|
| |
Dr S.K. Puri |
|
| |
 |
|
Scientist G
Scientist-in-Charge
Parasitology Division
Central Drug Research Institute
Lucknow-226 001 |
|
| |
| |
|
| Educational Qualifications |
M.Sc (Hons.), Ph.D |
| Date of Birth |
November 23rd, 1954 |
| E-Mail |
sk_puri@cdri.res.in |
| Fax |
91-522-2623405 |
|
| |
| POST DOCTORAL RESEARH |
| |
|
•
|
CDRI, Lucknow,
1979 to 1982 |
|
| |
| RESEARCH
EXPERIENCE |
| |
|
|
| |
| AREAS OF
RESEARH |
| |
|
•
|
Malaria Chemotherapy,
Immunoprophylaxis, Drug Resistance |
|
| |
| CURRENT AREAS OF INTEREST |
| |
|
•
|
Antimalarial
drug Development, Drug resistance, Experimental Malaria
models |
|
|
| RECENT PUBLICATIONS |
| |
| |
Gupta Leena, Srivastava
Kumkum, Puri SK, Singh Shubhra and Chauhan
Prem MS - Synthesis of 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted
phenyl)-2,3,4,9-tetrahydro-1H-ß-carbolines as a
new class of antimalarial agents (2008)
- Bioorganic and Medicinal Chemistry Letters
18, 6530-6533 |
| |
Kumar A, Srivastava K.
Rajakumar S, Puri SK and Chauhan PMS
- Sythesis and bioevaluation of hybrid 4-aminoquinoline
triazine as a new class of antimalarial agents (2008)
- Bioorganic and Medicinal Chemistry Letters
18, 6530-3 |
| |
Kumar Ashok, Srivastava
Kumkum, Puri SK, and Chauhan Prem MS
- Synthesis and bioevaluation of hybrid 4-aminoquinoline
triazines as a new class of antimalarial agents (2008)
- Bioorganic and Medicinal Chemistry Letters
18, 6530-6533 |
| |
Kumar S, Guha M, Choubey
V, Maity P, Srivastava K, Puri SK and
Bandyopadhyay U - Bilirubin inhibits Plasmodium falciparum
growth through the generation of reactive oxygen species
(2008) - Free Radical Biology & Medicine
44, 602-13 |
| |
Kumar Satish, Misra Namita,
Raj K, Srivastava Kumkum and Puri SK
- Novel class of hybrid natural products derived from
lupeol as antimalarial agents (2008) - Nat. Prod.
Res.22, 305-19 |
| |
Parai KM, Panda G, Srivastava
K and SK Puri - Design, synthesis and
antimalarial activity of benzene and isoquinoline sulfonamide
derivatives (2008) - Bioorganic and Medicinal
Chemistry Letters 18, 776-781 |
| |
Singh Ajit Shankar, Verma
Ved Prakash, Hassam Mohammad, Krishna, Naikade Niraj,
Puri Sunil K and Singh Chandan - Amino
and Hydroxy- Functionalized 11- Azaartemisinins and Their
Derivatives (2008) - Organic Letters
10, 5461–5464 |
| |
Singh C, Chaudhary, S
and Puri SK - Orally active esters of
dihydroartemisinin: Synthesis and antimalarial activity
against multidrug-resistant Plasmodium yoelii in mice
(2008) - Bioorganic and Medicinal Chemistry Letters
18, 1436-1441 |
| |
Singh Chandan, Verma Ved
Prakash, Naikade Niraj, Singh Ajit Shankar, Hassam Mohammad
and Puri Sunil K - Novel Bis-and Tris-1,
2, 4-Trioxanes: Synthesis and Antimalarial Activity Against
Multidrug-Resistant Plasmodium yoelii in Swiss Mice (2008)
- J. Med. Chemistry 51, 7581–7592 |
| |
Solomon VR, Haq W, Smilkstein
M, Srivastava K, Rajakumar S, Puri SK
and Katti SB - Synthesis and antimalarial activity of
novel side chain modified antimalarial agents derived
from 4-aminoquinoline (2008) - Med. Chem.
4, 446-56 |
| |
Choubey Vinay, Maity Pallab,
Guha Mithu, Kumar Sanjay, Srivastava Kumkum, Puri
Sunil Kumar and Bandyopadhyay Uday - Inhibition
of Plasmodium falciparum choline kinase by hexadecyltrimethylammonium
bromide: a possible antimalarial mechanism. (2007)
- Antimicrobial Agents and Chemotherapy 51, 696-706
|
| |
Guha Mithu, Choubey Vinay,
Maity Pallab, Kumar Sanjay, Srivastava Kumkum, Puri
Sunil K and Bandyopadhyay Uday. - Overexpression,
purification and localization of apoptosis related protein
from Plasmodium falciparum. (2007) - Protein Expression
and Purification 52, 363-372 |
| |
Kaushal DC, Kaushal NA,
Narula A, Kumar N, Puri SK, Dutta S and
Lanar DE. - Biochemical and immunological characterization
of E. coli expressed 42 kDa fragment of Plasmodium vivax
and P cynomolgi bastianelli merozoite surface protein.
(2007) - Indian J. Biochem. Biophys 44,
429- 436 |
| |
Mehrotra N, Lal J, Puri
SK, Madhusudanan KP and Gupta RC. - In vitro
and In vivo pharmacokinetic studies of bulaquine (analogue
of primaquine), a novel antirelapse antimalarial, in rat,
rabbit and monkey-highlighting species similarities and
differences. (2007) - Biopharm Drug Dispos
28, 209 -227 |
| |
Narender T, Reddy KP,
Shweta, Srivastava K, Mishra DK and Puri SK.
- Total synthesis of Munchiwarin, a triprenylated chalcone
from Crotalaria medicagenia. (2007) - Org Lett
9, 5369-5372 |
| |
Narender T, Tiwari P,
Shweta S, Reddy K Papi, Khaliq T, Prathipati P, Puri A,
Srivastava AK, Chander R, Agarwal SC and Raj K - Antihyperglycemic
and antidyslipidemic agent from Aegle marmelos. (2007)
- Bioorganic & Medicinal Chemistry Letters
17, 1808-1811 |
| |
Singh C, Chaudhary S,
R Kanchan and Puri SK - Conversion of
antimalarial drug artemisinin to a new series of tricyclic
1,2,4-trioxanes1. (2007) - Organic Letters
9, 4327-4329 |
| |
Singh Chandan, Rani Kanchan,
Sharma Upasana and Puri Sunil K - New
adamantane-based spiro 1,2,4-trioxanes orally effective
against rodent and simian malaria. (2007) - Journal
of Medicinal Chemistry 50, 521-527 |
| |
Singh Chandan, Sharma
Upasana, Saxena Gunjan and Puri Sunil K - Orally active
antimalarials: Synthesis and bioevaluation of a new series
of steroid-based 1,2,4-trioxanes against multi-drug resistant
malaria in mice. (2007) - Bioorganic & Medicinal
Chemistry Letters 17, 4097-4101 |
| |
Solomon V Raja, Haq W,
Srivastava Kumkum, Puri Sunil K and Katti SB - Synthesis
and antimalarial activity of side chain modified 4-aminoquinoline
derivatives (2007) - Journal of Medicinal Chemistry
50, 394-398 |
| |
Srivastava K, Singh S,
Singh P and Puri SK - In vitro cultivation of Plasmodium
falciparum: Studies with modified medium supplemented
with ALBUMAX II and various animal sera. (2007)
- Experimental Parasitology 116, 171-174 |
| |
Dutta, S, Kaushal DC,
Ware LA, Puri SK, Kaushal NA, Narula
A, Upadhyay DS & Lanar DE. - Merozoite surface protein-1
of Plasmodium vivax induces a protective response against
Plasmodium cynomolgi challenge in rhesus monkeys. (2006)
- Infection & Immunity, 73, 5936-44. |
| |
Singh, Chandan, Chaudhary
S & Puri SK. - New orally active
derivatives of artemisinine with high efficacy against
multi-drug resistant malaria in mice. (2006) -
J Medicinal Chemistry, 49, 7227-33. |
| |
Singh, Chandan; Malik,
Heetika; Puri, Sunil K - Orally active
1,2,4-trioxanes: synthesis and antimalarial assessment
of a new series of 9-functionalized 3-(1-arylvinyl)-1,2,5-trioxaspiro[5.5]undecanes
against multi-drug-resistant plasmodium yoelii nigeriensis
in mice (2006) - Journal Of Medicinal Chemistry,
49, 2794-2803 |
| • |
Puri, S.
K. and Dutta, G.P.(2003) Blood schizontocidal activity
of WR 238605 (Tafenoquine) against Plasmodium cynomolgi
and Plasmodium fragile infections in rhesus monkeys.
Acta Tropica 86: 35-43 |
| • |
Puri, S.K.
and Singh, N. (2000) Azithromycin: Antimalarial profile
against blood and sporozoite induced infections in mice
and monkeys Expl. Parasit. 94: 8-14 |
| • |
Singh N.
and Puri, S. K. (2000) Modulation of halofantrine
resistance after coadministration of halofantrine with
diverse pharmacological agents in a rodent malaria model.
Life Sciences, 67: 1345-1354 |
| • |
Singh, N.
and Puri, S. K. (1998) Causal prophylactic activity
of antihistaminic agents against Plasmodium yoelli infection
in Swiss mice. Acta Tropica 69: 255-260 |
| • |
Singh, S.;
Puri, S. K.; Singh, S. K.; Srivastava, R.; Gupta,
R. C. and Pandey, V. C. (1997). Characterization of simian
malarial parasite (Plasmodium knowlesi) induced putrescine
transport in rhesus monkey erythrocytes. Jr. Biol.
Chem. 272: 13506-13511. |
| |
| |
|
|
| |
|
| |
|