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| Dr.
R K Sharma |
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Scientist “G” & Head
Division of Botany
Central Drug Research Institute
Lucknow- 226 001 (U.P.), India
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| CURRENT
AREAS OF RESEARCH EXPERIENCE |
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Bioinformatics
applications |
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Design & development
of databases |
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Design & development
of database management systems [DBMS] |
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Medicinal plants &
their uses. |
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Information Security |
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Information Technology
and its applications |
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We work very close to nature
and contribute to the drug development program of the institute
very significantly by conducting surveys, collecting, authenticating,
documenting and distributing the terrestrial and marine biota
materials/samples for biological screening. Efforts are being
made to strengthen the plant sample processing facility in
the division as well as initating some R&D in bioinformatics,
. Very recently we have expanded our areas of activities in
this division and initiated 1). Digital Herbarium 2). Marine
& terrestrial plant bioinformatics facility 3). Plant
tissue culture facility, 4.Plant genomic facility. 5. Plant
sample collection & processing facility. Efforts are being
made to submit research project in each of the areas.
The Digital Herbarium : A herbarium is a
collection of preserved plant specimens. These specimens may
be whole plants or plant parts: these will usually be in a
dried form, mounted on a sheet, but depending upon the material
may also be kept in alcohol or other preservative. The specimens
in a herbarium are often used as reference material in describing
plant taxa; some specimens may be types. In botany a type
is that which fixes a name to a taxon
We have a priced collection of world recognized Herbarium
on Indian Medicinal Plants, with a name “CDRI Herbarium”.Web
reference of the herbarium http://www.biodiversitycollectionsindex.org/collection/view/id/12764.
We have initiated the process of digitization, which will
help us in minimizing the damage to the herbarium sheets in
our collection as well as help us to make the herbarium as
a WEB Enabled. Virtual Herbarium for global access. Efforts
are being made to design & develop an integrated software
system to manage the taxonomic, collection, DNA, DNA sequence
and the image data sets related to the herbarium.. At a later
stage this database could be linked to the CDRI natural products
screening database and folk lore uses database and Compendium
database.
Marine & terrestrial plant bioinformatics facility:
Bioinformatics in drug development domain can be defined as
a scientific discipline which integrates, IT, computer science,
statistic, mathematics, bio-physics, chemistry for organizing,
storing, retrieving, analyzing, interpreting, predicting biological
sciences data for a better understanding of various biological
systems and for drug development oriented research & development
purposes. Thus Bioinformatics derives knowledge from computer
analysis of biological data. These can consist of the information
stored in the genetic code, but also experimental results
from various sources, patient statistics, and scientific literature.
Research in bioinformatics includes method development for
storage, retrieval, and analysis of the data. Bioinformatics
is a rapidly developing branch of biology and is highly interdisciplinary,
using techniques and concepts from informatics, statistics,
mathematics, chemistry, biochemistry, physics, and linguistics.
It has many practical applications in different areas of biology
and medicine. In botany application of bioinformatics can
also help in predicting the medicinal values of the respective
plants and predict candidate drug, Additionally we can do
phylogenetic studies on different taxa.
This facility is being strengthened. When fully equipped,
we will be able to predict the medicinal properties of the
plants in our herbarium. As of now we have trained 6 M.Tech/MSc
Bioinformatics/Biotechnology students under this facility.
The Plant Tissue culture facility is being
created to raise tissue culture of plant samples –from
rare species/endangered species, or from bark and stem. In
future we would like to have a gene bank of medicinal plants
of India
The Plant Genomic facility: This facility
will provide wet lab inputs to the Bioinformatics facility
as well as help in identification & authentication of
bioactive constituents. Through the biochemical/functional
studies on plant proteins we will be able to provide inputs
to drug designing, candidate drugs/ligand for various drug
targets as well as inputs to other disciplines in the institute.
The Plant sample collection & processing facility:
For temperature controlled drying and grinding of fresh &
dry plant material collected from all over the country
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| Members
Scientific Bodies |
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Member,
Central Council of Research in Homeopathy, New Delhi |
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Member, Editorial Board
“Ocean Drugs Alert” (2006-2007), CDRI, Lucknow |
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Member, Computer Society
of India, Chennai |
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Member, Indian Society
Of Authors, New Delhi |
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Member, Association of
Knowledge Workers, Lucknow |
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Member, Akwl- Knowledge
Center For Promotion of Bio Science and Agri Business,
Lucknow |
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Member, Indian Society
of Plant Pathologists, New Delhi |
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| Some
Recent Research Publications [invited review articles/lectures
and research papers] : |
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N. N. Mehrotra,
S. Tandon and R. K. Sharma(1989).
“Innovations in Biotechnology, Indian Patent Act
and Industrial Development”. National Conference
Of Scientists On SCIENCE TECHNOLOGY AND PATENTS, 4th December
1989, at New Delhi. |
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S. S. Iyer,
M. Jinandra Doss, A. K. Srivastava and R. K. Sharma
(1990). “Establishment of Lucknow
Special Libraries Network (LUCKSLIBNET)”. National
Symposium On “COMPUTER COMMUNICATIONS”, 11th
-12th April 1990 at CSIO, Chandigarh |
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R.
K. Sharma, A. K. Goel, N.N. Mehrotra, J.A. Zaidi
& B.N.Dhawan. (1991) “Natural
Products Database : Dvelopments & Future Plans at
CDRI”. Workshop on Design & Management of a
Computerised Database on Indian Medicinal Plants, 28-31
May 1991 at Coimbatore.. |
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R. K. Sharma (1991).
“Future of Factual Databases & Drug Research
at CDRI”. International Workshop of FACTUAL DATABASE
EXPERTS, organised by UNESCO & Dep. of Science Technology,
New Delhi 1993, at New Delhi. |
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O. P. Asthana, R.
K. Sharma, S. K. Mandal, R. C. Srimal and B.
N. Dhawan (1991). “Baseline Clinical
and Laboratory Data on Healthy Human Volunteers participating
in Phase-I Clinical Trials” International Workshop
on “Teaching of Clinical Pharmacology” with
theme “Pharmacology for Rational Drug Therapy”
8th - 9th July, 1991, AIIMS, New Delhi. |
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R. K. Sharma (1991).
“Computers and Data: An Introduction”, Brain
Storming Cum Training Session on Molecular Modelling In
Drug Research, Sponsored by DBT New Delhi, 12th -13th
Dec 1991, at CDRI Lucknow. |
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R. K. Sharma (1992)
“Computerised Database: An approach”. UNESCO-CDRI
workshop on “ Use of Pharmacological Techniques
for the Study of Natural Products “, 30th March
- 4th April, 1992, at CDRI Lucknow |
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R. K. Sharma,
J. A. Zaidi and A. K. Goel (1993). NATTS
– “An Integrated Factual Database on Indian
Medicinal Plants” .Proceedings INFOTEX ‘93,
Database Production and Distribution:Resources, Technology
and Management, Edtors N. Seshgiri, I. K. Ravichandra
Rao and Satyanarayana, pp. 303-312, 1993. |
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R. K. Sharma (1994).
“Databases and Their Role in Drug Research at CDRI”.
Workshop / Consultative Meeting of Experts for Phytochemistry
& Pharmacology Database Structure, 21-22 January 1994
at CDRI, Lucknow. |
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R. K. Sharma,
A. K. Srivastava & J. A. Zaidi. (1999).”
A Modular Library Automation Solution for Next Millennium”.
Convention of the Heads of CSIR Libraries & Information
Centres,May 13-15, 1999, at NBRI, Lucknow. |
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P.K. Murthy and R.K.
Sharma (2005), “Changing paradigm of filarial
perspectives” in Infectious diseases of domestic
animals and zoonoses in India edts V Tandon & BN Dhawan,
Proc. Nat Acad. Sci. India, 75(B) Special Issue, 2005:205-228. |
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G. Sharma ,D Tripathi,
D Awasthi & R.K.Sharma (2006). ICT
& Healthcare: For Better Networked Governance, in
NRC-2006: Paradigm shift throughe-Governance At Hotel
Taj Residency, Lucknow, 4-5 March 2006. |
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M Abbas & RK
Sharma (2006) Information Resources & Tools
For Kinetics Simulation Of Biochemical Pathways IEI-All
India Conference |
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RK Sharma (2006)
New Technologies (Nano & Bio): Drug Development &
Delivery All India seminar on Frontier areas of Chemical
Engineering: Statigies for Future Organised by Institution
of Engineers(India) 18-19th March, 2006 |
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RK Sharma (2006).Paradigm
shift in Approaches for drug development: Multivariate
Bioinformatics Domain in Pre Conference Workshop International
Conference on Multivariate Statistical Methods, 28-29
December 2006 at ISI, Kolkata, |
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RK Sharma (2006).CASE
Analytical & Visualization Tools in Multivariate Bioinformatics
in Pre Conference Workshop International Conference on
Multivariate Statistical Methods, 28-29 December 2006
at ISI, Kolkata |
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RK Sharma (2006).Mutivariate
Statistical Analysis: Case Studies in Bioinformatics Domain,
in Pre Conference Workshop International Conference on
Multivariate Statistical Methods, 28-29 December 2006
at ISI, Kolkata |
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RK Sharma (2006).Emerging
Technologies: Current Trends in Nanotechnology and Biotechnology
(Inaugural Lecture ) during the National Seminar on “Emerging
Computer technologies” 4-6th December 2006”
at IEI, Lucknow. |
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RK Sharma (2006).Bioinformatics:
Genome Domain: Inaugural Lecture, during the National
workshop on “Exploring Genomes with Bioinformatics”
from 22-23 February, 2006 at BTIS Sub Centre, Biotechnology
Department, Aligarh Muslim University, Aligarh. |
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RK Sharma (2006).
Web Technology & Tools: Genomicc Web Resources during
the National Workshop on “Genomics: Databases and
Web Technologies ”, 18-20 May 2006, organized by
Biotech Park, Lucknow.. |
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RK Sharma (2006).
Database design concepts & Tools during the National
Workshop on “Tools and Languages for database development
”, from 9-10 Nov, 2006. organized by Biotech Park,
Lucknow. |
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RK Sharma
& M Abbas, (2007). Information Security
and Patch Management during the All India Seminar on “Cyber
Crime & Security Challenges”, 13-15 April 2007
organised by IEI,Lucknow |
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M Abbas & RK
Sharma (2007). Protection of organizations sensitive
information against insider attacks during the All India
Seminar on “Cyber Crime & Security Challenges”,
13-15 April 2007 organised by IEI,Lucknow. |
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RK Sharma (2007).Genome
Analysis: Tools, Technologies and Case studies. National
workshop on “Genome Analysis: A bioinformatics Approach”,
from 24-25 February, 2007 at BTIS Distributed Information
Centre, Aligarh Muslim University, Aligarh. |
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RK Sharma (2007).Genome
Analysis: Statistical & Visualisation Tools. National
workshop on “Genome Analysis: A bioinformatics Approach”,
from 24-25 February, 2007 at BTIS Distributed Information
Syb Centre, Aligarh Muslim University, Aligarh. |
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RK Sharma (2007).Genome-Phylogenetics
and Sequence Alignment. National workshop on “Genome
Analysis: A bioinformatics Approach”, from 24-25
February, 2007 at BTIS Distributed Information Syb Centre,
Aligarh Muslim University, Aligarh |
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RK Sharma (2007).Protein
Structure Prediction. National workshop on “Genome
Analysis: A bioinformatics Approach”, from 24-25
February, 2007 at BTIS Distributed Information Sub Centre,
Aligarh Muslim University, Aligarh. |
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Luv Kashyap and Ravi
Kumar Sharma (2007).Alternative splicing: a paradoxical
qudo in eukaryotic genome, Bioinformation, 2(4): 155-156
(2007). http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2255073 |
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Tadigoppula Narendera,
Tanvir Khaliqa, Shwetaa, Kancharla P. Reddya and Ravi
K. Sharma (2007) Occurrence, Biosynthesis, Biological
activity and NMR, Spectroscopy of D and B, D Ring Seco-limonoids
of Meliaceae Family#, Natural Product Communications 2
(2), 203 – 221 |
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R.K. Sharma (2009).
Omics & drug development AMU2009 |
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R.K. Sharma (2009).
Conformational Analysis and Molecular Modelling of Novel
Bioactive Molecules |
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R.K. Sharma (2008).
Information & Communication Technologies And Drug
Research,15-9-2008 |
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R.K. Sharma (2009).
Bioinformatics & Drug Development: Tools, Techgnologies,
Opportunities & case studies at Faizabad Agric Uni6-1-2009 |
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