Biodata of Dr K. V. Sashidhara :::: Central Drug Research Institute

Dr. K. V. Sashidhara

...

Scientist E- I
Medicinal and Process Chemistry Division
Central Drug Research Institute
Chattar Manzil Palace
Lucknow 226001, UP, India

Educational Qualifications	M.Sc., Ph.D. (Faizabad)
Date of Birth	10th January, 1973
E- mail	sashidhar123@gmail.com,kv_sashidhara@cdri.res.in
Phone No.	+91-0522-2612411-18, Ext. 4437
Fax No.	+91-0522-2643405, 2623938
Research Experience (Area)	Medicinal chemistry including natural Products. (10 years)

AWARDS/ FELLOWSHIP RECEIVED

•	Recipient of CDRI Incentive Award for excellent research work resulting in the research publication in high impact factor journal. (2010)
•	Recipient of EMPOWER (Encouraging and Motivating Pursuit of World Class Exploratory Research) research grant by Council of Scientific and Industrial Research (CSIR) New Delhi. (2010)
•	Is on the panel of course coordinator for JNU pre PhD and on the guest faculty of NIPER Raebareli.
•	BOYSCAST fellowship of DST, Govt. of India. (University of California, Santa Cruz, USA from March 2008 to March 2009, with Prof. Phillip Crews)
•	FAST TRACK project for young scientist approved by DST.

CURRENT AREAS OF INTEREST

•	Design and Synthesis of ‘nature like molecules’ as potential pharmacological agents with special emphasis to Coumarin - as a biologically active scaffold.
•	Isolation and Characterization of bioactive natural products by activity directed fractionation and its development as potential leads.
•	New drug leads discovered/ invented and patented by my group include- • 4655/K09- Antidyslipidemic agent • S-009-131- Anticancer agent

Recognized Ph.D guide in Chemistry in the following Universities

•	Jawaharlal Nehru University (JNU), New Delhi.
•	Acharya Nagarjuna University, Guntur, A.P.
•	Meerut University, Meerut
•	Lucknow University, Lucknow UP.

Supervisory details :Supervised two students for their PhD and Six students for their Post Graduation degrees.

Current research group
1. Jammikuntla N Rosaiah (SRF)- Thesis awarded (March 2010)
2. Abdhesh Kumar (SRF)- Thesis submitted (March 2011)
3. Manoj Kumar (SRF)
4. P. Gopala Reddy (JRF)
5. A. Srinivasa Rao (JRF)
6. M. Ram Kumar (JRF)
7. K. Bhaskara Rao (JRF)
8. Ranga Prasad Dodda (JRF)
9. S P Singh (TA)

Former post-graduate students
1. Shakti Deep Pachauri (2005)
2. Pratima Katiyar (2005)
3. Ruchi Khandelwal (2006)
4. Suman Rani (2006)
5. Anchal Misra (2007)
6. Bikash Kumar (2010)

Publications and Patents for the last five years (2007 - 2011)

•	*Koneni V. Sashidhara,** Suriya P. Singh, Anuj Srivastava, Anju Puri. Identification of the antioxidant principles of Polyalthia longifolia var. pendula using TEAC assays. *Natural Product Research*. 2011, 25(9): 918-926
•	*Koneni V. Sashidhara, Abdhesh Kumar, Manavi Chatterjee, K. Bhaskara Rao, Seema Singh, Anil Kumar Verma, Gautam Palit. Discovery and synthesis of novel 3-phenylcoumarin derivatives as antidepressant agents Bioorganic & Medicinal Chemistry Letters**. 2011, 21(7): 1937-1941
•	*Koneni V. Sashidhara,** Suriya P. Singh, Anuj Srivastava, Anju Puri, Yashpal S. Chhonker, Rabi S. Bhatta, Priyanka Shah, Mohammad Imran Siddiqi. Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent *European Journal of Medicinal Chemistry. 2011 Volume 46, Issue 10, October 2011, Pages 5206-5211*
•	*Koneni V. Sashidhara, Manoj Kumar, Ram K. Modukuri, Ravi Sonkar, Gitika Bhatia, A.K. Khanna, Shivika Rai, Rakesh Shukla. Synthesis and anti-inflammatory activity of novel biscoumarin–chalcone hybrids Bioorganic & Medicinal Chemistry Letters**, 2011, 21(15): 4480-4484.
•	*Koneni V. Sashidhara, Abdhesh Kumar, K. Bhaskara Rao. Synthesis of 3,6-epoxy[1,5]dioxocines from 2-hydroxyaromatic benzaldehydes Tetrahedron Letters*, 2011 Volume 52, Issue 43, Pages 5659-5663*
•	R. S. Bhatta, Devendra Kumar, Y. S. Chhonker, Deepak Kumar, Suriya P. Singh, Koneni V. Sashidhara, G. K. Jain. Simultaneous estimation of 16α-hydroxycleroda-3,13(14) Z-dien-15,16-olide from Polyalthia longifolia and its metabolite in hamster plasma: application to pharmacokinetic study Biomedical Chromatography*, 2011 Jul 20; DOI 10.1002/bmc.1672 In press, Corrected Proof, Available online
•	*Koneni V. Sashidhara, Abdhesh Kumar, Manoj Kumar, S. Singh, Manish Jain, Madhu Dikshit. Synthesis of novel 3-carboxamide-benzocoumarin derivatives as orally active antithrombotic agents. Bioorganic & Medicinal Chemistry Letters**, 2011, 21(23): 7034-7040
•	*Koneni V. Sashidhara, Manoj Kumar, Ram K. Modukuri, Anuj Srivastava, Anju Puri Discovery and synthesis of novel substituted benzocoumarins as orally active lipid modulating agents. Bioorganic & Medicinal Chemistry Letters**, 2011, 21(22): 6709-6713.
•	*Koneni V. Sashidhara, Suriya P. Singh, Jayanta Sarkar, Sudhir Sinha. Cytotoxic clerodane diterpenoids from the leaves of Polyalthia longifolia. Natural Product Research**. 2010, 24, 1687-1694
•	Pragya Misra, *Koneni V Sashidhara,** Suriya Pratap Singh, Awanish Kumar, Reema Gupta Shailendra S Chaudhaery, Souvik Sen Gupta, H K Majumder, Anil K Saxena,and Anuradha Dube* 16α-hydroxycleroda-3,13 (14) z-dien-15, 16-olide from polyalthia longifolia: A safe and orally active antileishmanial agent. *British Journal of Pharmacology*. 2010, 159(5): 1143-1150
•	Tyler A. Johnson, Micaela V. C. Morgan, Natalie A. Aratow, Samarkand A. Estee, Koneni V. Sashidhara, Steven T. Loveridge, Nathaniel L. Segraves and Phillip Crews* Assessing pressurized liquid extraction for the high-throughput extraction of marine-sponge-derived natural products. *Journal of Natural Products*. 2010, 73(3): 359-364
•	*Koneni V. Sashidhara, Jammikuntla N. Rosaiah, Abdhesh Kumar. Unusual reaction of 6-formyl-2-ox-2H-benzo[h]chromene-3-carboxylic acid ethyl ester with aliphatic amines. Synthetic Communications**. 2010, 1, 21-28
•	*Koneni V. Sashidhara, Jammikuntla N. Rosaiah, Abdhesh Kumar, Gitika Bhatia, A.K. Khanna. Synthesis of novel benzocoumarin derivatives as lipid lowering agents. Bioorganic & Medicinal Chemistry Letters**. 2010 May 15, 20(10): 3065-3069
•	J. Brian Morgan, Fakhri Mahdi, Yang Liu, Veena Coothankandaswamy, Mika B. Jekabsons, Tyler A. Johnson, Koneni V. Sashidhara, Phillip Crews, Dale G. Nagle, Yu-Dong Zhou The marine sponge metabolite mycothiazole: a novel prototype mitochondrial complex I inhibitor. *Bioorganic & Medicinal Chemistry*. 2010, 18(16): 5988-5994
•	*Koneni V. Sashidhara, Abdhesh Kumar, Manoj Kumar, Ravi Sonkar, Gitika Bhatia, A.K. Khanna Novel coumarin derivatives as potential antidyslipidemic agents. Bioorganic & Medicinal Chemistry Letters**. 2010, 20(14): 4248-4251
•	*Koneni V. Sashidhara, Suriya P. Singh, Ruchir Kant, Prakas R. Maulik, Jayanta Sarkar, Sanjeev Kanojiya, K. Ravi Kumar Cytotoxic cycloartane triterpene and rare isomeric bisclerodane diterpenes from the leaves of Polyalthia longifolia var. pendula. Bioorganic & Medicinal Chemistry Letters**. 2010; 20(19): 5767-5771
•	*Koneni V. Sashidhara, Abdhesh Kumar, Manoj Kumar, Anuj Srivastava, Anju Puri. Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives. Bioorganic & Medicinal Chemistry Letters**. 2010, 20(22): 6504-6507
•	*Koneni V. Sashidhara, Jammikuntla N. Rosaiah, Manoj Kumar, Rishi Kumar Gara, Lakshma Vadithe Nayak, Kamini Srivastava, Hemant Kumar Bid, Rituraj Konwar. Neo-tanshinlactone inspired synthesis, in vitro evaluation of novel substituted benzocoumarin derivatives as potent anti-breast cancer agents. Bioorganic & Medicinal Chemistry Letters**. 2010, 20(22): 7127-7131
•	*Koneni V. Sashidhara, Abdhesh Kumar, Manoj Kumar, Jayanta Sarkar, Sudhir Sinha. Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters**. 2010, 20(24): 7205-7211
•	*Koneni V. Sashidhara,** Jammikuntla N. Rosaiah, Abdhesh Kumar. New protocol for masking and unmasking vicinal hydroxyl and formyl groups in 6-hydroxyarene-1,3-dicarboxaldehydes. Synthetic Communications. 2009, 39, 1809-1816
•	*Koneni V. Sashidhara, Jammikuntla N. Rosaiah, Abdhesh Kumar. Iodine catalyzed mild and efficient method for the synthesis of chalcones. Synthetic Communications**. 2009, 39, 2288-2296
•	Tyler A. Johnson, Taro Amagata, Koneni V. Sashidhara, Allen G. Oliver, Karen Tenney, Teatulohi Matainaho, Kenny Kean-Hooi Ang, James H. McKerrow and Phillip Crews* The aignopsanes, a new class of sesquiterpenes from selected chemotypes of the sponge Cacospongia mycofijiensis. *Organic Letters*. 2009, 11(9):1975-1978
•	*Koneni V. Sashidhara, Jammikuntla N. Rosaiah, Ethika Tyagi, Rakesh Shukla, Ram Raghubir, Siron M. Rajendran Rare dipeptide and urea derivatives from roots of Moringa oleifera as potential anti-inflammatory and antinociceptive agents. European Journal of Medicinal Chemistry**. 2009; 44(1): 432-436
•	*Koneni V. Sashidhara, Abdhesh Kumar, Gitika Bhatia, M.M. Khan, A.K. Khanna, J.K. Saxena. Antidyslipidemic and antioxidative activities of 8-hydroxyquinoline derived novel keto-enamine Schiffs bases. European Journal of Medicinal Chemistry**. 2009, 44(4):1813-1818
•	*Koneni V. Sashidhara, Suriya P. Singh, P.K. Shukla. Antimicrobial evaluation of clerodane diterpenes from Polyalthia longifolia var. pendula. Natural Product Communications**. 2009, 4(3): 327-330
•	Koneni V. Sashidhara, Kimberly N. White and Phillip Crews. A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products. Journal of Natural Products*. 2009, 72(3): 588-603
•	*Koneni V. Sashidhara, Jammikuntla N. Rosaiah, Gitika Bhatia, J.K. Saxena. Novel keto-enamine Schiffs bases from 7-hydroxy-4-methyl-2-oxo-2H-benzo[h] chromene-8,10-dicarbaldehyde as potential antidyslipidemic and antioxidant agents. European Journal of Medicinal Chemistry**. 2008, 43(11): 2592-6
•	*Koneni V. Sashidhara, Jammikuntla N. Rosaiah. Vicarious nucleophilic substitution in enamine derivatives of 1-hydroxynaphthalene-2,4- dicarbaldehyde. Tetrahedron Letters**. 2007, 48(18): 3285-3287
•	*Koneni V. Sashidhara,** Jammikuntla N. Rosaiah, Tadigoppula Narender* Highly efficient and regioselective synthesis of keto-enamine Schiff bases of 7-Hydroxy-4-methyl-2-oxo-2H-benzo[h]chromene-8,10-dicarbaldehyde and 1-Hydroxynaphthalene-2,4-dicarbaldehyde. *Tetrahedron Letters*. 2007, 48(10): 1699-1702
•	*Koneni V. Sashidhara, Jammikuntla N. Rosaiah. Various dereplication strategies using LC-MS for rapid natural product lead identification and drug discovery. Natural Product Communications**. 2007, 2(2): 193-202
•	*Koneni V. Sashidhara, Jammikuntla N. Rosaiah, Abdhesh Kumar, Hemant K Bid, Rituraj Konwar, Naibedya Chattopadhyay. Cell growth inhibitory action of an unusual labdane diterpene, 13-epi-sclareol in breast and uterine cancers in vitro. Phytotherapy Research**. 2007, 21(11):1105-1108