Dr. SRIKANTA KUMAR RATH
 
 

Scientist E-II
Genotoxicity Laboratory
Toxicology Division
Central Drug Research Institute
Lucknow 226001
 
Educational Qualifications Msc. Ph.D (Banaras)
Date of Birth 02.06.1965
Fax +91-0522-2623405
E-Mail rathsk_2000@]yahoo.com, ; skrath@cdri.res.in , genotoxicity@gmail.com
Phone No. +91-0522-2612411-18 Extn. 4316
 
 POST-DOCTORAL RESEARCH
 
Post Doctoral Research: CCMB, Hyderabad, 1995-1998
 
RESEARCH GROUP MEMBERS-
Presently Working

Shrawan Kumar Mishra, Senior Research Fellow, ICMR
Bipin Chand Misra, Senior Research Fellow, CSIR
Prabhat Singh, Junior Research Fellow, DBT
Sarvendra Vikram Singh, Junior Research Fellow, CSIR
Ajit Kumar Verma, Junior Research Fellow, CSIR
Pratibha Mishra, Project Assistant, ICMR
Pallavi Srivastava, Project Assistant, CSIR
Juma Ke Ojo, TWAS-CSIR Fellow

Past Members

Dr. Ashok Singh, presently Hermel Fellow, a University of Minnesota, USA
Dr. Sanjeev Noel, presently Post Doctoral Fellow at Johns Hopkins School of Public Health, Baltimore, USA
Amit Kumar Mitra, Post Doctoral Fellow, University of Minnesota, USA

 
NOTABLE RECOGNITIONS
 
2007: Raman Research Fellow
2007-08: Visiting Scientist, Johns Hopkins Bloomberg School of Public
Health, Baltimore, MD, USA
2008 : Genomic Pioneer Award
 
CURRENT AREAS OF INTEREST
 
Genotoxicity evaluation of new drug entities.
Development/Establishment of new in vitro assay systems to evaluate genotoxic effects of new candidate drugs and models for different diseases.
Studying Single Nucleotide Polymorphisms in drug metabolizing enzymes, DNA repair genes and cancer related genes in Indian populations.
Global gene expression studies following exposure to different toxicants using microarrays and real time PCR
 
SELECTED PUBLICATIONS
 
Mitra,A.K.,Singh, N., Singh, A., Garg, V.K., Sharma, M., Rashmi Chaturvedi , R. and Rath,S.K. (2009) Stastically significant association of the single nucleotide polymorphism (SNP) rs 13181 (ERCC 2) with predisposition to Squamous Cell Carcinomas of the head and neck ( SCCHN) and Breast Cancer in the north Indian population J Exptl Clinical Cancer Research.28(1):104
Singh , S.K. and Rath, S.K. (2009) Effect of Gossypol Tetra-acetic Acid on the Reproductive Organs in Male Mice. Recent Advances in Medicinal Plants, Studium press LLC,Houston 25, 159-176
Singh,N. Nigam, M., Ranjan, V, Sharma,R.S., Balapure, A. and Rath, S.K. (2009): Caspase mediated enhanced apoptotic action of Cyclophosphamide and Resveratrol treated MCF-7 cells. Journal of pharmacological sciences , 109,(4), 473-485
Brahma M.K., Dohare, P, Varma, S., Rath, S.K., Garg, P., Biswal, P.K., Dhar Chowdhury, P. and Ray, M. (2008): The neuronal apoptotic death in global cerebral ischemia in gerbil: important role for sodium channel modulator. Journal of Neuroscience Research, 87 (6), 1400-1411
Singh A, Boldin-Adamsky S, Thimmulappa RK, Rath SK, Ashush H, Coulter J, Blackford A, Goodman SN, Bunz F, Watson WH, Gabrielson E, Feinstein E, Biswal S. (2008) RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Research : 68 (19):7975-7984
Noel,S. Sharma, S. and Rath, S.K. (2008).Simultaneous application of t-test and fold change criteria to identify acetaminophen and carbon tetrachloride affected genes in mice liver. Environmental Toxicology and Pharmacology 26(2):150-161
Mitra,A.K.,Singh, N., Singh, A., Garg, V.K., Agarwal, A. Sharma, M., Rashmi Chaturvedi , R. and Rath,S.K. (2008): Association of polymorphisms in Base Excision Repair genes with the risk of Breast Cancer: a case-control study in north Indian women. Oncology Research 17 (3):127-135
Sanjeev Noel, Sharad Sharma, Rishi Shankar and Srikanta Kumar Rath (2008). Identification of differentially expressed genes following acute exposure to Bulaquine (CDRI 80/53) in mice liver Basic and Clinical Pharmacology and Toxicology, 103 (6), 522-529
The Indian Genome Variation Consortium (2008) Genetic Landscape of the People of India: a Canvas for Disease Gene Exploration. J Genetics, 87 (1), 3-20
Neetu Singh, Amit Kumar Mitra, Vivek Kumar Garg, Amit Agarwal, Mandira Sharma, Rashmi Chaturvedi and Srikanta Kumar Rath. (2007) Association of CYP1A1 polymorphisms with Breast Cancer in North Indian women. Oncology Research 16 (12):587-597
Sanjeev Noel, Sharad Sharma, Rishi Shanker and Srikanta Kumar Rath (2007): Primaquine-induced differential gene expression analysis in mice liver using DNA microarrays. Toxicology: 239 (1-2):96-107.
Sharma, R.,Muttil, P.,Yadav, A.B., Rath,S.K. Bajpai, V.K., Mani, U and Misra, A.
(2007): Uptake of inhalable microparticles affects defence responses of macrophages infected with Mycobacterium tuberculosis H37Ra. Journal of Antimicrobial Chemotherapy 59, 499–506
Singh, A., Chandra, S., Gupta, S.K., Chauhan, L.K.S., and Rath, S.K. (2007): Mutagenicity of Leachates from Industrial Solid Wastes using Salmonella Reverse Mutation Assay. Ecotoxicology and Environmental Safety 66:210-216
Noel, S. and Rath, S.K. (2006): Randomly amplified polymorphic DNA as a tool for genotoxicity: an assessment. Toxicology and Industrial Health, 22 (6):267-275
Noel, S., Kasinathan, M., and Rath, S.K. (2006): Evaluation of Apigenin using in vitro cytokinesis blocked micronucleus assay. Toxicology in Vitro, 20 (7), 1168-1172
The Indian Genome Variation database Consortium (2005): The Indian Genome Variation database (IGVdb): An overview, Human Genetics 118: 1-11
Rath, S.K. & Tandon S. (2004): Clinical relevance of CYP 2D6 Polymorphism. Drugs and Pharmaceuticals Current R& D Highlights 27 (3): 18-20
Singh, A., Mitra, A.K, Sharma, R.K. and Rath S.K. (2004): Pharmacogenomics- A new approach to Drug Development. Drugs and Pharmaceuticals current R& D Highlights 27 (3): 8-17
Singh, M.K., Rath, S.K., Kapoor, V.K. and Choudhury, G. (2002). Toxicological evaluation of bile specimen from gall bladder cancer. Indian Journal of Gastroenterology, 21 (Suppl 1): 50
Rath, S.K. (2002): Drug Research, the Genetic Perspective. Drugs and Pharmaceuticals current R& D Highlights 25 (4): 6-10
Rath, S.K., Sharma, S. and Srivastava, Sudhir (2001) Regulatory toxicology in Pharmaceuticals. C R I P S. 2(2):1-7
Rath, S.K., Singh, S.K. (1996): 1-4 (Chloro-2-Methylphenyl)-1H-indazole-3-Carboxylic acid-induced changes in the reproductive organs of the male mouse. Asian J Andrology (Supplement). P14
Rath, S.K., Singh, S.K. (1996): Effect of DL-6- (N-Pipecolinomethyl)-5- hydroxy indane maleate (PMHI) on fertility of male mice. Jl. Sci Res. 46: 9-13
Rath, S.K. (1996): Effects of Certain Antifertility Agents on the reproductive organs of the male laboratory mouse. Jl Sci Res. 46:183-186
Singh, S.K., Rath, S.K. (1990): Histologic Changes in the Mouse Testis after treatment with Gossypol Tetra acetic acid. Archives of Histology and Cytology 53 (4): 393-396