DR. RAVI S AMPAPATHI
 
  Scientist E I, NMR Group
Sophisticated Analytical Instrument Facility
Central Drug Research Institute (CSIR)
Lucknow-226001, U.P., India
 
E-Mail ravi_sa@cdri.res.in
 
EDUCATION & AWARDS
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 Ph.D. (Chemistry) Osmania University (2004) (Work carried out at IICT, Hyderabad)
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 M.Sc.,(Chemistry) Sri Krishna Devaraya University (1998).
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 Long term visitor CERM, Florence, Italy (2002)
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 Pharmacoinformatics Fellow Gulf Coast region, Texas, U.S.A. (2005)
 
POST-DOCTORAL RESEARCH
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 Postdocotoral Fellow, University of Houston, TX, U.S.A., 2004-2007
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 Visiting Fellow, National Cancer Institute, Frederick, MD, U.S.A.2007-2009
 
RESEARCH GROUP
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 Pancham Singh Kandiyal (JRF)
•
 Shrikant Sharma (JRF)
 
RESEARCH AREAS
Structure-Function studies of proteins by NMR, CD and other Biophysical techniques. Insitu protein folding followed by NMR. We also work on designing and conformational studies of bio-active Peptides and Peptidomimetics.
 
CURRENT RESEARCH PROGRAMS
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 Structure-function studies of bacterial toxin proteins
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 NMR Based screening of ligands with the receptor targets
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 Conformational Studies of Peptides & Peptidomimetics
 
SELECTED PUBLICATIONS
 
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 “Stereoselective construction of quaternary chiral centers using Ti(III)-mediated opening of 2,3-epoxy alcohols: studies directed toward the synthesis of penifulvins”. T. K. Chakraborty, A.K. Chattopadhyay, R. Samanta, R. S. Ampapathi. Tetrahedron letters, 51, 4425-4428 (2010).
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 “Order-Disorder-Order Transitions Mediate the Activation of Cholera Toxin” Ravi S. Ampapathi, Creath, A.L., Lou, D.I., Craft, J.W., Blanke, S.R. & Legge, G.B, J. Mol. Biol, 377, 748-60 (2008)
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 “A Left handed 9-helix in gama-peptides: Synthesis and conformational studies of Oligomers with Dipeptide Repeats of C-linked Carbo-gama4-aminoacids and gama-Amino butyric Acid”.G. V. M. Sharma, P. Jayaprakash, K. Narasimulu, Ravi S. Ampapathi, P. RadhaKrishna, and A. C. Kunwar, Angew. Chem. Int. Ed., 45, 2944-2947 (2006).
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 “De Novo Design and Synthesis of Helix-Turn-Helix Structure from Short and Robust Mixed Helices Derived from C-Linked Carbo-beta-Amino Acids”, G.V.M. Sharma, V. Subhash, K. Narasimulu, Ravi S. Ampapathi and A. C. Kunwar, Angew. Chem. Int. Ed., 45, 8207-10 (2006).
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 “Novel Helical Twists in “Mixed beta-peptides” Derived From Alternating C-Linked Carbo-beta3-aminoacids (Caa) and beta-hGly”, G. V. M. Sharma, K. Ravinder Reddy, P. Radhakrishna, Ravi S. Ampapathi, P. Jayaprakash, B. Jagannadh and A. C. Kunwar, Angew. Chem. Int. Ed., 116, 4051-4055 (2004).
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 “Robust Mixed 10/12 Helices Promoted by ‘Alternating Chirality” in a New Family of C-linked Carbo-beta-Peptides”, G.V.M.Sharma, K. RavinderReddy, P. RadhaKrishna, Ravi S. Ampapathi, K. Narasimulu, S. KiranKumar, P. Jayaprakash, B. Jagannadh and A. C. Kunwar, J. Am. Chem. Soc., 125, 13670-13671 (2003).
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 “Furanoid sugar amino acid based peptidomimetics: well-defined solution conformations to gel-like structures”, T. K. Chakraborty, S. Jayaprakash, S. Madhavendra, Ravi S. Ampapathi and A. C. Kunwar, Tetrahedron, 58, 2853-2859 (2002).
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 “Asymmetric synthesis of (+) talo-quercitol via free radical cyclo isomerisation of enantiomerically pure alkyne-tethered aldehyde derived from carbohydrate”, J. S. Yadav, A. Maiti, Ravi S. Ampapathi and A. C. Kunwar, J. Org. Chem., 66, 8370-8378 (2001).
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 “Synthesis and conformational Studies of Peptido-Mimetics Containing a Carbocyclic 1,3-Diacid”, T.K. Chakraborty, A. Ghosh, R. Nagaraj, Ravi S. Ampapathi and A. C. Kunwar, Tetrahedron, 57, 9196-9175 (2001).
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 “Synthesis and Structural Studies of Oligomers of 6-Amino-2,5-Anhydro-6-Deoxy-D-Mannonic Acid”, T.K. Chakraborty, S. Jayaprakash, P. Srinivasu, M. G. Chary, P. V. Diwan, R. Nagaraj, Ravi S. Ampapathi, A. C. Kunwar, Tetrahedron Lett., 41, 8167-8171 (2000).