Dr. R K Sharma
 

Scientist “G” & Head
Division of Botany
Central Drug Research Institute
Lucknow- 226 001 (U.P.), India
 
Phone No. +91-522-2612411 ext. 4229
Fax +91-522-2623405
E-Mail rk_sharma@cdri.res.in rkscdri@gmail.com
Educational qualifications M. Sc., Ph. D. (Botany)
Date of Birth 04.01.1951
 
CURRENT AREAS OF RESEARCH EXPERIENCE
 
Bioinformatics applications
Design & development of databases
Design & development of database management systems [DBMS]
Medicinal plants & their uses.
Information Security
Information Technology and its applications
 
We work very close to nature and contribute to the drug development program of the institute very significantly by conducting surveys, collecting, authenticating, documenting and distributing the terrestrial and marine biota materials/samples for biological screening. Efforts are being made to strengthen the plant sample processing facility in the division as well as initating some R&D in bioinformatics, . Very recently we have expanded our areas of activities in this division and initiated 1). Digital Herbarium 2). Marine & terrestrial plant bioinformatics facility 3). Plant tissue culture facility, 4.Plant genomic facility. 5. Plant sample collection & processing facility. Efforts are being made to submit research project in each of the areas.

The Digital Herbarium : A herbarium is a collection of preserved plant specimens. These specimens may be whole plants or plant parts: these will usually be in a dried form, mounted on a sheet, but depending upon the material may also be kept in alcohol or other preservative. The specimens in a herbarium are often used as reference material in describing plant taxa; some specimens may be types. In botany a type is that which fixes a name to a taxon

We have a priced collection of world recognized Herbarium on Indian Medicinal Plants, with a name “CDRI Herbarium”.Web reference of the herbarium http://www.biodiversitycollectionsindex.org/collection/view/id/12764. We have initiated the process of digitization, which will help us in minimizing the damage to the herbarium sheets in our collection as well as help us to make the herbarium as a WEB Enabled. Virtual Herbarium for global access. Efforts are being made to design & develop an integrated software system to manage the taxonomic, collection, DNA, DNA sequence and the image data sets related to the herbarium.. At a later stage this database could be linked to the CDRI natural products screening database and folk lore uses database and Compendium database.

Marine & terrestrial plant bioinformatics facility: Bioinformatics in drug development domain can be defined as a scientific discipline which integrates, IT, computer science, statistic, mathematics, bio-physics, chemistry for organizing, storing, retrieving, analyzing, interpreting, predicting biological sciences data for a better understanding of various biological systems and for drug development oriented research & development purposes. Thus Bioinformatics derives knowledge from computer analysis of biological data. These can consist of the information stored in the genetic code, but also experimental results from various sources, patient statistics, and scientific literature. Research in bioinformatics includes method development for storage, retrieval, and analysis of the data. Bioinformatics is a rapidly developing branch of biology and is highly interdisciplinary, using techniques and concepts from informatics, statistics, mathematics, chemistry, biochemistry, physics, and linguistics. It has many practical applications in different areas of biology and medicine. In botany application of bioinformatics can also help in predicting the medicinal values of the respective plants and predict candidate drug, Additionally we can do phylogenetic studies on different taxa.
This facility is being strengthened. When fully equipped, we will be able to predict the medicinal properties of the plants in our herbarium. As of now we have trained 6 M.Tech/MSc Bioinformatics/Biotechnology students under this facility.

The Plant Tissue culture facility is being created to raise tissue culture of plant samples –from rare species/endangered species, or from bark and stem. In future we would like to have a gene bank of medicinal plants of India

The Plant Genomic facility: This facility will provide wet lab inputs to the Bioinformatics facility as well as help in identification & authentication of bioactive constituents. Through the biochemical/functional studies on plant proteins we will be able to provide inputs to drug designing, candidate drugs/ligand for various drug targets as well as inputs to other disciplines in the institute.

The Plant sample collection & processing facility: For temperature controlled drying and grinding of fresh & dry plant material collected from all over the country
 
Members Scientific Bodies
 

Member, Central Council of Research in Homeopathy, New Delhi

Member, Editorial Board “Ocean Drugs Alert” (2006-2007), CDRI, Lucknow
Member, Computer Society of India, Chennai
Member, Indian Society Of Authors, New Delhi
Member, Association of Knowledge Workers, Lucknow
Member, Akwl- Knowledge Center For Promotion of Bio Science and Agri Business, Lucknow
Member, Indian Society of Plant Pathologists, New Delhi
 
Some Recent Research Publications [invited review articles/lectures and research papers] :
 
N. N. Mehrotra, S. Tandon and R. K. Sharma(1989). “Innovations in Biotechnology, Indian Patent Act and Industrial Development”. National Conference Of Scientists On SCIENCE TECHNOLOGY AND PATENTS, 4th December 1989, at New Delhi.
S. S. Iyer, M. Jinandra Doss, A. K. Srivastava and R. K. Sharma (1990). “Establishment of Lucknow Special Libraries Network (LUCKSLIBNET)”. National Symposium On “COMPUTER COMMUNICATIONS”, 11th -12th April 1990 at CSIO, Chandigarh
R. K. Sharma, A. K. Goel, N.N. Mehrotra, J.A. Zaidi & B.N.Dhawan. (1991) “Natural Products Database : Dvelopments & Future Plans at CDRI”. Workshop on Design & Management of a Computerised Database on Indian Medicinal Plants, 28-31 May 1991 at Coimbatore..
R. K. Sharma (1991). “Future of Factual Databases & Drug Research at CDRI”. International Workshop of FACTUAL DATABASE EXPERTS, organised by UNESCO & Dep. of Science Technology, New Delhi 1993, at New Delhi.
O. P. Asthana, R. K. Sharma, S. K. Mandal, R. C. Srimal and B. N. Dhawan (1991). “Baseline Clinical and Laboratory Data on Healthy Human Volunteers participating in Phase-I Clinical Trials” International Workshop on “Teaching of Clinical Pharmacology” with theme “Pharmacology for Rational Drug Therapy” 8th - 9th July, 1991, AIIMS, New Delhi.
R. K. Sharma (1991). “Computers and Data: An Introduction”, Brain Storming Cum Training Session on Molecular Modelling In Drug Research, Sponsored by DBT New Delhi, 12th -13th Dec 1991, at CDRI Lucknow.
R. K. Sharma (1992) “Computerised Database: An approach”. UNESCO-CDRI workshop on “ Use of Pharmacological Techniques for the Study of Natural Products “, 30th March - 4th April, 1992, at CDRI Lucknow
R. K. Sharma, J. A. Zaidi and A. K. Goel (1993). NATTS – “An Integrated Factual Database on Indian Medicinal Plants” .Proceedings INFOTEX ‘93, Database Production and Distribution:Resources, Technology and Management, Edtors N. Seshgiri, I. K. Ravichandra Rao and Satyanarayana, pp. 303-312, 1993.
R. K. Sharma (1994). “Databases and Their Role in Drug Research at CDRI”. Workshop / Consultative Meeting of Experts for Phytochemistry & Pharmacology Database Structure, 21-22 January 1994 at CDRI, Lucknow.
R. K. Sharma, A. K. Srivastava & J. A. Zaidi. (1999).” A Modular Library Automation Solution for Next Millennium”. Convention of the Heads of CSIR Libraries & Information Centres,May 13-15, 1999, at NBRI, Lucknow.
P.K. Murthy and R.K. Sharma (2005), “Changing paradigm of filarial perspectives” in Infectious diseases of domestic animals and zoonoses in India edts V Tandon & BN Dhawan, Proc. Nat Acad. Sci. India, 75(B) Special Issue, 2005:205-228.
G. Sharma ,D Tripathi, D Awasthi & R.K.Sharma (2006). ICT & Healthcare: For Better Networked Governance, in NRC-2006: Paradigm shift throughe-Governance At Hotel Taj Residency, Lucknow, 4-5 March 2006.
M Abbas & RK Sharma (2006) Information Resources & Tools For Kinetics Simulation Of Biochemical Pathways IEI-All India Conference
RK Sharma (2006) New Technologies (Nano & Bio): Drug Development & Delivery All India seminar on Frontier areas of Chemical Engineering: Statigies for Future Organised by Institution of Engineers(India) 18-19th March, 2006
RK Sharma (2006).Paradigm shift in Approaches for drug development: Multivariate Bioinformatics Domain in Pre Conference Workshop International Conference on Multivariate Statistical Methods, 28-29 December 2006 at ISI, Kolkata,
RK Sharma (2006).CASE Analytical & Visualization Tools in Multivariate Bioinformatics in Pre Conference Workshop International Conference on Multivariate Statistical Methods, 28-29 December 2006 at ISI, Kolkata
RK Sharma (2006).Mutivariate Statistical Analysis: Case Studies in Bioinformatics Domain, in Pre Conference Workshop International Conference on Multivariate Statistical Methods, 28-29 December 2006 at ISI, Kolkata
RK Sharma (2006).Emerging Technologies: Current Trends in Nanotechnology and Biotechnology (Inaugural Lecture ) during the National Seminar on “Emerging Computer technologies” 4-6th December 2006” at IEI, Lucknow.
RK Sharma (2006).Bioinformatics: Genome Domain: Inaugural Lecture, during the National workshop on “Exploring Genomes with Bioinformatics” from 22-23 February, 2006 at BTIS Sub Centre, Biotechnology Department, Aligarh Muslim University, Aligarh.
RK Sharma (2006). Web Technology & Tools: Genomicc Web Resources during the National Workshop on “Genomics: Databases and Web Technologies ”, 18-20 May 2006, organized by Biotech Park, Lucknow..
RK Sharma (2006). Database design concepts & Tools during the National Workshop on “Tools and Languages for database development ”, from 9-10 Nov, 2006. organized by Biotech Park, Lucknow.
RK Sharma & M Abbas, (2007). Information Security and Patch Management during the All India Seminar on “Cyber Crime & Security Challenges”, 13-15 April 2007 organised by IEI,Lucknow
M Abbas & RK Sharma (2007). Protection of organizations sensitive information against insider attacks during the All India Seminar on “Cyber Crime & Security Challenges”, 13-15 April 2007 organised by IEI,Lucknow.
RK Sharma (2007).Genome Analysis: Tools, Technologies and Case studies. National workshop on “Genome Analysis: A bioinformatics Approach”, from 24-25 February, 2007 at BTIS Distributed Information Centre, Aligarh Muslim University, Aligarh.
RK Sharma (2007).Genome Analysis: Statistical & Visualisation Tools. National workshop on “Genome Analysis: A bioinformatics Approach”, from 24-25 February, 2007 at BTIS Distributed Information Syb Centre, Aligarh Muslim University, Aligarh.
RK Sharma (2007).Genome-Phylogenetics and Sequence Alignment. National workshop on “Genome Analysis: A bioinformatics Approach”, from 24-25 February, 2007 at BTIS Distributed Information Syb Centre, Aligarh Muslim University, Aligarh
RK Sharma (2007).Protein Structure Prediction. National workshop on “Genome Analysis: A bioinformatics Approach”, from 24-25 February, 2007 at BTIS Distributed Information Sub Centre, Aligarh Muslim University, Aligarh.
Luv Kashyap and Ravi Kumar Sharma (2007).Alternative splicing: a paradoxical qudo in eukaryotic genome, Bioinformation, 2(4): 155-156 (2007). http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2255073
Tadigoppula Narendera, Tanvir Khaliqa, Shwetaa, Kancharla P. Reddya and Ravi K. Sharma (2007) Occurrence, Biosynthesis, Biological activity and NMR, Spectroscopy of D and B, D Ring Seco-limonoids of Meliaceae Family#, Natural Product Communications 2 (2), 203 – 221
R.K. Sharma (2009). Omics & drug development AMU2009
R.K. Sharma (2009). Conformational Analysis and Molecular Modelling of Novel Bioactive Molecules
R.K. Sharma (2008). Information & Communication Technologies And Drug Research,15-9-2008
R.K. Sharma (2009). Bioinformatics & Drug Development: Tools, Techgnologies, Opportunities & case studies at Faizabad Agric Uni6-1-2009