Dr. SANJAY BATRA
 
Medicinal Chemistry Division
Central Drug Research Institute
PO Box 173,
Lucknow 226 001.
 
Phone No. 91-0522-2612411-18 Ext 4368
Fax No. 91-0522-2623405, 2623938
E- mail s_batra@cdri.res.in
Educational Qualifications M.Sc, Ph.D
Date of Birth

6th September 1965
 
POST DOCTORAL EXPERIENCE
 
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 From University of Mississippi, University MS 38677 USA during Nov. 2000-Nov. 2001
 
RESEARCH INTEREST
 
•
 Design and Synthesis of antimalarial agents
• Search for new scaffolds and pharmacophores
• Synthesis of Hybrid compounds
•
 Development of chemistry associated with the Baylis-Hillman reaction
• Search for new fast reacting electrophiles
• Synthesis of novel synthetic intermediates
• Synthesis of heterocycles
-Aza-systems
-Drug scaffolds
-Natural products and natural product mimics
•
 Catalytic hydrogenation of 2-isoxazolines and isoxazoles
 
RESEARCH STUDENTS
PhD Students
Dr. Amrendra K. Roy Senior Research Scientist Reddy’s Pharma, Hyderabad
Dr. Richa Pathak DAAD-Fellow Prof. A. Marx (Konstanz Univ)
Dr. Vijay Singh PDF Prof. A. G. Hartig (Konstanz Univ)
Mr. Sudharshan Madapa Research Scientist Aurigene, Bangalore
Post Docs
Dr. Rashmi Saxena 2003-2005  
Dr. Zehra Tusi 2006-2008 (under DST-WOS-A scheme)
Present students
Mr. Somnath Nag SRF(UGC)  
Mr. Virender Singh
 SRF (CSIR)  
Ms. Amita Mishra SRF(CSIR)  
Mr. Samiran Hutait SRF(CSIR)  
Mr. Maloy Nayak SRF(CSIR)  
Mr. Subhendu Bhowmik JRF(CSIR)  
Mr. Subhasish Biswas
 (JRF, CSIR)  
 
Instruction for Students desirous of working with me
Candidates with good academic track record can apply. All candidates applying for graduate position in my group should post their CV with their recent photograph, a paragraph about motivation to do research and two letters of references. Preference shall be given to candidates a) with good academic record; b) have completed a project work (as part of their masters program) or have some experience in pharma/chemical industry and c) have good communication skills.
SELECTED PUBLICATIONS
 
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 Expeditious synthesis of fused-benzodiazocines. A. Mishra and Sanjay Batra Eur. J. Org.
Chem. 2010, in press.
•
 Application of primary allyl amines from Morita-Baylis-Hillman adducts: Cyanogen-azide-mediated synthesis of substituted 5-aminotetrazoles and their attempted transformation to
tetrazolo[1,5-a]pyrimidinones. S. Nag, S. Bhowmik, H. M. Gauniyal and Sanjay Batra
Eur. J. Org. Chem. 2010, in press.
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 Utility of allyl azide for the synthesis of annulated triazoles and tetrazoles. A. Mishra, S. Hutait, S. Bhowmik, N. Rastogi, R. Roy and Sanjay Batra Synthesis 2010, in press.
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 Advancing the Baylis-Hillman chemistry of 1-formyl-b-carbolines for the
synthesis of indolizinoindole derivatives. V. Singh, S. Hutait , and Sanjay Batra Eur. J. Org. Chem. 2010, web released 19th May.
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 Isonitriles from the Baylis-Hillman adducts of acrylates: Viable precursor to tetrazolo-fused diazepinones via post-Ugi cyclization. M. Nayak and Sanjay Batra Tetrahedron Lett. 2010, 51, 510-516.
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 Versatility of substituted 1-formyl-9H-?-carbolines for the synthesis of new fused ?-carbolines via intramolecular 1,3-Dipolar Cycloaddition. V. Singh, S. Hutait, S. Biswas and Sanjay Batra Eur. J. Org. Chem. 2010, 531-539.
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 Baylis-Hillman reaction of 1-formyl-?-carboline: one-step synthesis of the canthin-6-one framework via an unprecedented cascade cyclization. V.Singh, S. Hutait and Sanjay Batra Eur. J. Org. Chem. 2009, 6211-6216.
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 First Copper-catalyzed intramolecular amidation in substituted 4-iodopyrazoles leading to the synthesis of pyrazolo[4,3-b]pyridin-5-ones. S. Nag, M. Nayak and Sanjay Batra, Adv. Synth. Catal. 2009, 351, 2715-2723.
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 Search for new pharmacophores for antimalarial activity (Part III): Synthesis and bioevaluation of new 6-thioureido-4-anilinoquinazolines. A. Mishra, K. Srivastava, R. Tripathi, S. K. Puri, and Sanjay Batra Eur. J. Med. Chem. 2009, 44, 4404-4412
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 Synthesis of 2-amino-3,4-dihydroquinazolines and imidazo[2,1-b]quinazoline-2-ones. A. Mishra and Sanjay Batra Synthesis 2009, 3077-3088
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 Stereoselective synthesis of homoallyl nitroalkane derivatives via base-promoted regioselective decarboxylation in Baylis-Hillman derivatives. M. Nayak and Sanjay Batra Eur. J. Org. Chem. 2009, 3505-3507.
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 Reductive-cyclization-mediated syntheses of fused polycyclic quinolines from the Baylis-Hillman adducts of acrylonitrile: Scope and limitations. V. Singh, S. Hutait and Sanjay Batra Eur. J. Org. Chem. 2009, 3454-3466.
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 Unusual retention of isoxazole ring under the influence of 3-(substituted nitrophenyl)-2-isoxazoline during catalytic-hydrogenation of isoxazoline substituted isoxazole system. V. Singh, S. Hutait, G. P. Yadav, P. R. Maulik and Sanjay Batra. J. Heterocyclic Chem. 2009, 46, 762-769.
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 Malaria and Leishmaniasis. Current Status of chemotherapy, New Leads and Targets for Drug Development. R. Pathak and Sanjay Batra AIA- Med. Chem. 2009, 226-267.
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 S. Madapa, Z. Tusi, A. Mishra, K. Srivastava, R. Tripathi, S. K. Puri and Sanjay Batra- Search for new pharmacophores for antimalarial activity (Part II): Synthesis and antimalarial activity of new 6-ureido-4-anilinoquinazolines. . Bioorg. Med. Chem. 2009, 17, 222-234.
•
 S. Madapa, Z. Tusi, A. Mishra K. Srivastava, R. Tripathi, S. K. Puri and Sanjay Batra- Search for new pharmacophores for antimalarial activity (Part I): Synthesis and antimalarial activity of new 2-methyl-6-ureido-4-quinolinamides.. Bioorg. Med. Chem. 2009, 17, 203-221.
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 M. Nayak, S. Kanojiya and Sanjay Batra. First synthesis of allyl isonitriles from Baylis-Hillman adducts and their synthetic application for obtaining substituted imidazo[1,2-a]pyridine and dibenzoazulene systems. Synthesis 2009, 431-437.
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 S. Nag, A. Mishra and Sanjay Batra- A facile route to the synthesis of pyrimido[2,1-b]quinazoline core from the primary allyl amines afforded from Baylis-Hillman adducts. Tetrahedron 2008, 64, 10162-10171.
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 Madapa S, Tusi Z and Batra Sanjay - Advances in the synthesis of quinoline and quinoline-annulated ring systems (2008) - Current Organic Chemistry 12, 1116-1183
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 Nag S, Madapa S and Batra Sanjay - Application of primary allyl amines afforded by the Baylis-Hillman adducts for heterocyclic synthesis: Generation of 5-benzyl-4(3H)-pyrimidinones and 2-benzylidene-2,3-dihydro-pyrrolizin-1-ones (2008) - Synthesis (2008), 101-109
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 Nag S, Mishra A and Batra Sanjay - A Facile construction of 6-arylmethyl-imidazo[1,2-a]pyrimidin-7-ylamines from the allyl amines derived from the Baylis-Hillman adducts (2008) - Eur. J. Org. Chem ( 2008), 4334-4343.
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 Singh V and Batra Sanjay - Advances in the Baylis-Hillman Reaction-Assisted Synthesis of Cyclic Frameworks (2008) - Tetrahedron 64, 4511-4574 (Awarded most cited publication for the year 2006-2009 from TETRAHEDRON)
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 Singh V, Madapa S and Batra Sanjay - P2O5-promoted efficient and diastereoselective synthesis of substituted 5-methylene-dihydropyran-2,6-diones and 3-methylene-3,4-dihydropyran-2-ones (2008) - Synth. Commn. 38, 2113-2124
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 Singh Virender, Singh Vijay and Batra Sanjay - Straightforward strategy for stereoselective synthesis of spiro-fuzed (C-5)isoxazolino or (C-3)pyrazolino-(C-3)-quinolin-2-ones from Baylis-Hillman adducts via 1,3-dipolar cycloaddition and reductive cyclization (2008) - Eur. J. Org. Chem ( 2008), 5446-5460
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 Singh Virender, Yadav Gaya P, Maulik Prakas R and Batra Sanjay - Synthesis of substituted 3-methylene-2-pyridones from Baylis–Hillman derivatives and its application for the generation of 2-pyridone substituted spiroisoxazolines (2008) - Tetrahedron 64, 2979-2991
•
 Madapa Sudharshan, Sridhar Divya, Yadav Gaya P, Maulik Prakas R and Batra Sanjay. - A general approach to the synthesis of substituted isoxazolo[4,3-c]quinolines via chalcones. (2007) - European Journal of Organic Chemistry (2007), 4343-4351
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 Nag S, Singh V and Batra Sanjay. - Studies on the Baylis-Hillman reaction of pyrazolecarbaldehydes under the influence of DABCO: Positional effect on the reactivity of the formyl group. (2007) - ARKIVOC XIV, 185-203
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 Pathak R and Batra Sanjay - Expeditious synthesis of 5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidin-2-ones and 3,4,6,7,8,9-hexahydro-pyrimido[1,2-a] pyrimidin-2-ones (2007) - Tetrahedron 63, 9448-9955
•
 Pathak R, Madapa S and Batra Sanjay - Trifluoroacetic acid: A more effective and efficient reagent for the synthesis of 3-arylmethylene-3,4-dihydro-1H-quinolin-2-ones and 3-arylmethyl-2-amino quinolines from Baylis-Hillman derivatives via Claisen rearrangement. (2007) - Tetrahedron 63, 451-460
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 Singh Vijay and Batra Sanjay - Synthesis of substituted 1H- and 3H-1-benzazepines and rearrangement of alkyl 1H-1-benzazepine-2-carboxylates into isoquinolines . (2007) - European Journal of Organic Chemistry (2007), 2970-2976
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 Singh Vijay, Pathak Richa and Batra Sanjay - Significant yield improvement in the stereoselective synthesis of allyl cyanides from Baylis-Hillman derivatives in aqueous medium under the influence of the phase-transfer catalyst. (2007) - Catalysis Communications 8, 2048-2052
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 V. Singh, S. Kanojiya and Sanjay Batra (2006). Studies on the reduction of nitro group in 3-aryl- 2-methylene-4-nitro-alkanoates afforded by the Baylis-Hillman adducts: Synthesis of 4-aryl-3-methylene-2-pyrrolidinones and 3-(1-alkoxycarbonyl-vinyl)-1H-indole-2-carboxylates. Tetrahedron. 62, 10100-10110
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 V. Singh and Sanjay Batra (2006). Tributyltin hydride-mediated straightforward synthesis of a new isoxazolo-benzazulene ring system. Tetrahedron Lett. 47, 7043-7045
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 S. Madapa, V. Singh and Sanjay Batra (2006). An alternate approach to quinoline architecture via Baylis-Hillman chemistry: SnCl2-mediated tandem reaction toward synthesis of 4-(substituted vinyl)-quinolines. Tetrahedron 62, 8740-8747.
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 V. Singh, G. P. Yadav, P. R. Maulik and S. Batra (2006). Studies toward the construction of substituted piperidine-2-ones and pyridine-2-ones from Baylis-Hillman adducts: Discovery of facile synthesis of 5-methyl-4-oxo-6-aryl-3-aza-bicyclo[3.1.0]hexane-1-carboxylates. Tetrahedron 62, 8731-8739.
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 S. Nag, R. Pathak, M. Kumar, P. K. Shukla and Sanjay Batra (2006). Synthesis and antibacterial evaluation of ureides of Baylis-Hillman derivatives. Bioorg. Med. Chem. Lett., 16, 3824-3828.
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 V. Singh, S. Madapa, G. P. Yadav, P. R. Maulik and Sanjay Batra (2006). Interesting results of catalytic hydrogenation of 3-(2-nitrophenyl)-isoxazoles and 3-(nitro-substituted-phenyl)-2-isoxazolines. Synthesis, 1995-2004.
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 A. K. Roy, R. Pathak, G. P. Yadav, P. R. Maulik and Sanjay Batra (2006). Neighboring group effect: DBU-mediated ring transformation of substituted isoxazoles to pyrroles. Synthesis 1021-1027
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 R. Pathak, V. Singh, S. N. Nag, S. Kanojiya and Sanjay Batra (2006). Alternate, Easy and Practical Synthesis of Allylamines from Acetyl Derivatives of Baylis–Hillman Adducts Using Methanolic Ammonia. Synthesis, 813-816.
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 V. Singh and Sanjay Batra (2006). A convenient synthesis of substituted α-methylene-d-valerolactones in aqueous medium using Baylis-Hillman chemistry. Synthesis, 63-70.
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 G. Gupta, R. K. Jain, J. P. Maikhuri, P. K. Shukla, M. Kumar, A. K. Roy, A. Patra, V. Singh, Sanjay Batra (2005). Discovery of substituted isoxazolecarbaldehydes as spermicides, acrosin inhibitors and mild antifungal agents. Human Reproduction 20(8), 2301-2308.
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 R. Pathak, A. K. Roy and Sanjay Batra (2005). A facile route to the synthesis of novel 2-amino-1,4,5,6-tetrahydropyrimidines from Baylis-Hillman products of acrylonitrile. Synlett, 848-850
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 V. Singh, R. Saxena, and Sanjay Batra (2005). Simple and efficient synthesis of substituted 2-pyrrolidinones, 2-pyrrolones and pyrrolidines from enaminones of Baylis-Hillman derivatives of 3-isoxazolecarbaldehydes. J. Org Chem. 70(1), 353-356