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| Dr.
R. P. TRIPATHI |
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Scientist F
Medicinal & Process Chemistry Division
Central Drug Research Institute
Chatter Manzil Palace
P.O.Box No. 173
Lucknow, INDIA |
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| Phone No. |
+91-0522-2212411-18-Ext
4382 |
| Fax No. |
+91-0522-2223405 |
| E- mail |
rp_tripathi@cdri.res.in |
| Educational qualifications |
M.Sc., M.Phil., Ph.D. |
| Date of birth |
December 24th 1956
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| POST
DOCTORAL EXPERIENCE |
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Central Drug
Research Institute, Lucknow, INDIA |
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| RESEARCH
EXPERIENCE |
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| CURRENT
AREAS OF INTEREST |
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Medicinal
Chemistry (antiviral and antitubercular), Bio-Organic
Chemistry, Synthetic Organic Chemistry, Combinatorial
Chemistry. |
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| SELECTED
PUBLICATIONS |
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Bisht SS, Pandey J, Sharma
A and Tripathi RP - Aldol reaction of
beta-C-glycosylic ketones: synthesis of C-(E)-cinnamoyl
glycosylic compounds as precursors for new biologically
active C-glycosides (2008) - Carbohydrate Research
343, 1399-1406 |
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Dube D, Kuashal V, Srivastava
SK, Tripathi RP and Ramachandran R -
NAD(+)-dependent DNA ligase (Rv3014c) from M-tuberculosis:
Strategies for inhibitor design (2008) - Med Chem
Research 17, 189-198 |
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Dwivedi N, Dube D, Pandey
J, Singh BK, Ramachandran R and Tripathi RP
- NAD(+)-dependent DNA ligase: A novel target waiting
for the right inhibitor (2008) - Med Res Rev.
28, 545-568 |
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Kumar Pranav, Kumar Ashutosh,
Verma SS, Dwivedi Namrata, Singh Nasib, Siddiqi Mohammad
Imran, Tripathi RP, Dube Anuradha and
Singh Neeloo - Leishmania donovani pteridine reductase
1: Biochemical properties and structure-modeling studies
(2008) - Experimental Parasitology 120,
73-9 |
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Lal J, Tripathi
RP and Gupta RC - Pharmacokinetics and excretion
of the novel anti-tuberculosis compound 1,2 : 5,6-di-O-isopropylidene-3-O-(phenyl
cyclopropyl methanonyl)-alpha-D-glucofuranose (S-001-14)
after oral doses in rats (2008) - Arzneimittel-Forschung-
Drug Research 58, 410-418 |
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Pandey Jyoti, Mishra Mridul,
Bisht Surendra Singh, Sharma Anindra and Tripathi
Rama P - An efficient chemoselective etherification
of phenols in polyfunctional aromatic compounds (2008)
- Tetrahedron Letters 49, 695-698 |
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Saxena N, Singh N, Mishra
M, Keshava GB, Shukla PK and Tripathi RP
- Synthesis of azatricyclodiones & octahydro-benzo[f]isoindoles
and their antimicrobial evaluation (2008) - Journal
of Enzyme Inhibition and Medicinal Chemistry
23, 476-482 |
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Singh BK, Mishra Mridul,
Saxena Nisha, Yadav GP, Maulik PR, Sahoo MK, Gaur RL,
Murthy PK and Tripathi RP - Synthesis
of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines as a new
class of antifilarial agents (2008) - Eur. J.
Med. Chem. 43, 2717-2723 |
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Singh BK, Yadav AK, Kumar
B, Gaikwad AN, Sinha SK, Chaturvedi V and Tripathi
RP - Preparation and reactions of sugar azides
with alkynes: synthesis of sugar triazoles as antitubercular
agents (2008) - Carbohydrate Research
343, 1153-1162 |
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Singh N, Pandey J and
Tripathi RP - D-Glucosamine, a natural
aminosugar as organocatalyst for an ecofriendly direct
aldol reaction of ketones with aromatic aldehydes in water
(2008) - Catalysis Communications 9,
743-746 |
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Tripathi Rama
P, Verma Shyam S, Pandey Jyoti and Tiwari Vinod
K - Recent development on catalytic reductive amination
and applications (2008) - Current Organic Chemistry
12, 1093-1115 |
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Tripathi RP
, Dwivedi Namrata, Singh Nimisha and Misra Mridul - Synthesis
and antitubercular activity of nucleoside analogs based
on L-ascorbic acid and bases (2008) - Med Chem
Research 17, 53-61 |
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Ahmad R, Srivastava AK,
Tripathi RP, Batra S and Walter RD. - Synthesis
and biological evaluation of potential modulators of malarial
glutathione-S-transferases (2007) - J Enzyme Inhib
Med Chem 22, 327-342 |
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Bisht Surendra S, Dwivedi
Namrata and Tripathi Rama Pati - l-Ascorbic
acid in organic synthesis: a facile synthesis of 4-(butenolide-5-methylidenyl)-1,4-dihydropyridines.
(2007) - Tetrahedron Letters 48, 1187-1189
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Chaturvedi V, Dwivedi
N, Tripathi RP and Sinha S. - Identification
and evaluation of Mycobacterium smegmatis as a possible
surrogate screen for selecting molecules active against
multi-drug resistant Mycobacterium tuberculosis. (2007)
- Journal of General and Applied Microbiology 53,
333-337 |
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Pandey Jyoti, Dwivedi
Namrata, Singh Nimisha, Srivastava AK, Tamarkar A and
Tripathi RP - Diastereoselective synthesis
of glycosylated prolines as a-glucosidase inhibitors and
organocatalyst in asymmetric aldol reaction. (2007)
- Bioorganic & Medicinal Chemistry Letters
17, 1321-1325 |
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Yadav Amit K, Singh Biswajit
K, Singh Nimisha and Tripathi Rama P -
An elegant and unprecedented approach to 2-methylbenzofurans.
(2007) - Tetrahedron Letters 48, 6628-6632
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Dwivedi, Namrata; Bisht,
Surendra S; Tripathi, Rama P - Asymmetric
organocatalysis with glycosyl-beta-amino acids: direct
asymmetric aldol reaction of acetone with aldehydes (2006)
- Carbohydrate Research, 341, 2737-2743 |
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Singh, Biswajit K, Bisht
Surendra Singh & Tripathi Rama P.
- An efficient synthesis of tetramic acid derivatives
with extended conjugation from L-Ascorbic acid (2006)
- Beilstein J Organic Chemistry, 2, 24. |
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Singh, Biswajit K., Verma,
Shyam S., Dwivedi, Namrata and Tripathi, Rama
P. - l-Ascorbic acid in organic synthesis: DBU-catalysed
one-pot synthesis of tetramic acid derivatives from 5,6-O-isopropylidene
ascorbic acid (2006) - Tetrahedron Letters,
47, 2219-2222. |
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Tripathi, R P;
Saxena, Nisha; Tiwari, V K; Verma, S S; Chaturvedi, Vinita;
Manju, Y K; Srivastva, A K; Gaikwad, A; Sinha, S - Synthesis
and antitubercular activity of substituted phenylmethyl-
and pyridylmethyl amines (2006) - Bioorganic &
Medicinal Chemistry, Volume 14, Issue 24, 8186-8196
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Tripathi, R.P.,
Verma, S.S., Pandey, Jyoti, Agarwal, K.C., Chaturvedi,
Vinita, Manju, Y.K., Srivastva, A.K., Gaikwad, A. and
Sinha, S. - Search of antitubercular activities in tetrahydroacridines:
Synthesis and biological evaluation (2006) - Bioorganic
& Medicinal Chemistry Letters, Volume 16,
Issue 19 , 5144-5147 |
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Tripathi, Rama
P, Katiyar Diksha, Dwivedi Namrata, Singh Biswajit
K & Pandey Jyoti - Recent developments in search of
antifilarial agents (2006) - Current Medicinal
Chemistry, 13, 3319-34. |
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Verma, Shyam Sundar, Dwivedi
Namrata, Singh Biswajit K & Tripathi Rama
P. - BU assisted expeditious synthesis of glycosyl
dienes via glycosylated beta-hydroxy esters. (2006)
- Carbohydrate Research, 341, 1930-37. |
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Bajpai, Preeti ; Verma,
Shailendra Kumar ; Katiyar, Diksha ; Tewari, Neetu ; Tripathi,
R P ; Bansal, Iti ; Saxena, J K ; Misra-Bhattacharya,
Shailja . - Search for new prototypes for the chemotherapy
of filariasis: a chemotherapeutic and biochemical approach,
(2005) - Parasitology Research, Volume
95, Issue 6, 383-390. |
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DBU/ TBAB/4A0
Catalysed cyclatic amidation reactions: A highly efficient
& convenient synthesis of C-Nucleosides. N. Tewari,
R.C.Mishra, V.K.Tiwari, R.P.Tripathi SYNLETT, 2002, No11,
1779-1782 |
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Glycosylated
-amino acids as new class of antitubercular agents R.
P. Tripathi,a* R. Tripathi,a V.K.Tiwari, Laxmi Bala,b
S. Sinha,b A. Srivastava,c R. Srivastava,c B.S. Srivastavac
Eur. J. Med. Chem, 2002 , 37, 773-781. |
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DBU Assisted
Cyclorelease Elimination: Combinatorial Synthesis and
-glutamyl cystein synthetase & glutathione-S- transeferase
Modulatory Activity of C- nucleoside anlogs R.C. Mishra,
Neetu Tewari, Kavita Arora, Rumana Ahmad, R.P.Tripathi
, V.K.Tiwari, R. D. Walter and A.K. Srivatava, , Combi
Chem & Highthroughtput Screening 2003, 6, 37-50 |
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Synthesis
and bioevaluation of glycosyl ureas as -glucosidase inhibitors
and antituberculosis agents: Neetu Tewaria, V.K. Tiwari,
R.C. Mishra, R.P. Tripathi, A.K.Srivastava, R. Ahmad,
R. Srivastava and B.S.Srivastava. Bioorg. Med. Chem.,
2003,11, 2911-2922 . |
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Amberlite
IR -120 Catalysed Efficient Synthesis of Glycosyl Enaminones
and their Con version to Dihydropyridones, Neetu Tewari,
Diksha Katiyar and Rama P. Tripathi Tetrahedron Lett.
2003 in press. |
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| SELECT PATENTS |
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Diglycosylated
diaminoalcohol as novel antitubercular agents Ramapati
Tripathi, Vinod Kumar Tiwari, Neetu tewari, Ranjana
Srivastava, Sudhir Srivastava, Vinita Chaturvedi,
Kishor Kumar Srivastava, Brahm Shankar Srivastava. |
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A process
for the preparation of diglycosylated diaminoalcohol
as antitubercular agents Ramapati Tripathi, Vinod
Kumar Tiwari, Neetu tewari, Ranjana Srivastava,
Sudhir Srivastava, Vinita Chaturvedi, Kishor Kumar
Srivastava, Brahm Shankar Srivastava |
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Novel
Galactopyranosylated aminoalcohols useful in chemotherapy
of tubercular infections Ramapati Tripathi, Neetu
tewari, Ram Chandra Mishra, Ranjana Srivastava,
Sudhir Sinha, Anil Srivastava, Vinita Chaturvedi,
Kishor Kumar Srivastava, Brahm Shankar Srivastava,
INF/PAT/09/02. |
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A process
for the preparation of Galactopyranosylated aminoalcohols
useful in chemotherapy of tubercular infections
Ramapati Tripathi, Neetu tewari, Ram ChandraMishra,
Ranjana Srivastava, Sudhir Sinha, Anil Srivastava,
Vinita Chaturvedi, Kishor Kumar Srivastava, Brahm
Shankar Srivastava, INF/PAT/09/02 |
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Novel
1,3,5-thiazidine -2-thiones useful in chemotherapy
of tubercular infections Ramapati Tripathi, Diksha
Katiyar, Ranjana Srivastava, Anil Srivastava, Vinita
Chaturvedi, Kishor Kumar Srivastava, Brahm Shankar
Srivastava, NF/556/02 |
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A process
for the preparation of 1,3,5-thiazidine -2-thiones
useful in chemotherapy of tubercular infections
Ramapati Tripathi, Diksha Katiyar, Ranjana Srivastava,
Anil Srivastava, Vinita Chaturvedi, Kishor Kumar
Srivastava, Brahm Shankar Srivastava, NF/555/02 |
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