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SAFETY
& CLINICAL DEVELOPMENT
PHARMACEUTICS |
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The
Pharmaceutics group is mainly involved in
analytical method development, quality assurance
and pre-formulation studies on candidate
drugs, and development of drug delivery
systems. Industry-academia collaborations
are also undertaken for innovative product
development research in the areas of biodegradable
and biocompatible nanoparticles and microparticles,
lipid and surfactant vesicles, layer-by-layer
(LBL) nano-fabrication, pulmonary delivery,
transdermal delivery and conventional dosage
forms. Current interests include delivery
systems for infectious diseases, diabetes
and osteoporosis. The transmission electron
micrograph below shows hollow LBL nanocapsules
prepared in the lab.
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Centchroman
is one of CDRI’s Flagship drugs, currently
under production at Hindustan Latex Ltd.
The Pharmaceutics Division is currently
engaged in generating data required for
product registration in other countries,
and in development of novel formulations
using this agent. We have recently licensed
Consap Cream, a vaginal application for
contraception to HLL Lifecare. Alternative
delivery systems for the active ingredients
of Consap (Sapindus saponin) are under development.
A surprisingly efficacious herbal-based
formulation against cerebral ischemia, code-named
“Herbal Medicament” has also
been licensed to Themis Medicare. Collaboration
for developing a novel dry powder inhalation
formulation for use in tuberculosis is underway
with M/s. Lupin Laboratories, funded by
the NMITLI program of CSIR. Links have also
been established with the CSIR’s OSDD
Initiative to investigate genome-wide transcription
responses to drug delivery systems prepared
in the lab. Capacity-building in preparation
of drug delivery systems using supercritical
fluid methods is underway through a CSIR-Royal
Society collaboration with the Institute
of Pharmaceutical Innovation, University
of Bradford, UK. Work on nanometer-sized
drug delivery systems has been pursued fruitfully
in collaboration with the Freie Universität,
Berlin. |
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The
bar chart below demonstrates our ability
to prepare monodisperse, non-aggregating,
reproducible batches of polymeric biodegradable
nanoparticles of mean diameter ~75 nm. Any
of several possible known and candidate
drugs, peptides, antigens and nucleic acids
can be incorporated in these. The accompanying
fluorescent micrographs shows that such
small particles instilled into the vagina
of mice can overcome the barrier imposed
by the cervix, and light up the walls of
the uterine endometrium. Administered orally,
they can be taken up into lacteals of the
intestinal villi. Nanoparticles targeting
proteins expressed at higher density on
the surface of erythrocytes infected with
the malaria parasite are under development. |
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| Team
members |
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Dr.
A K Dwivedi
Dr. Amit Misra
Dr. P R Mishra
Dr. M K Chourasia
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website
copyright © Central Drug Research Institute.
All rights reserved.
No part of this should be Downloaded or used
in any way other than the non-commercial purposes
without prior permission of the Director,
CDRI. |
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