Dr. Mohammad Imran Siddiqi
  Scientist -C
Computational Biology & Bioinformatics Group
Molecular and Structural Biology Division
Central Drug Research Institute
Lucknow- 226001
U.P., India
 
Educational Qualifications M.Sc. (Biophysics) A.I.I.M.S., New Delhi
Ph.D. (Biophysics) A.I.I.M.S., New Delhi
Telephone +91 522 2612411 extn- 4468
Fax +91 522 2623405
E- Mail imsiddiqi@yahoo.com
 
POST-DOCTORAL RESEARCH
 
University of Wuerzburg, Germany (August, 2000- Januay,2003)
Biotechnology Research Institute, Montreal , NRC Canada (Feb, 2003- March,2004)
CURRENT RESEARCH AREAS
 
Informatics: Bio-informatics and Cheminformatics
Computational Structural biology: Biomolecular engineering & Modeling, Computer-Aided Molecular Design and Simulation.
Rational Drug design: Virtual screening, de novo design, pharmacophore perception, SAR and ADME, Molecular docking, Conformational Analysis, Binding free energy simulations and Protein Ligand interactions.
 
SELECTED PUBLICATIONS
 
Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans, Dixit, M., Saeed, U., Kumar, A., Siddiqi, M.I., Tamrakar, A.K., Srivastava, A.K. and Goel, A. Medicinal Chemistry, 2007 (in press)
Raghu Ram, EVS, Kumar, A., Biswas, S., Kumar, A., Chaubey, S., Siddiqi, M.I. and Habib, S. (2007) Nuclear gyrB encodes a functional subunit of the Plasmodium falciparum gyrase that is involved in apicoplast DNA replication. Mol Biochem. Parasit. 154, 30-39.
Agrawal, H., Kumar, A., Bal, N.C., Siddiqi M.I., and Arora, A. (2007) Ligand based Virtual Screening and Biological Evaluation of Inhibitors of Chorismate Mutase (Rv1885c) from Mycobacterium tuberculosis H37Rv., Bioorg. Med. Chem. Letts. 17(11), 3053-3058.
Mishra, J.K., Garg, P., Doohare, P., Kumar, A., Siddiqi, M.I. Ray, M. and Panda, G. (2007) Amino acid based enantiomerically pure 3-substituted benzodiazepine-ones : a new class of anti-ischemic agents. Bioorg Med Chem Lett. 17(5), 1326-1331.
Naim, M., Bhat, Sathesh, Rankin; K. N., Dennis, S., Chowdhury, S. F., Siddiqi, M. I., Drabik, P., Sulea T., Bayly, C., Jakalian, A. and Purisima, E.O. (2007) Solvated interaction energy (SIE) for scoring protein-ligand binding affinities. 1. Exploring the parameter space. J. Chem. Info. and model. 47(1), 122-133.
Rawal, R.K., kumar, A., Siddiqi, M. I. and Katti, S.B. (2007) Molecular Docking Studies on 4-Thiazolidinones as HIV-1 RT Inhibitors, J Mol Model, 13(1), 155-61.
Shagufta, Ashutosh Kumar, Gautam Panda and Siddiqi, M.I. (2007), CoMFA and CoMSIA based 3D-QSAR Analysis of Diaryloxy methano phenanthrene Analogues as Anti-tuberculosis Agents. J Mol Model. 13(1), 99-109.
Kumar, A., Saeed, U. and Siddiqi, M.I. (2006) Molecular Docking and 3-D QSAR Studies of Human Mitotic Kinesin Eg5 Inhibitors. Med. Chem. Res. 15 (1/6), 243.