Dr. Mohammad Imran Siddiqi
  Scientist -E-I
Computational Biology & Bioinformatics Group
Molecular and Structural Biology Division
Central Drug Research Institute
Lucknow- 226001
U.P., India
 
Educational Qualifications M.Sc. (Biophysics) A.I.I.M.S., New Delhi
Ph.D. (Biophysics) A.I.I.M.S., New Delhi
Telephone +91 522 2612411 extn- 4468
Fax +91 522 2623405
E- Mail imsiddiqi@yahoo.com
Date of Birth 30.03.1971
 
POST-DOCTORAL RESEARCH
 
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 University of Wuerzburg, Germany (August, 2000- Januay,2003)
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 Biotechnology Research Institute, Montreal , NRC Canada (Feb, 2003- March,2004)
CURRENT RESEARCH AREAS
 
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 Informatics: Bio-informatics and Cheminformatics
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 Computational Structural biology: Biomolecular engineering & Modeling, Computer-Aided Molecular Design and Simulation.
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 Rational Drug design: Virtual screening, de novo design, pharmacophore perception, SAR and ADME, Molecular docking, Conformational Analysis, Binding free energy simulations and Protein Ligand interactions.
 
SELECTED PUBLICATIONS
 
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 Knowledge based identification of potent anti-tubercular compounds using structure based virtual screening and structure interaction fingerprints. Kumar, A., Chaturvedi,V., Bhatnagar, S., Sinha, S., and Siddiqi, M.I. J. Chem. Info. and model.,2009, 49(1) 35-42, http://pubs.acs.org/doi/abs/10.1021/ci8003607)
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 3D-QSAR studies of xanthone derivatives as human alpha glucosidase inhibitors. Saqib, U. and Siddiqi,M.I., Int. Journal of Integrative Biology, 2009,Vol 5(1); 13-19.
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 Search for new pharmacophores for antimalarial activity (Part-I): Synthesis and antimalarial activity of new 2-methyl-6-ureido-4-quinolinamides Madapa, S.,Tusi,Z., Sridhar,D., Kumar,A., Siddiqi,M.I., Srivastava,K., Rizvi, A., Tripathi, R., Puri,S.K., Keshava,G.B.S., Shukla, P.K., and Batra,S., 2009, Bioorg. Med. Chem. Jan1;17(1):203-221;doi:10.1016/j.bmc.2008.11.021
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 Molecular docking studies on DMDP derivatives as human DHFR inhibitors. Srivastava, V., Kumar, A., Mishra, B.N., and Siddiqi, M.I. Bioinformation, 2008, 3(4), 180-188.
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 Virtual screening against Mycobacterium tuberculosis Dihydrofolatreductase: Suggested workflow for compound prioritization using structure interaction fingerprints Kumar, A., and Siddiqi, M.I. J. Mol. Graph. and Model., 2008; 27(4) : 476-488 ; doi:10.1016/j.jmgm.2008.08.005
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 CoMFA based de novo design of pyrilidone carboxamides as inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis. Kumar, A. and Siddiqi, M.I., J. Mol. Model, October, 2008; 14 (10) : 923-35. doi:10.1007/s00894-008-0326-8.
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 Leishmania donovani Pteridine Reductase 1: Biochemical Properties and Structure-Modeling studies. Kumar, P., kumar, A., Verma,S.S., Dwivedi,N., Singh, N., Siddiqi, M.I., Tripathi, R.P., Dubey, A., and Singh, N. Experimental Parasitol., September 2008, Volume 120, (1): 73-79, doi:10.1016/j.exppara.2008.05.005
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 An unconventional form of actin in protozoan haemoflagellate, Leishmania. Kapoor,P., Sahasrabuddhe,A.A., Kumar,A., Mitra,K., Siddiqi, M.I. , and Gupta, C.M. J. Biol. Chem., 2008, August 15; 283 (33): 22760-73. published online June 5 as doi:10.1074/jbc.M800213200
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 Molecular and biochemical characterization of plasmodium falciparum transketolase. Joshi, S., Singh, A.K., Kumar, A., Mishra, P.C., Siddiqi, M.I. and Saxena, J.K. Mol Biochem Parasitol. 2008 Jul;160 (1):32-41.
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 Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans, Dixit, M., Saeed, U., Kumar, A., Siddiqi, M.I., Tamrakar, A.K., Srivastava, A.K. and Goel, A. Medicinal Chemistry, 2008, Jan , 4(1): 18-24.
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 Probing ligand binding interactions of human alpha glucosidase by homology modeling and molecular docking. Saqib, U. and Siddiqi, M.I. Int. Journal of Integrative Biology, 2008, Vol 2, (2) : 116-121.
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 CoMFA and CoMSIA 3D - QSAR analysis of 2, 4-diamino-5-methyl-5-deazapteridine (DMDP) derivatives as anti-cancer agents. Srivastava, V., Kumar, A., Mishra, B.N., and Siddiqi, M.I. Bioinformation, 2008, Vol 2, Issue 9, 384-391.
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 Nuclear gyrB encodes a functional subunit of the Plasmodium falciparum gyrase that is involved in apicoplast DNA replication. Raghu Ram, EVS, Kumar, A., Biswas, S., Kumar, A., Chaubey, S., Siddiqi, M.I. and Habib, S., Mol Biochem. Parasit. 2007, July, 154: 30-39.
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 Ligand based Virtual Screening and Biological Evaluation of Inhibitors of Chorismate Mutase (Rv1885c) from Mycobacterium tuberculosis H37Rv. Agrawal, H., Kumar, A., Bal, N.C., Siddiqi M.I., and Ashish Arora, Bioorg. Med. Chem. Letts, 2007; Jun 1;17(11):3053-3058.
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 Amino acid based enantiomerically pure 3-substituted benzodiazepine-ones : a new class of anti-ischemic agents. Mishra, J.K., Garg, P., Doohare, P., Kumar, A., Siddiqi, M.I. Ray, M. and Panda, G. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1326-1331.
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 Solvated interaction energy (SIE) for scoring protein-ligand binding affinities. 1. Exploring the parameter space. Naim, M., Bhat, Sathesh, Rankin; K. N., Dennis, S., Chowdhury, S. F., Siddiqi, M. I., Drabik, P., Sulea T., Bayly, C., Jakalian ,A. and Purisima, E.O. J. Chem. Info. and Model., 2007, Jan 22, 47(1) : 122-133.
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 Molecular Docking Studies on 4-Thiazolidinones as HIV-1 RT Inhibitors. Ravindra K. Rawal, Ashutosh kumar, Siddiqi, M. I. and S.B. Katti. J Mol Model, 2007, Jan;13(1):155-61.
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 CoMFA and CoMSIA based 3D-QSAR Analysis of Diaryloxy methano phenanthrene Analogues as Anti-tuberculosis Agents. Shagufta, Ashutosh Kumar, Gautam Panda and Siddiqi, M.I., J Mol Model. 2007, Jan;13(1):99-109.
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 Molecular Docking and 3-D QSAR Studies of Human Mitotic Kinesin Eg5 Inhibitors. Kumar, A., Saeed, U. and Siddiqi, M.I. Med. Chem. Res., 2006, 15 (1/6); Page 243.
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 A peptide inhibitor of HIV-1 Protease using ?,?- dehydro residues: A stucture based approach. Siddiqui, M.I., Kataria, S., Ahuja, V. and Subba Rao G, Ind. J. Biochem & Biophy, 2001, Vol 38, Feb-April, 90-95.
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 Structure-based design of mutation resistant peptide inhibitor of HIV-1 reverse transcriptase, Subba Rao, G, Siddiqui, M.I., Ahuja, V., Bhatnagar, S and Tondon, H. (abstract) J Hum Virol. 2000, Vol 3, No. 5, 262.
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 Molecular modelling of the HIV-1 Tat protein - TAR RNA complex and the design of an inhibitor of the Tat/TAR RNA interaction. Subba Rao, G., Siddiqui, M.I. and Arora, S., J. Biomol. Struc. Dynam. 2000 Proceedings of the Eleventh Conversation, Part 1, Conversation 11, issue 1, May 2000, 65-74.
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 A peptide inhibitor of HIV-1 reverse transcriptase using ?,?- dehydro residues: A structure based approach. Subba Rao, G., Kataria, S. and Siddiqui, M.I., J.Biomol. Struc.Dynam. 1998, 16: 347-354.
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 The design of an inhibitor using ?,? -dehydro residues. Subba Rao, G., Siddiqui, M.I., and Arora,S., J. Biomol. struc. Dynam. 1996, 14: 21-24.