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SAFETY
& CLINICAL DEVELOPMENT
TOXICOLOGY |
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Toxicology
group is involved in profiling of candidate
drugs according to schedule Y guidelines.
Systemic toxicology, reproductive toxicology,
genetic toxicity, immunotoxicity and local
toxicity and carcinogenicity are being done
for NCEs.
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GENOTOXICITY
TESTS |
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I.
Ames assay: S typhimurium reverse mutation
assay |
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II.
Chromosomal assay |
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........................................In
Vitro |
........................In
Vivo |
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III.
SCE assay |
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........................................In
Vitro |
........................In
Vivo |
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IV
Micronucleus assay |
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........................................In
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TERATOLOGICAL
TESTS |
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Further,
we are also involved in studying DNA polymorphisms
and Disease association and development
of alternative test systems in the areas
of nephrotoxicity, hepatotoxicity, carcinogenesis,
teratology, immunotoxicity, neurtoxicity
and genotoxicity that may reduce, refine
and may replace the use of animals in toxicity
testing, and provide vital information on
safety/mechanism of toxicity/metabolism
of drugs. C. elegans is also now being developed
as a model for toxicity evaluation. |
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Figure
showing NEF induces lipodystrophy in C.
elegans |
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Assessment
of Neurotoxicity of Rotenone by Comet test
in neuronal cell line |
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Control |
Treated |
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Assessment
of hepatotoxicity by Fluorescent Microscopy
in hepatic cell line |
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| Team
members |
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Dr S. Sharma
Dr SK Rath
Dr RK Tripathi
Dr RK Singh
Dr A Nazir
Dr Smrati Bhadauria
Dr Sarika Singh
Dr Poonam Singh |
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website
copyright © Central Drug Research Institute.
All rights reserved.
No part of this should be Downloaded or used
in any way other than the non-commercial purposes
without prior permission of the Director,
CDRI. |
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