|
| |
|
Dr. Mohammad Imran Siddiqi |
|
 |
|
Scientist -E-I
Computational Biology & Bioinformatics Group
Molecular and Structural Biology Division
Central Drug Research Institute
Lucknow- 226001
U.P., India
|
| |
| Educational Qualifications |
M.Sc. (Biophysics) A.I.I.M.S.,
New Delhi
Ph.D. (Biophysics) A.I.I.M.S., New Delhi |
| Telephone |
+91 522 2612411 extn- 4468 |
| Fax |
+91 522 2623405 |
| E- Mail |
imsiddiqi@yahoo.com |
| Date of Birth |
30.03.1971 |
|
| |
| POST-DOCTORAL
RESEARCH |
| |
| |
University
of Wuerzburg, Germany (August, 2000- Januay,2003) |
|
Biotechnology Research
Institute, Montreal , NRC Canada (Feb, 2003- March,2004) |
|
| CURRENT
RESEARCH AREAS |
| |
| |
Informatics:
Bio-informatics and Cheminformatics |
|
Computational
Structural biology: Biomolecular engineering
& Modeling, Computer-Aided Molecular Design and Simulation. |
|
Rational Drug
design: Virtual screening, de novo design, pharmacophore
perception, SAR and ADME, Molecular docking, Conformational
Analysis, Binding free energy simulations and Protein
Ligand interactions. |
|
| |
| SELECTED
PUBLICATIONS |
| |
|
Knowledge based identification
of potent anti-tubercular compounds using structure based
virtual screening and structure interaction fingerprints.
Kumar, A., Chaturvedi,V., Bhatnagar, S., Sinha, S., and
Siddiqi, M.I. J. Chem. Info.
and model.,2009, 49(1) 35-42, http://pubs.acs.org/doi/abs/10.1021/ci8003607) |
|
3D-QSAR studies of xanthone
derivatives as human alpha glucosidase inhibitors. Saqib,
U. and Siddiqi,M.I., Int. Journal
of Integrative Biology, 2009,Vol 5(1); 13-19. |
|
Search for new pharmacophores
for antimalarial activity (Part-I): Synthesis and antimalarial
activity of new 2-methyl-6-ureido-4-quinolinamides Madapa,
S.,Tusi,Z., Sridhar,D., Kumar,A., Siddiqi,M.I.,
Srivastava,K., Rizvi, A., Tripathi, R., Puri,S.K., Keshava,G.B.S.,
Shukla, P.K., and Batra,S., 2009, Bioorg.
Med. Chem. Jan1;17(1):203-221;doi:10.1016/j.bmc.2008.11.021 |
|
Molecular docking studies
on DMDP derivatives as human DHFR inhibitors. Srivastava,
V., Kumar, A., Mishra, B.N., and Siddiqi, M.I.
Bioinformation, 2008, 3(4), 180-188. |
|
Virtual screening against
Mycobacterium tuberculosis Dihydrofolatreductase: Suggested
workflow for compound prioritization using structure interaction
fingerprints Kumar, A., and Siddiqi, M.I.
J. Mol. Graph. and Model., 2008;
27(4) : 476-488 ; doi:10.1016/j.jmgm.2008.08.005 |
|
CoMFA based de novo design
of pyrilidone carboxamides as inhibitors of enoyl acyl
carrier protein reductase from Mycobacterium tuberculosis.
Kumar, A. and Siddiqi, M.I., J.
Mol. Model, October, 2008; 14
(10) : 923-35. doi:10.1007/s00894-008-0326-8. |
|
Leishmania donovani Pteridine
Reductase 1: Biochemical Properties and Structure-Modeling
studies. Kumar, P., kumar, A., Verma,S.S., Dwivedi,N.,
Singh, N., Siddiqi, M.I., Tripathi, R.P.,
Dubey, A., and Singh, N. Experimental Parasitol.,
September 2008, Volume 120, (1): 73-79,
doi:10.1016/j.exppara.2008.05.005 |
|
An unconventional form
of actin in protozoan haemoflagellate, Leishmania. Kapoor,P.,
Sahasrabuddhe,A.A., Kumar,A., Mitra,K., Siddiqi,
M.I. , and Gupta, C.M. J. Biol. Chem.,
2008, August 15; 283 (33): 22760-73. published
online June 5 as doi:10.1074/jbc.M800213200 |
|
Molecular and biochemical
characterization of plasmodium falciparum transketolase.
Joshi, S., Singh, A.K., Kumar, A., Mishra, P.C., Siddiqi,
M.I. and Saxena, J.K. Mol Biochem Parasitol.
2008 Jul;160 (1):32-41. |
|
Synthesis, Molecular Docking
and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans
and Dibenzofurans, Dixit, M., Saeed, U., Kumar, A.,
Siddiqi, M.I., Tamrakar, A.K., Srivastava, A.K.
and Goel, A. Medicinal Chemistry, 2008,
Jan , 4(1): 18-24. |
|
Probing ligand binding
interactions of human alpha glucosidase by homology modeling
and molecular docking. Saqib, U. and Siddiqi,
M.I. Int. Journal of
Integrative Biology, 2008, Vol 2, (2) : 116-121.
|
|
CoMFA and CoMSIA 3D -
QSAR analysis of 2, 4-diamino-5-methyl-5-deazapteridine
(DMDP) derivatives as anti-cancer agents. Srivastava,
V., Kumar, A., Mishra, B.N., and Siddiqi, M.I.
Bioinformation, 2008, Vol 2, Issue 9, 384-391. |
|
Nuclear gyrB encodes a
functional subunit of the Plasmodium falciparum gyrase
that is involved in apicoplast DNA replication. Raghu
Ram, EVS, Kumar, A., Biswas, S., Kumar, A., Chaubey, S.,
Siddiqi, M.I. and Habib, S., Mol Biochem.
Parasit. 2007, July, 154: 30-39. |
|
Ligand based Virtual Screening
and Biological Evaluation of Inhibitors of Chorismate
Mutase (Rv1885c) from Mycobacterium tuberculosis H37Rv.
Agrawal, H., Kumar, A., Bal, N.C., Siddiqi M.I.,
and Ashish Arora, Bioorg. Med. Chem. Letts, 2007;
Jun 1;17(11):3053-3058. |
|
Amino acid based enantiomerically
pure 3-substituted benzodiazepine-ones : a new class of
anti-ischemic agents. Mishra, J.K., Garg, P., Doohare,
P., Kumar, A., Siddiqi, M.I. Ray, M.
and Panda, G. Bioorg Med Chem Lett. 2007 Mar
1;17(5):1326-1331. |
|
Solvated interaction energy
(SIE) for scoring protein-ligand binding affinities. 1.
Exploring the parameter space. Naim, M., Bhat, Sathesh,
Rankin; K. N., Dennis, S., Chowdhury, S. F., Siddiqi,
M. I., Drabik, P., Sulea T., Bayly, C., Jakalian
,A. and Purisima, E.O. J. Chem. Info. and Model.,
2007, Jan 22, 47(1) : 122-133. |
|
Molecular Docking Studies
on 4-Thiazolidinones as HIV-1 RT Inhibitors. Ravindra
K. Rawal, Ashutosh kumar, Siddiqi, M. I. and
S.B. Katti. J Mol Model, 2007, Jan;13(1):155-61.
|
|
CoMFA and CoMSIA based
3D-QSAR Analysis of Diaryloxy methano phenanthrene Analogues
as Anti-tuberculosis Agents. Shagufta, Ashutosh Kumar,
Gautam Panda and Siddiqi, M.I., J Mol Model. 2007,
Jan;13(1):99-109. |
|
Molecular Docking and
3-D QSAR Studies of Human Mitotic Kinesin Eg5 Inhibitors.
Kumar, A., Saeed, U. and Siddiqi, M.I. Med. Chem.
Res., 2006, 15 (1/6); Page 243. |
|
A peptide inhibitor of
HIV-1 Protease using ?,?- dehydro residues: A stucture
based approach. Siddiqui, M.I., Kataria,
S., Ahuja, V. and Subba Rao G, Ind. J. Biochem
& Biophy, 2001, Vol 38, Feb-April, 90-95. |
|
Structure-based design
of mutation resistant peptide inhibitor of HIV-1 reverse
transcriptase, Subba Rao, G, Siddiqui, M.I.,
Ahuja, V., Bhatnagar, S and Tondon, H. (abstract) J
Hum Virol. 2000, Vol 3, No. 5, 262. |
|
Molecular modelling of
the HIV-1 Tat protein - TAR RNA complex and the design
of an inhibitor of the Tat/TAR RNA interaction. Subba
Rao, G., Siddiqui, M.I. and Arora, S.,
J. Biomol. Struc. Dynam. 2000
Proceedings of the Eleventh Conversation, Part 1, Conversation
11, issue 1, May 2000, 65-74. |
|
A peptide inhibitor of
HIV-1 reverse transcriptase using ?,?- dehydro residues:
A structure based approach. Subba Rao, G., Kataria, S.
and Siddiqui, M.I., J.Biomol. Struc.Dynam. 1998,
16: 347-354. |
|
The design of an inhibitor
using ?,? -dehydro residues. Subba Rao, G., Siddiqui,
M.I., and Arora,S., J. Biomol. struc.
Dynam. 1996, 14: 21-24. |
| |
| |
|
|
| |
|
| |
|