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| Dr.
SRIKANTA KUMAR RATH |
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Scientist E-I
Genotoxicity Laboratory
Toxicology Division
Central Drug Research Institute
Lucknow 226001
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| POST-DOCTORAL
RESEARCH |
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Post Doctoral
Research: CCMB, Hyderabad, 1995-1998 |
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| RESEARCH
GROUP MEMBERS- |
Presently Working |
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Shrawan Kumar Mishra, Senior Research
Fellow, ICMR
Bipin Chand Misra, Senior Research
Fellow, CSIR
Prabhat Singh, Junior Research Fellow,
DBT
Sarvendra Vikram Singh, Junior Research
Fellow, CSIR
Pratibha Mishra, Project Assistant,
ICMR
Pallavi Srivastava, Project Assistant,
CSIR
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Past Members |
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Ashok Singh, presently Post Doctoral
Research Scholar at Mayo Clinic, Scottsdale, Arizona,
US
Sanjeev Noel, presently Post Doctoral
Fellow at Johns Hopkins School of Public Health, Baltimore,
USA
Dr. Neetu Singh, Woman Scientist(
DST) C&T Unit, CDRI
Amit Kumar Mitra, Post Doctoral Fellow, University
of Minnesota, USA
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| NOTABLE
RECOGNITIONS |
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2007:
Raman Research Fellow
2007-08: Visiting Scientist,
Johns Hopkins Bloomberg School of Public
Health, Baltimore, MD, USA
2008 : Genomic Pioneer Award |
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| CURRENT
AREAS OF INTEREST |
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Genotoxicity
evaluation of new drug entities. |
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Development/Establishment
of new in vitro assay systems to evaluate genotoxic effects
of new candidate drugs and models for different diseases.
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Studying Single Nucleotide
Polymorphisms in drug metabolizing enzymes, DNA repair
genes and cancer related genes in Indian populations. |
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Global gene expression
studies following exposure to different toxicants using
microarrays and real time PCR |
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| SELECTED
PUBLICATIONS |
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Singh,N. Nigam, M., Ranjan,
V, Sharma,R.S., Balapure, A. and Rath, S.K. (2009):
Caspase mediated enhanced apoptotic action of Cyclophosphamide
and Resveratrol treated MCF-7 cells. Journal of
pharmacological sciences (accepted) |
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Brahma M.K., Dohare, P,
Varma, S., Rath, S.K., Garg, P., Biswal,
P.K., Dhar Chowdhury, P. and Ray, M. (2008):
The neuronal apoptotic death in global cerebral ischemia
in gerbil: important role for sodium channel modulator.
Journal of Neuroscience Research (accepted) |
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Singh A, Boldin-Adamsky
S, Thimmulappa RK, Rath SK, Ashush H,
Coulter J, Blackford A, Goodman SN, Bunz F, Watson WH,
Gabrielson E, Feinstein E, Biswal S. (2008)
RNAi-mediated silencing of nuclear factor erythroid-2-related
factor 2 gene expression in non-small cell lung cancer
inhibits tumor growth and increases efficacy of chemotherapy.
Cancer Research : 68 (19):7975-7984 |
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Noel,S. Sharma, S. and
Rath, S.K. (2008).Simultaneous
application of t-test and fold change criteria to identify
acetaminophen and carbon tetrachloride affected genes
in mice liver. Environmental Toxicology and Pharmacology
26(2):150-161 |
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Singh , S.K. and Rath,
S.K. (2008) Effect of Gossypol
Tetra-acetic Acid on the Reproductive Organs in Male Mice.
Recent Advances in Medicinal Plants, Studium
press LLC,Houston :167-184 |
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Mitra,A.K.,Singh, N.,
Singh, A., Garg, V.K., Agarwal, A. Sharma, M., Rashmi
Chaturvedi , R. and Rath,S.K. (2008):
Association of polymorphisms in Base Excision Repair genes
with the risk of Breast Cancer: a case-control study in
north Indian women. Oncology Research
17 (3):127-135 |
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Sanjeev Noel, Sharad Sharma
and Srikanta Kumar Rath (2008).Simultaneous
application of t-test and fold change criteria to identify
acetaminophen and carbon tetrachloride affected genes
in mice liver. Environmental Toxicology and Pharmacology
(accepted) |
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Shio Kumar Singh and Srikanta
Kumar Rath (2008) Effect of Gossypol Tetra-acetic
Acid on the Reproductive Organs in Male Mice. Recent
Advances in Medicinal Plants (accepted) |
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Amit Kumar Mitra, Neetu
Singh, Ashok Singh, Vivek Kumar Garg, Amit Agarwal, Mandira
Sharma, Rashmi Chaturvedi and Srikanta Kumar Rath.
(2008) Association of polymorphisms in Base Excision
Repair genes with the risk of Breast Cancer: a case-control
study in north Indian women. Oncology Research
(accepted) |
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Sanjeev Noel, Sharad Sharma,
Rishi Shankar and Srikanta Kumar Rath (2008).
Identification of differentially expressed genes following
acute exposure to Bulaquine (CDRI 80/53) in mice liver
Basic and Clinical Pharmacology and Toxicology
(accepted) |
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The Indian Genome Variation
Consortium (2008) Genetic Landscape of
the People of India: a Canvas for Disease Gene Exploration.
J Genetics (accepted) |
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Neetu Singh, Amit Kumar
Mitra, Vivek Kumar Garg, Amit Agarwal, Mandira Sharma,
Rashmi Chaturvedi and Srikanta Kumar Rath. (2007)
Association of CYP1A1 polymorphisms with Breast Cancer
in North Indian women. Oncology Research
16 (12):587-597 |
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Sanjeev Noel, Sharad Sharma,
Rishi Shanker and Srikanta Kumar Rath (2007):
Primaquine-induced differential gene expression analysis
in mice liver using DNA microarrays. Toxicology:
239 (1-2):96-107. |
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Sharma, R.,Muttil, P.,Yadav,
A.B., Rath,S.K. Bajpai, V.K., Mani, U
and Misra, A.
(2007): Uptake of inhalable microparticles
affects defence responses of macrophages infected with
Mycobacterium tuberculosis H37Ra. Journal of Antimicrobial
Chemotherapy 59, 499–506 |
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Singh, A., Chandra, S.,
Gupta, S.K., Chauhan, L.K.S., and Rath, S.K. (2007):
Mutagenicity of Leachates from Industrial Solid Wastes
using Salmonella Reverse Mutation Assay. Ecotoxicology
and Environmental Safety 66:210-216 |
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Noel, S. and Rath,
S.K. (2006): Randomly amplified polymorphic DNA
as a tool for genotoxicity: an assessment. Toxicology
and Industrial Health, 22 (6):267-275 |
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Noel, S., Kasinathan,
M., and Rath, S.K. (2006): Evaluation
of Apigenin using in vitro cytokinesis blocked micronucleus
assay. Toxicology in Vitro, 20 (7), 1168-1172 |
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The Indian Genome Variation
database Consortium (2005): The Indian
Genome Variation database (IGVdb): An overview, Human
Genetics 118: 1-11 |
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Rath, S.K.
& Tandon S. (2004): Clinical relevance
of CYP 2D6 Polymorphism. Drugs and Pharmaceuticals
Current R& D Highlights 27 (3): 18-20 |
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Singh, A., Mitra, A.K,
Sharma, R.K. and Rath S.K. (2004): Pharmacogenomics-
A new approach to Drug Development. Drugs and
Pharmaceuticals current R& D Highlights 27
(3): 8-17 |
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Singh, M.K., Rath,
S.K., Kapoor, V.K. and Choudhury, G. (2002).
Toxicological evaluation of bile specimen from gall bladder
cancer. Indian Journal of Gastroenterology,
21 (Suppl 1): 50 |
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Rath, S.K. (2002):
Drug Research, the Genetic Perspective. Drugs
and Pharmaceuticals current R& D Highlights 25 (4):
6-10 |
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Rath, S.K.,
Sharma, S. and Srivastava, Sudhir (2001)
Regulatory toxicology in Pharmaceuticals. C
R I P S. 2(2):1-7 |
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Rath, S.K.,
Singh, S.K. (1996): 1-4 (Chloro-2-Methylphenyl)-1H-indazole-3-Carboxylic
acid-induced changes in the reproductive organs of the
male mouse. Asian J Andrology (Supplement).
P14 |
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Rath,
S.K., Singh, S.K. (1996): Effect of DL-6-
(N-Pipecolinomethyl)-5- hydroxy indane maleate (PMHI)
on fertility of male mice. Jl. Sci Res.
46: 9-13 |
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Rath, S.K.
(1996): Effects of Certain Antifertility
Agents on the reproductive organs of the male laboratory
mouse. Jl Sci Res. 46:183-186 |
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Singh, S.K., Rath,
S.K. (1990): Histologic Changes in the Mouse
Testis after treatment with Gossypol Tetra acetic acid.
Archives of Histology and Cytology 53
(4): 393-396 |
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