|
| |
| Dr.
SHAILJA BHATTACHARYA (NEE MISRA) |
|
 |
... |
Scientist F
Division of Parasitology,
Central Drug Research Institute,
Post Box 173, Lucknow (U.P.) - 226001, India |
| |
| |
| Fax No. |
+ 91 - 0522 - 2223938
/ 2223405 |
| E-Mail |
shailjacdri[at]yahoo dot com |
| Educational Qualifications |
M.Sc. (Zoology), Ph.D. |
| Date of Birth |
19.03.1956
|
|
| |
| POST
DOCTORAL RESEARCH |
| |
|
•
|
Institute
for Tropical Hygiene, Heidelberg, Germany, 1987-1989
Identification and purification of an immunodominant antigen
of filarial parasite A. viteae using immunological and molecular
biology techniques. |
|
•
|
Institute for Parasitology, Giessen, Germany, Sept.-December,
1997
Molecular cloning of sheath proteins of filarial parasite L.
carinii.
|
| |
| RESEARCH
EXPERIENCE |
| |
|
•
|
27 years
research experience on development of in vitro and in
vivo models, molecular and immunobiological studies including
characterization and purification of protective and diagnostic
filarial antigens, development of antifilarial agents
from natural and synthetic source |
|
| |
| CURRENT
AREAS OF INTEREST |
| |
|
•
|
· Immunobiology, chemotherapy and molecular
biology of filarial parasites
- Development macrofilaricide from natural products
- Development of models and studies on host-parasite
interactions in B. malayi mouse model
- Identification and molecular characterization of immunodominant
antigens of filariids
- Evaluation of immunomodulatory activity in plant products
and use of immunomodulators alone or as an adjunct to
chemotherapy
- Role of endosymbiont bacteria Wolbachia in filarial
host-parasite interactions.
- Effector cell function in imparting resistance to
filarial infection.
|
|
|
| Ph
D GUIDANCE TO STUDENTS |
| |
Four students have been awarded PhD degree:
Ms. Manisha Dikshit
Ms. Monisha Mukherjee
Ms. Usha Singh
Ms. Ruma Gupta
PhD thesis work of following students is underway:
Ms. Preeti Bajpai
Mr. Shailendra Kumar Verma
Mr. Satish Vedi
Mr. Anil Dangi
|
| |
| SELECTED
PUBLICATIONS |
| |
• |
Dwivedi Varun, Khan Arif,
Vasco Azevedo, Fatima Nishat, Soni Vishal Kumar, Dangi
Anil, Misra-Bhattacharya Shailja and
Owais Mohammad - Immunomodulator effect of picroliv and
its potential in treatment against resistant Plasmodium
yoelii (MDR) infection in mice (2008) - Pharmaceutical
research 25, 2312-9 |
• |
Jain Vikas, Sahu Rajnish,
Misra- Bhattacharya Shailja, Suresh P
Vyas and Kohli Dharmveer - Enhancement of T helper type
I immune responses against hepatitis B Surface antigen
by LPS derivatives adjuvanted liposomes delivery system
(2008) - J. Drug Targeting 16, 706-715
|
• |
Mathew Nisha, Misra-Bhattacharya
Shailja, Perumal Vanamail and Muthuswamy Kalyanasundaram
- Antifilarial lead molecule isolated from Trachyspermum
ammi (2008) - Molecules 13, 2156-2168
|
• |
Shakya Shilpy, Bajpai
Preeti, Sharma Sharad and Mishra-Bhattacharya
Shailja - Prior killing of intracellular bacteria
Wolbachia reduces inflammatory reaction and improves antifilarial
efficacy of diethylcarbamazine in rodent model of Brugia
malayi (2008) - Parasitol Research 102,
963-972 |
• |
Vedi Satish, Dangi Anil,
Hajela Krishnan and Misra-Bhattacharya Shailja
- Vaccination with 73 kDa recombinant heavy chain myosin
generates high level of protection against Brugia malayi
challenge in jird and mastomys models (2008) -
Vaccine 26, 5997-6005 |
• |
Verma SK, Bansal I, Vedi
S, Saxena JK, Katoch VM and Bhattacharya SM
- Molecular cloning, purification and characterisation
of myosin of human lymphatic filarial parasite Brugia
malayi. (2008) - Parasitol Research 102,
481-9 |
• |
Bajpai P, Srivastava K,
Shakya S, Saxena PN and Misra-Bhattacharya S
- Improvement in the efficacy of existing combination
of antifilarials by inclusion of tetracycline in rodent
model of brugian filariasis. (2007) - Current
Science 92, 655-658 |
• |
Misra Namita, Sharma Mithilesh,
Dangi Anil, Kanwal Raj, Srivastava Sudhir K and Misra-Bhattacharya
Shailja. - Chemical constituents and antifilarial
activity of Lantana camara against human lymphatic filariid
Brugia malayi and rodent filariid Acanthocheilonema viteae
maintained in rodent hosts. (2007) - Parasitology
Research 100, 439-448 |
• |
Mohanty BP, Lahiri R ,
Misra-Bhattacharya S and Kar SK. - Brugia
malayi adult low molecular weight IgG4-reactive antigens
induce differential cytokine response in lymphocytes of
endemic normal and asymptomatic microfilariae carriers
in vitro. (2007) - J Clin Immunol 27,
397-408 |
• |
Sharma Sharad Kumar, Gupta
Chittarmal, Dwivedi Varun, Misra-Bhattacharya
Shaija and Owais Mohammad - Prophylactic potential
of liposomized integral membrane protein of Plasmodium
yoelii nigeriensis against blood stage infection in BALB/c
mice . (2007) - Vaccine 25, 2103-2111
|
• |
Srivastava, Kumkum, Vedi
Satish, Srivastava Sudhir and Misra-Bhattacharya
Shailja - Wuchereria bancrofti: Effect of single
and multiple larval inoculations on infection dynamics
and development of clinical manifestations in non-human
primate Presbytis entellus. (2007) - Experimental
Parasitology 115, 305-309 |
• |
Bhatnagar, S, Bhattacharya
S & Chatterjee R K. - Acanthocheilonema vitae
in Mastomys coucha: Chemotherapeutic and chemoprophylactic
role of vitamin A in experimental filarial infection.
Z (2006) - Naturforsch :61, 285-88. |
• |
Sharma, Sharad Kumar,
Farah, Deba, Misra-Bhattacharya, Shailja,
Bajpai, Preeti, Agarwal, Anshu and Mohammad ,Owais - Escheriosome
entrapped soluble blood stage antigens impart protective
immunity against a multi-drug resistant isolate of Plasmodium
yoelii nigeriensis in BALB/c mice (2006) - Vaccine,
Volume 24, Issue 7, 948-956. |
• |
Srivastava, Kumkum, Vedi
Satish, Srivastava Sudhir & Misra-Bhattacharya
Shailja. - Wuchereria bancrofti: Effect of single
and multiple larval inoculations on infection dynamics
and development of clinical manifestations in non-human
primate Presbytis entellus. (2006) - Experimental
Parasitology , 115, 305-09. |
• |
Tripathi, Shweta, Singh
Nasib, Shakya Shilpi, Dangi Anil, Misra-Bhattacharya
Shailja, Dube Anuradha & Kumar Nikhil - Landrace/gender-based
differences in phenol and thiocynate contents and biological
activity in Piper betel L. (2006) - Current Science,
91, 746-49 |
• |
Bajpai, Preeti ; Verma,
Shailendra Kumar ; Katiyar, Diksha ; Tewari, Neetu ; Tripathi,
R P ; Bansal, Iti ; Saxena, J K ; Misra-Bhattacharya,
Shailja . - Search for new prototypes for the
chemotherapy of filariasis: a chemotherapeutic and biochemical
approach, (2005) - Parasitology Research,
Volume 95, Issue 6, 383-390. |
• |
Bajpai, Preeti, Vedi,
Satish, Owais, Mohammad, Sharma, Sharad K, Saxena, Prabh
N & Misra-Bhattacharya, Shailja -
Use of liposomized tetracycline in elimination of Wolbachia
endobacterium of human lymphatic filariid Brugia malayi
in a rodent model (2005) - Journal Of Drug Targeting,
13, 375-381 |
• |
Dube, A., Murthy, P.K.,
Puri, S.K. & Misra-Bhattacharya, S.
- Presbytis entellus: A primate model for parasitic disease
research. (2004) - Trends in Parasitology,
20, 358-360. |
| • |
Macrophages
in the development of protective immunity against experimental
Brugia malayi infection. Ruma Gupta, P. Bajpai,
L. M. Tripathi, V. M. L. Srivastava, S. K. Jain and Shailja
Misra-Bhattacharya, Parasitology (2004)
129 (3) 1-13. |
| • |
4-Methyl-7-(tetradecanoyl)-2H-1-benzopyran-2-one:
A novel DNA topoisomerase II inhibitor with adulticidal
and embryo static activity against sub periodic Brugia
malayi. Shailja Misra-Bhattacharya, Diksha
Katiyar, Preeti Bajpai; R. P. Tripathi & J. K. Saxena.
Parasitology Res., 92 (3) 177-182, Feb. 2004. |
| • |
Immunomodulator
tuftsin augments antifilarial activity of Diethylcarbamazine
against experimental Brugian filariasis. Owais, M., Misra-Bhattacharya,
S., Haq, W., Gupta, C. M. J. Drug Targ. (2003)
11 (4) 247-251 |
| • |
Brugia
malayi: Establishment in inbred and outbred strains
of mice. Ruma Gupta, K. Tyagi, S. K. Jain & Shailja
Misra-Bhattacharya. Experimental Parasitology,
103, (issue 1-2) 57-60 (2003). |
| • |
Immunomodulatory
effect of Albizzia lebbeck. C. C. Barua, P. P.
Gupta, G. K. Patnaik, Shailja Bhattacharya, R.
K. Goel, D. K. Kulshrestha, M.P. Dubey & B.N. Dhawan.
Pharmaceutical Biology, 38, 1-5 (2000). |
| • |
Experimental
transmission of nocturnally periodic Wuchereria bancrofti
to Indian leaf monkey (Presbytis entellus). S. Misra,
K. Tyagi & R.K. Chatterjee. Experimental Parasitology.
86, 155-157 (1997). |
| |
| |
|
|
| |
|
| |
|