|
| |
|
DR. SUDHIR KUMAR SINHA |
|
| |
 |
... |
Scientist F & Scientist in Charge
Drug Target Discovery & Development Division
Central Drug Research Institute
LUCKNOW
|
| |
|
|
| |
| AREA OF RESEARCH SPECIALIZATION |
| |
|
•
|
Biochemistry and immunology of mycobacterial infections.
|
|
| |
| ACADEMIC AWARDS/ HONOURS |
| |
|
• |
JALMA
Trust Fund Oration Award' (1995) of Indian Council of
Medical Research. |
|
• |
Acworth
Leprosy Hospital Research Society Award' (1985) of Indian
Association of Leprologists. |
• |
British Council
Fellowship (1982). |
|
| |
| PUBLICATIONS |
| |
|
•
|
Over
75 original papers in SCI Journals. |
|
| |
| PATENTS |
| |
|
|
|
| PRESENT AREA OF ACTIVITY |
| |
|
•
|
Tuberculosis therapeutics and High-throughput Screening
|
|
| |
| SELECTED
PUBLICATIONS |
| |
• |
AN Gaikwad,
Sudhir Sinha, 2008. Determinants of natural
immunity against tuberculosis in an endemic setting: factors
operating at the level of macrophage- Mycobacterium tuberculosis
interaction. Clinical and Experimental Immunology
151, 414-22. |
• |
S Ghosh , P Tiwari , S
Pandey, AK Misra, V Chaturvedi, A Gaikwad, S Bhatnagar,
Sudhir Sinha, 2008.
Synthesis and evaluation of antitubercular activity of
glycosyl thio- and sulfonyl acetamide derivatives. Bioorganic
and Medicinal Chemistry Letters 18:4002-5. |
• |
MK Parai, G Panda, V Chaturvedi,
YK Manju, Sudhir Sinha, 2008. Thiophene
containing triarylmethanes as antitubercular agents.
Bioorganic and Medicinal Chemistry Letters 18,
289-92. |
• |
V Chaturvedi, BK Girdhar,
U Sengupta, Sudhir Sinha, 2007. Semi-quantitative
detection of Mycobacterium leprae antigens in skin scrapings:
Suitability as a laboratory aid for field diagnosis of
leprosy. Transactions of Royal Society of Tropical
Medicine and Hygiene 101, 699-706. |
• |
SK Gupta, BS Sisodia,
Sudhir Sinha, K Hajela, S Naik, A K Shasany,
A Dube, 2007. Proteomic approach for
identification and characterization of novel immunostimulatory
proteins from soluble antigens of Leishmania donovani
promastigotes. Proteomics 7, 816–823. |
• |
M Saquib, MK Gupta, R
Sagar, YS Prabhakar, AK Shaw, R Kumar, PR Maulik, A Gaikwad,
Sudhir Sinha, AK Srivastava, V Chaturvedi,
R Srivastava, BS Srivastava, 2007. C-3
alkyl/arylalkyl1-2,3-dideoxy hex-2-enopyranosides as antitubercular
agents: synthesis, biological evaluation and QSAR study.
Journal of Medicinal Chemistry 50, 2942-50. |
• |
RP Tripathi, N Saxena,
VK Tiwari, SS Verma, V Chaturvedi, YK Manju YK, AK Srivastava,
A Gaikwad, Sudhir Sinha, 2006. Synthesis
and antitubercular activity of substituted phenylmethyl-
and pyridylmethyl amines. Bioorganic and Medicinal
Chemistry 14, 8186-96. |
• |
Sudhir Sinha,
K Kosalai, S Arora, A Namane, P Sharma, AN Gaikwad, P
Brodin, ST Cole, 2005. Immunogenic membrane-associated
proteins of Mycobacterium tuberculosis revealed by proteomics.
Microbiology 151, 2411-9. |
• |
Sudhir Sinha,
S Kannan, B Nagaraju, U Sengupta, MD Gupte, 2004.
Utility of serodiagnostic tests for leprosy: a study in
an endemic population in South India. Leprosy
Review 75, 266-73. |
• |
Sudhir Sinha,
S Arora, K Kosalai, A Namane, A S Pym, ST Cole,
2002. Proteome analysis of the plasma membrane
of Mycobacterium tuberculosis. Comparative
and Functional Genomics 3, 470-483. |
• |
J Mehrotra, A Mittal,
AK Rastogi, AK Jaiswal, NK Bhandari, Sudhir Sinha,
1999. Antigenic definition of plasma membrane
proteins of BCG: Predominant activation of human T cells
by low molecular weight integral proteins. Scandinavian
Journal of Immunology 50, 411-9. |
• |
RJ Wilkinson, KA Wilkinson,
S Jurcevic, A Hills, Sudhir Sinha, U
Sengupta, DNJ Lockwood, K Katoch, D Altman, J Ivanyi,
1999. Specificity and function of immunogenic
peptides from the 35- kilodalton protein of Mycobacterium
leprae. Infection and Immunity 67, 1501-4. |
• |
J Mehrotra, A Mittal,
MS Dhindsa, Sudhir Sinha, 1997. Fractionation
of mycobacterial integral membrane proteins by continuous
elution SDS-PAGE reveals the immunodominance of low molecular
weight subunits for human T cells. Clinical and
Experimental Immunology 109, 446-50. |
• |
D Bisht, J Mehrotra, MS
Dhindsa, NB Singh, Sudhir Sinha, 1996.
A Major T cell inducing cytosolic 23 kDa protein antigen
of the vaccine candidate Mycobacterium habana is superoxide
dismutase. Microbiology 142, 1375-83. |
• |
J Mehrotra, D Bisht, VD
Tiwari, Sudhir Sinha, 1995. Serological
distinction of integral plasma membrane proteins as a
class of mycobacterial antigens and their relevance for
human T cell activation. Clinical and Experimental
Immunology 102, 626-34. |
| |
|
|
|
|
| |
|