J Med Sci. Jul; 62(7):259-66. |
| • |
Prem P. Yadav,
Ashish Arora, Hemant K. Bid, Rituraj Konwar
and Sanjeev Kanojiya (2007) New cassane
butenolide hemiketal diterpenes from the marine creeper
Caesalpinia bonduc and their antiproliferative activity.
Tetrahedron Letters 48:40, Pages 7194-7198. |
| • |
Koneni V.
Sashidhara, J Naga Rosaiah, A Kumar, Hemant K Bid, Rituraj
Konwar, Naibedya Chattopadhyay (2007)
Cell growth inhibitory action of an unusual labdane diterpene,
13-epi-sclareol in breast and uterine cancers in vitro.
Phytotherapy Research, 18;21(11):1105-1108.
|
| |
| |
|
|
| |
|
| |
|