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| Md.
Sohail Akhtar |
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Scientist
Molecular and Structural Biology Division
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| POST-DOCTORAL
EXPERIENCE |
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Department
of Biochemistry, University of Wisconsin, Madison, WI,
USA (July 2007-July 2009) |
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| RESEARCH
AREAS |
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in vivo protein
folding, Transcription, Gene regulation |
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| CURRENT
AREA OF RESEARCH |
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We would employ
the in vivo protein folding, chromatin remodeling and
transcription in our studies. The other focus would be
to identify the novel interacting partners of CTD of RNA
Pol II due to specific phosphorylations and its associated
functions. |
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| HONOURS
& AWARDS |
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CSIR
Young Scientist Award-2006 |
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National Academy
of Sciences, India, Young Scientist Award-2006 |
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| SELECTED
PUBLICATIONS |
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Akhtar Md S, Heidemann
M, Tietjen JR, Zhang DW, Chapman RD, Eick D, Ansari AZ
(2009) TFIIH kinase places bivalent marks on the carboxy-terminal
domain of RNA polymerase II. Mol Cell. 34, 387-393 |
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Akhtar. Md. S.
and Bhakuni V. (2007) Role of ionic interactions
and linker in the domain interaction and modulation of
functional activity of hyaluronate lyase. Biochem.
Biophys. Res. Commun. 353, 286-292 |
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Akhtar. Md. S.,
Krishnan, MY. and Bhakuni V. (2006) Insight
into the mechanism of action of hyaluronate lyase; role
of C-terminal domain and Ca2+ in the functional regulation
of enzyme. J. Biol. Chem., 281, 28336-28344 |
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Mishra P., Akhtar,
Md. S. and Bhakuni V. (2006)
Unusual structural features of the bacteriophage-associated
hyaluronate lyase (HylP2). J. Biol. Chem., 281,
7143-7150 |
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Akhtar.
Md. S. and Bhakuni. V. (2004)
Streptococcus pneumoniae hyaluronate lyase: an overview.
Current Science. 86, 285-295. |
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Akhtar.
Md. S. and Bhakuni. V. (2003) Streptococcus
pneumoniae hyaluronate lyase contains two non-cooperative
independent folding/unfolding structural domains: characterization
of functional domain and inhibitors of enzyme. J. Biol.
Chem., 278, 25509-25516 |
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Akhtar.
Md. S. and Bhakuni. V. (2003) Alkaline treatment
has contrasting effects on the structure of deglycosylated
and glycosylated forms of glucose oxidase. Arch. Biochem.
Biophys., 413, 221-228 |
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Akhtar.
Md. S., Ahmad, A. and Bhakuni. V. (2002) Divalent
cation induced changes in structural properties of the
dimeric enzyme glucose oxidase: Dual effect of dimer stabilization
and dissociation with loss of cooperative interactions
in enzyme monomer. Biochemistry, 41, 7142-7149
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Akhtar.
Md. S., Ahmad, A. and Bhakuni. V. (2002) Guanidinium
chloride- and urea-induced unfolding of the dimeric enzyme
glucose oxidase. Biochemistry, 41, 3819-3827. |
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Ahmad, A.
Akhtar. Md. S., and Bhakuni. V. (2002) Monovalent
cation-induced conformational change in glucose oxidase
leading to stabilization of the enzyme. Biochemistry,
40, 1945-1955. |
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Note-
Please do not apply directly for summer training/ project
work/ Ph.D etc. For Summer training/Project work, you
may direct you application to the concerned authority
in TIILP division. For Ph.D, please see the
advertisements at CDRI website.
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