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Dr Shio Kumar Singh |
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Scientist E-II
Pharmacokinetics & Metabolism Division
Central Drug Research Institute
Chattar Manzil, Post Box No. 173
Lucknow - 226001 (India) |
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| EDUCATIONAL
QUALIFICATIONS |
| M.Sc.( Patna),
Ph. D.( IIT, Kanpur) |
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| SHOLASTIC ACHIEVEMENTS
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Postdoctoral
Fellowship by DST at IIT, Kanpur, 1987 |
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Research Scholarship at
IIT, Kanpur from 1981-1987 |
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| RESEARCH
ACTIVITIES |
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Development
of Bioanalytical Procedure for Active Molecules ( Synthetic
and Herbal ) and their Metabolites in Biological Matrices |
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Highthroughput
Pharmacokinetic (HTPK) Screening of Candidate Molecules
using LC/MS/MS Techniques |
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Pre-clinical
and Clinical Pharmacokinetic Studies (ADME) of Candidate
Drugs |
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In-vitro
and in-vivo Metabolic Studies of Candidate Molecules
and Stuctural Elucidation of its Metabolites |
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| MEMBERSHIP
OF SCIENTIFIC SOCIETIES |
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Life
Member : The Indian Pharmaceutical Society |
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Life Member
: The Indian Chemical Society |
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| FOREIGN
ASSIGNMENTS |
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Deputation
for GLP workshop on Thailand-Tropical Diseases Research
Programme (T-2) for pre-clinical studies, sponsored by
WHO, Geneva, Switzerland held at Bangkok, Thailand from
6-8 Sept., 1999. |
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Award
for visiting scientists to Germany under CSIR-DAAD Exchange
of Scientist programme 2003 from 30th June 2003 to 29th
Sept. 2003. |
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| HUMAN RESOURCE
DEVELOPMENT |
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Training
provided to Under Graduates and Post Graduates: 18 |
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| TOTAL
PUBLICATIONS |
Research Articles
: 42
Abstracts: 29
Patents: 04
Book Chapters: 02 |
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| SELECTED PUBLICATIONS |
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In-situ absorption,
protein binding and pharmacokinetic studies of S002-853,
a novel antidiabetic and antidyslipidemic flavone derivative
in rats, N.Gautam, H.N.Kushwaha, R. Pratap and S.K.
Singh, Journal of pharmacy and Pharmacology,
62 1-6 (2010). |
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Liquid chromatographic-tandem
mass spectrometry assay for quantitation of a novel antidiabetic
S002-853 in rat plasma and its application to pharmacokinetic
study, N. Gautam, R.P. Singh, R. Pratap and S.K.
Singh, Biomedical Chromatography,
Published Online, Oct 29, 2009. |
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Characterization
of sucrose-glutamic acid Maillard products (SGMPs) degrading
bacteria and their metabolites, R. Chandra, R.N. Bharagava,
V. Rai and S.K. Singh, Bioresource
Technology, 100 6665-6668 (2009). |
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Liquid
chromatographic tandem mass spectrometric assay for quantification
of 97/78 and its metabolite 97/63, a promising trioxane
antimalarial in monkey plasma, R. P. Singh, S. Sabarinath,
N. Gautam, R.C. Gupta and S.K. Singh,
Journal of Chromatography B, 877 2074-2080
(2009). |
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A
sensitive and selective liquid chromatographic tandem
mass spectrometric assay for simultaneous quantification
of novel trioxane antimalarials in different biomatrices
using sample-pooling approach for high throughput pharmacokinetic
studies, Rajendra Pratap Singh, S. Sabarinath, S.K.
Singh and R.C. Gupta, Journal of Chromatography
B., 864 52-60 (2008). |
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A
sensitive and selective HPLC/ESI-MS/MS assay for the simultaneous
quantification of 16- dehydropregnenolone and its major
metabolites in rabbit plasma, S. Suryawanshi, S.K.
Singh and R.C. Gupta; J. Chromatogr.
Biomed. Appl., 830 54-63 (2006).
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A
high throughput approach for simultaneous estimation of
multiple synthetic trioxane derivatives using sample pooling
for pharmacokinetic studies, R.P. Singh, S.K.
Singh and R.C. Gupta; J. Pharma. Biomed.
Anal., 37 127-133 (2005). |
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Pharmacokinetic
interaction of chloroquine and methylene blue combination
against malaria, J. Rengelshausen,, M. Fröhlich,
Y. Tayrouz, J. Burhenne, S. K. Singh,
K. D. Riedel, O. Müller, W. E. Haefeli, G. Mikus,
I. W. Sack, Eur. J. Clin. Pharmacol.,
60 709-715 (2004). |
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HPLC-UV method
for assaying 99/357, a synthetic trioxane antimalarial
derivative in rat and rabbit serum, S.K.Singh,
R.P.Singh and R.C.Gupta, J. Pharma. Biomed. Anal.,
36 371-376 (2004). |
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Pharmacokinetics,
in-situ absorption and protein-binding studies of a new
neuroleptic agent, centbutindole in rats, M. Issar, S.K.
Singh, B. Mishra and R.C. Gupta, Eur.
J. Pharma. Sci., 19 105-113 (2003). |
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